ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 26/240 152/7206 3.38262368778e-12 ko04080 Neuroactive ligand-receptor interaction 44/240 423/7206 6.02469455181e-12 ko04020 Calcium signaling pathway 30/240 265/7206 2.79270609264e-09 ko05031 Amphetamine addiction 15/240 91/7206 2.54969653203e-07 ko04713 Circadian entrainment 18/240 136/7206 4.91925463399e-07 ko04072 Phospholipase D signaling pathway 22/240 197/7206 5.30865032267e-07 ko05030 Cocaine addiction 13/240 73/7206 6.53883819972e-07 ko05033 Nicotine addiction 11/240 56/7206 1.75985268223e-06 ko04728 Dopaminergic synapse 20/240 185/7206 2.97427229714e-06 ko04720 Long-term potentiation 14/240 99/7206 4.31282753486e-06 ko05231 Choline metabolism in cancer 16/240 134/7206 8.46631560331e-06 ko04024 cAMP signaling pathway 24/240 279/7206 1.67654317811e-05 ko04070 Phosphatidylinositol signaling system 14/240 112/7206 1.8538804464e-05 ko05032 Morphine addiction 13/240 110/7206 6.71776047322e-05 ko04360 Axon guidance 19/240 233/7206 0.000263741463374 ko04725 Cholinergic synapse 15/240 160/7206 0.000268070291244 ko04911 Insulin secretion 12/240 117/7206 0.000488710175953 ko04742 Taste transduction 8/240 61/7206 0.00086205012639 ko04727 GABAergic synapse 11/240 110/7206 0.00103297858057 ko04730 Long-term depression 9/240 78/7206 0.00106624299034 ko04740 Olfactory transduction 9/240 80/7206 0.00127989649061 ko04261 Adrenergic signaling in cardiomyocytes 16/240 205/7206 0.00128769853857 ko00564 Glycerophospholipid metabolism 10/240 99/7206 0.00160825838968 ko05203 Viral carcinogenesis 1/240 277/7206 0.00164523465756 ko04723 Retrograde endocannabinoid signaling 14/240 175/7206 0.00203334764994 ko04912 GnRH signaling pathway 11/240 122/7206 0.00239593735996 ko04666 Fc gamma R-mediated phagocytosis 11/240 122/7206 0.00239593735996 ko04925 Aldosterone synthesis and secretion 10/240 105/7206 0.0025027572218 ko00562 Inositol phosphate metabolism 9/240 89/7206 0.00270759499298 ko04022 cGMP-PKG signaling pathway 16/240 216/7206 0.00280675978794 ko04144 Endocytosis 22/240 342/7206 0.00284549114676 ko04540 Gap junction 11/240 128/7206 0.0034890547473 ko04923 Regulation of lipolysis in adipocytes 8/240 77/7206 0.00390310221984 ko04915 Estrogen signaling pathway 11/240 131/7206 0.00416888348912 ko04921 Oxytocin signaling pathway 15/240 209/7206 0.00482811469911 ko04726 Serotonergic synapse 11/240 137/7206 0.00584400958603 ko04211 Longevity regulating pathway 10/240 123/7206 0.0077388011786 ko00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin 4/240 26/7206 0.0100738696965 ko04012 ErbB signaling pathway 9/240 109/7206 0.0102423195739 ko05014 Amyotrophic lateral sclerosis (ALS) 7/240 74/7206 0.0112457726924 ko05414 Dilated cardiomyopathy 9/240 112/7206 0.0121177290333 ko04970 Salivary secretion 8/240 95/7206 0.0135442150624 ko00512 Mucin type O-glycan biosynthesis 4/240 29/7206 0.0148082097478 ko04971 Gastric acid secretion 8/240 98/7206 0.0161138223539 ko05213 Endometrial cancer 6/240 62/7206 0.0166209958028 ko04371 Apelin signaling pathway 12/240 177/7206 0.0172031848382 ko00561 Glycerolipid metabolism 6/240 63/7206 0.0178755196489 ko04213 Longevity regulating pathway - multiple species 7/240 86/7206 0.0240567038071 ko04062 Chemokine signaling pathway 13/240 201/7206 0.0246528020276 ko04011 MAPK signaling pathway - yeast 5/240 53/7206 0.030792686803 ko04972 Pancreatic secretion 8/240 111/7206 0.0313911335159 ko04139 Mitophagy - yeast 4/240 37/7206 0.0335209812937 ko04015 Rap1 signaling pathway 16/240 278/7206 0.0378569165729 ko04014 Ras signaling pathway 16/240 279/7206 0.0381752003702 ko05034 Alcoholism 14/240 238/7206 0.0398241229733 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 6/240 79/7206 0.0473684633674 ko05214 Glioma 6/240 79/7206 0.0473684633674 ko00515 Mannose type O-glycan biosynthesis 3/240 25/7206 0.0489160118223