ko pathway ratio_in_study ratio_in_pop p_value ko04070 Phosphatidylinositol signaling system 21/353 112/7206 8.17048388532e-08 ko04724 Glutamatergic synapse 22/353 152/7206 4.09637292181e-06 ko00562 Inositol phosphate metabolism 15/353 89/7206 2.31216603412e-05 ko04911 Insulin secretion 16/353 117/7206 0.00016973093942 ko04725 Cholinergic synapse 19/353 160/7206 0.000285382970896 ko04726 Serotonergic synapse 17/353 137/7206 0.000352288224201 ko04745 Phototransduction - fly 8/353 38/7206 0.000410869368495 ko05230 Central carbon metabolism in cancer 12/353 81/7206 0.000525301115611 ko04728 Dopaminergic synapse 20/353 185/7206 0.000767364357625 ko04727 GABAergic synapse 14/353 110/7206 0.000896153584216 ko05032 Morphine addiction 14/353 110/7206 0.000896153584216 ko04713 Circadian entrainment 16/353 136/7206 0.000943293975331 ko04925 Aldosterone synthesis and secretion 13/353 105/7206 0.00175061168996 ko04020 Calcium signaling pathway 25/353 265/7206 0.00192602458753 ko04080 Neuroactive ligand-receptor interaction 35/353 423/7206 0.00227883223167 ko04919 Thyroid hormone signaling pathway 16/353 143/7206 0.00232087421673 ko04971 Gastric acid secretion 12/353 98/7206 0.00285779613642 ko04720 Long-term potentiation 12/353 99/7206 0.00311254165293 ko04960 Aldosterone-regulated sodium reabsorption 7/353 41/7206 0.003389071092 ko05031 Amphetamine addiction 11/353 91/7206 0.00466664616282 ko04970 Salivary secretion 11/353 95/7206 0.00647111451437 ko04261 Adrenergic signaling in cardiomyocytes 19/353 205/7206 0.00746789943309 ko04921 Oxytocin signaling pathway 19/353 209/7206 0.00838366453873 ko04918 Thyroid hormone synthesis 10/353 86/7206 0.00897085849789 ko03040 Spliceosome 1/353 145/7206 0.010260528557 ko04072 Phospholipase D signaling pathway 18/353 197/7206 0.0106238043199 ko05110 Vibrio cholerae infection 8/353 63/7206 0.0112332205282 ko04972 Pancreatic secretion 12/353 111/7206 0.0114854923659 ko04964 Proximal tubule bicarbonate reclamation 5/353 29/7206 0.0123224926716 ko00471 D-Glutamine and D-glutamate metabolism 2/353 4/7206 0.0134436814927 ko04022 cGMP-PKG signaling pathway 19/353 216/7206 0.0146963045608 ko04710 Circadian rhythm 6/353 43/7206 0.0174134715514 ko04750 Inflammatory mediator regulation of TRP channels 12/353 122/7206 0.0180950378174 ko05033 Nicotine addiction 7/353 56/7206 0.0187031426915 ko03010 Ribosome 1/353 129/7206 0.0215195974954 ko05231 Choline metabolism in cancer 13/353 134/7206 0.0228786637869 ko04711 Circadian rhythm - fly 3/353 13/7206 0.0231040308771 ko04024 cAMP signaling pathway 22/353 279/7206 0.023374725276 ko00010 Glycolysis / Gluconeogenesis 8/353 74/7206 0.0275441239749 ko05014 Amyotrophic lateral sclerosis (ALS) 8/353 74/7206 0.0275441239749 ko05010 Alzheimer's disease 17/353 202/7206 0.0293250610526 ko04723 Retrograde endocannabinoid signaling 15/353 175/7206 0.0315147121301 ko04922 Glucagon signaling pathway 12/353 128/7206 0.0343297160476 ko04662 B cell receptor signaling pathway 9/353 88/7206 0.0393922702608 ko04014 Ras signaling pathway 21/353 279/7206 0.0464174057785 ko00061 Fatty acid biosynthesis 3/353 17/7206 0.0475608876051 ko00140 Steroid hormone biosynthesis 5/353 41/7206 0.0483688058184 ko02025 Biofilm formation - Pseudomonas aeruginosa 1/353 1/7206 0.0489869553152