ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko03040	Spliceosome	96/964	145/7206	4.56323318818e-50
ko04110	Cell cycle	70/964	145/7206	9.95257824187e-25
ko04080	Neuroactive ligand-receptor interaction	3/964	423/7206	5.09927390816e-23
ko03030	DNA replication	30/964	38/7206	6.94009329335e-20
ko04111	Cell cycle - yeast	48/964	90/7206	1.26230078931e-19
ko03008	Ribosome biogenesis in eukaryotes	43/964	79/7206	3.75317695335e-18
ko03013	RNA transport	66/964	166/7206	9.02218529377e-18
ko04113	Meiosis - yeast	35/964	70/7206	1.55310534666e-13
ko04020	Calcium signaling pathway	3/964	265/7206	2.78431094215e-13
ko03410	Base excision repair	24/964	38/7206	1.24194939034e-12
ko04144	Endocytosis	10/964	342/7206	1.75947965083e-11
ko03460	Fanconi anemia pathway	26/964	51/7206	1.24158150332e-10
ko03015	mRNA surveillance pathway	37/964	93/7206	1.62370149731e-10
ko03430	Mismatch repair	16/964	22/7206	3.18354266526e-10
ko05217	Basal cell carcinoma	30/964	68/7206	4.48478592747e-10
ko04724	Glutamatergic synapse	1/964	152/7206	1.00779576644e-08
ko00240	Pyrimidine metabolism	38/964	110/7206	1.02210406891e-08
ko03420	Nucleotide excision repair	22/964	46/7206	1.55800968305e-08
ko04932	Non-alcoholic fatty liver disease (NAFLD)	3/964	182/7206	2.69903483921e-08
ko05322	Systemic lupus erythematosus	46/964	151/7206	3.44061170528e-08
ko04921	Oxytocin signaling pathway	5/964	209/7206	4.09654000192e-08
ko04723	Retrograde endocannabinoid signaling	3/964	175/7206	5.86391003033e-08
ko04726	Serotonergic synapse	1/964	137/7206	8.19042017263e-08
ko03018	RNA degradation	30/964	84/7206	1.58417158701e-07
ko03440	Homologous recombination	19/964	41/7206	2.8279023267e-07
ko04550	Signaling pathways regulating pluripotency of stem cells	47/964	165/7206	3.11442034707e-07
ko04022	cGMP-PKG signaling pathway	7/964	216/7206	4.32911256126e-07
ko04072	Phospholipase D signaling pathway	6/964	197/7206	1.10057777199e-06
ko04725	Cholinergic synapse	4/964	160/7206	2.87934182491e-06
ko04621	NOD-like receptor signaling pathway	4/964	157/7206	4.20761009364e-06
ko04024	cAMP signaling pathway	14/964	279/7206	5.64972238592e-06
ko04060	Cytokine-cytokine receptor interaction	7/964	191/7206	7.51721136477e-06
ko05166	HTLV-I infection	66/964	292/7206	9.75039131109e-06
ko04310	Wnt signaling pathway	46/964	181/7206	1.12739293846e-05
ko04062	Chemokine signaling pathway	8/964	201/7206	1.20922632098e-05
ko04971	Gastric acid secretion	1/964	98/7206	1.78301095279e-05
ko04915	Estrogen signaling pathway	3/964	131/7206	2.169183114e-05
ko04970	Salivary secretion	1/964	95/7206	2.68558195135e-05
ko05202	Transcriptional misregulation in cancer	46/964	188/7206	2.93869086348e-05
ko04727	GABAergic synapse	2/964	110/7206	3.05934292163e-05
ko05032	Morphine addiction	2/964	110/7206	3.05934292163e-05
ko04270	Vascular smooth muscle contraction	5/964	154/7206	3.39669221799e-05
ko04713	Circadian entrainment	4/964	136/7206	5.78630967971e-05
ko04390	Hippo signaling pathway	45/964	188/7206	7.38803079628e-05
ko04911	Insulin secretion	3/964	117/7206	9.33436203314e-05
ko03022	Basal transcription factors	16/964	44/7206	9.85591914828e-05
ko03010	Ribosome	4/964	129/7206	0.000117634506151
ko04371	Apelin signaling pathway	8/964	177/7206	0.000123727400886
ko03020	RNA polymerase	12/964	29/7206	0.000177979946428
ko04650	Natural killer cell mediated cytotoxicity	2/964	97/7206	0.000222204656219
ko04912	GnRH signaling pathway	4/964	122/7206	0.000240368417039
ko04923	Regulation of lipolysis in adipocytes	1/964	77/7206	0.000308433382732
ko04730	Long-term depression	1/964	78/7206	0.000312371250981
ko04925	Aldosterone synthesis and secretion	3/964	105/7206	0.000416758553299
ko04330	Notch signaling pathway	19/964	62/7206	0.00044001031903
ko04920	Adipocytokine signaling pathway	2/964	89/7206	0.000463443973076
ko04141	Protein processing in endoplasmic reticulum	10/964	184/7206	0.000606034542529
ko04611	Platelet activation	8/964	163/7206	0.000635204319362
ko04662	B cell receptor signaling pathway	2/964	88/7206	0.000709143470837
ko04950	Maturity onset diabetes of the young	11/964	29/7206	0.000802521398236
ko05034	Alcoholism	50/964	238/7206	0.000917392946206
ko05224	Breast cancer	39/964	174/7206	0.000958665133843
ko04972	Pancreatic secretion	4/964	111/7206	0.00101905429331
ko03320	PPAR signaling pathway	1/964	69/7206	0.00104780082642
ko04014	Ras signaling pathway	20/964	279/7206	0.00117448689785
ko04728	Dopaminergic synapse	11/964	185/7206	0.00141503847905
ko04976	Bile secretion	2/964	80/7206	0.00145473428546
ko04740	Olfactory transduction	2/964	80/7206	0.00145473428546
ko04138	Autophagy - yeast	2/964	81/7206	0.00147431896782
ko04010	MAPK signaling pathway	25/964	321/7206	0.00183476329895
ko04931	Insulin resistance	7/964	137/7206	0.00219248822471
ko04139	Mitophagy - yeast	12/964	37/7206	0.00228510766111
ko00561	Glycerolipid metabolism	1/964	63/7206	0.00233624793147
ko00230	Purine metabolism	41/964	194/7206	0.00255012990875
ko04070	Phosphatidylinositol signaling system	5/964	112/7206	0.00297863391185
ko04660	T cell receptor signaling pathway	6/964	124/7206	0.00306173817355
ko05152	Tuberculosis	12/964	187/7206	0.00310616036862
ko05140	Leishmaniasis	2/964	75/7206	0.00314396669078
ko04340	Hedgehog signaling pathway	16/964	58/7206	0.00329749161872
ko04961	Endocrine and other factor-regulated calcium reabsorption	1/964	59/7206	0.00342379713352
ko04261	Adrenergic signaling in cardiomyocytes	14/964	205/7206	0.00344653385011
ko01212	Fatty acid metabolism	1/964	60/7206	0.00348264281779
ko04924	Renin secretion	3/964	86/7206	0.00365026563546
ko05133	Pertussis	3/964	87/7206	0.00372898863553
ko05203	Viral carcinogenesis	54/964	277/7206	0.00379630564376
ko04260	Cardiac muscle contraction	4/964	98/7206	0.004014558105
ko05142	Chagas disease (American trypanosomiasis)	7/964	130/7206	0.00408182345675
ko04514	Cell adhesion molecules (CAMs)	7/964	130/7206	0.00408182345675
ko04810	Regulation of actin cytoskeleton	20/964	264/7206	0.00408880171398
ko00564	Glycerophospholipid metabolism	4/964	99/7206	0.0041243526502
ko05146	Amoebiasis	4/964	99/7206	0.0041243526502
ko04630	Jak-STAT signaling pathway	7/964	132/7206	0.00413182088419
ko04668	TNF signaling pathway	6/964	120/7206	0.00416020999426
ko00514	Other types of O-glycan biosynthesis	10/964	30/7206	0.00418418713826
ko05030	Cocaine addiction	2/964	73/7206	0.00474980737481
ko01200	Carbon metabolism	7/964	128/7206	0.00555307090518
ko04540	Gap junction	7/964	128/7206	0.00555307090518
ko04659	Th17 cell differentiation	5/964	106/7206	0.00575809082159
ko04114	Oocyte meiosis	30/964	139/7206	0.00763527987165
ko05145	Toxoplasmosis	7/964	126/7206	0.00764559272524
ko00280	Valine, leucine and isoleucine degradation	1/964	54/7206	0.00770990337434
ko05031	Amphetamine addiction	4/964	91/7206	0.00779638787957
ko05168	Herpes simplex infection	37/964	182/7206	0.00782719168644
ko04712	Circadian rhythm - plant	4/964	7/7206	0.00796343399686
ko00310	Lysine degradation	18/964	73/7206	0.00847164271044
ko04640	Hematopoietic cell lineage	2/964	64/7206	0.00941206030966
ko04380	Osteoclast differentiation	8/964	134/7206	0.00972753151376
ko05231	Choline metabolism in cancer	8/964	134/7206	0.00972753151376
ko04071	Sphingolipid signaling pathway	11/964	162/7206	0.00996558602609
ko04750	Inflammatory mediator regulation of TRP channels	7/964	122/7206	0.0101734486707
ko04720	Long-term potentiation	5/964	99/7206	0.0108528487968
ko04142	Lysosome	10/964	151/7206	0.0108669436275
ko04670	Leukocyte transendothelial migration	10/964	151/7206	0.0108669436275
ko05414	Dilated cardiomyopathy	6/964	112/7206	0.0108879079462
ko04620	Toll-like receptor signaling pathway	5/964	100/7206	0.0110018742618
ko05160	Hepatitis C	10/964	153/7206	0.0110708229855
ko04146	Peroxisome	4/964	89/7206	0.0110895960046
ko00670	One carbon pool by folate	7/964	20/7206	0.0119483716437
ko04910	Insulin signaling pathway	12/964	172/7206	0.0120317928306
ko04350	TGF-beta signaling pathway	23/964	103/7206	0.0122192138799
ko04530	Tight junction	18/964	228/7206	0.0130127326515
ko04722	Neurotrophin signaling pathway	11/964	160/7206	0.0130869171251
ko04974	Protein digestion and absorption	5/964	96/7206	0.0148995168483
ko05222	Small cell lung cancer	20/964	89/7206	0.0175361846519
ko04510	Focal adhesion	20/964	240/7206	0.0201177937058
ko05120	Epithelial cell signaling in Helicobacter pylori infection	5/964	92/7206	0.0202425545973
ko04137	Mitophagy - animal	4/964	82/7206	0.0210221782852
ko04151	PI3K-Akt signaling pathway	37/964	390/7206	0.0214406124317
ko04120	Ubiquitin mediated proteolysis	28/964	138/7206	0.0222175446504
ko04066	HIF-1 signaling pathway	8/964	123/7206	0.0223474915678
ko05144	Malaria	1/964	45/7206	0.0251122022326
ko00071	Fatty acid degradation	1/964	45/7206	0.0251122022326
ko04218	Cellular senescence	34/964	177/7206	0.025158744592
ko05410	Hypertrophic cardiomyopathy (HCM)	6/964	100/7206	0.0259340407841
ko00562	Inositol phosphate metabolism	5/964	89/7206	0.0275306696967
ko04015	Rap1 signaling pathway	25/964	278/7206	0.0305275503213
ko04012	ErbB signaling pathway	7/964	109/7206	0.0322569828219
ko04064	NF-kappa B signaling pathway	6/964	96/7206	0.0347151108252
ko04922	Glucagon signaling pathway	9/964	128/7206	0.0349800800513
ko05132	Salmonella infection	6/964	98/7206	0.035048903982
ko04960	Aldosterone-regulated sodium reabsorption	1/964	41/7206	0.036250622242
ko00051	Fructose and mannose metabolism	1/964	42/7206	0.0370879732902
ko04213	Longevity regulating pathway - multiple species	5/964	86/7206	0.0372962681217
ko05134	Legionellosis	4/964	74/7206	0.0392950555007
ko04933	AGE-RAGE signaling pathway in diabetic complications	10/964	135/7206	0.0403886498058
ko05110	Vibrio cholerae infection	3/964	63/7206	0.0404507639009
ko04913	Ovarian steroidogenesis	3/964	63/7206	0.0404507639009
ko00600	Sphingolipid metabolism	3/964	63/7206	0.0404507639009
ko04152	AMPK signaling pathway	13/964	161/7206	0.0461064013884