ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 38/479 152/7206 3.67730051755e-13 ko04080 Neuroactive ligand-receptor interaction 70/479 423/7206 3.69621388548e-13 ko04713 Circadian entrainment 35/479 136/7206 1.3056976914e-12 ko05033 Nicotine addiction 21/479 56/7206 1.86296229808e-11 ko04911 Insulin secretion 29/479 117/7206 3.12014614836e-10 ko04721 Synaptic vesicle cycle 23/479 80/7206 9.62180088554e-10 ko04728 Dopaminergic synapse 36/479 185/7206 3.12511062967e-09 ko04727 GABAergic synapse 26/479 110/7206 7.82438995872e-09 ko05032 Morphine addiction 26/479 110/7206 7.82438995872e-09 ko04723 Retrograde endocannabinoid signaling 34/479 175/7206 9.0883274874e-09 ko04725 Cholinergic synapse 31/479 160/7206 4.48299045623e-08 ko04024 cAMP signaling pathway 43/479 279/7206 2.00601606353e-07 ko04514 Cell adhesion molecules (CAMs) 26/479 130/7206 2.91942624464e-07 ko04020 Calcium signaling pathway 40/479 265/7206 8.26949628888e-07 ko04744 Phototransduction 12/479 36/7206 1.86588589817e-06 ko04726 Serotonergic synapse 25/479 137/7206 2.93631320603e-06 ko04925 Aldosterone synthesis and secretion 20/479 105/7206 1.49692722594e-05 ko04720 Long-term potentiation 19/479 99/7206 2.18521297179e-05 ko04745 Phototransduction - fly 11/479 38/7206 2.31759752372e-05 ko05031 Amphetamine addiction 18/479 91/7206 2.34020742999e-05 ko04710 Circadian rhythm 11/479 43/7206 8.17492994533e-05 ko04261 Adrenergic signaling in cardiomyocytes 29/479 205/7206 8.93814048473e-05 ko04970 Salivary secretion 17/479 95/7206 0.000146382300103 ko04921 Oxytocin signaling pathway 29/479 209/7206 0.00017428491695 ko04971 Gastric acid secretion 16/479 98/7206 0.000665348234139 ko05030 Cocaine addiction 13/479 73/7206 0.00091106113493 ko04360 Axon guidance 29/479 233/7206 0.00110507280095 ko05164 Influenza A 2/479 167/7206 0.00141093799356 ko00604 Glycosphingolipid biosynthesis - ganglio series 5/479 14/7206 0.00153854614603 ko04060 Cytokine-cytokine receptor interaction 3/479 191/7206 0.00172377596492 ko03010 Ribosome 1/479 129/7206 0.00214974067015 ko05203 Viral carcinogenesis 7/479 277/7206 0.00289127148274 ko04022 cGMP-PKG signaling pathway 26/479 216/7206 0.00313092502224 ko05014 Amyotrophic lateral sclerosis (ALS) 12/479 74/7206 0.00323501853999 ko04070 Phosphatidylinositol signaling system 16/479 112/7206 0.00324902936086 ko05166 HTLV-I infection 8/479 292/7206 0.00375835615462 ko05162 Measles 1/479 120/7206 0.0046644006275 ko04730 Long-term depression 12/479 78/7206 0.00503096945655 ko03013 RNA transport 3/479 166/7206 0.00673523942725 ko04072 Phospholipase D signaling pathway 23/479 197/7206 0.00816378461823 ko04711 Circadian rhythm - fly 4/479 13/7206 0.00850915549741 ko04120 Ubiquitin mediated proteolysis 2/479 138/7206 0.00853446016702 ko04930 Type II diabetes mellitus 9/479 54/7206 0.0085371548353 ko04750 Inflammatory mediator regulation of TRP channels 16/479 122/7206 0.00870056268863 ko04972 Pancreatic secretion 15/479 111/7206 0.0105109617917 ko04010 MAPK signaling pathway 33/479 321/7206 0.0112219226255 ko04630 Jak-STAT signaling pathway 2/479 132/7206 0.0121303718501 ko05161 Hepatitis B 4/479 173/7206 0.0189400763453 ko04740 Olfactory transduction 11/479 80/7206 0.0200687697042 ko05205 Proteoglycans in cancer 9/479 271/7206 0.0243047485532 ko04966 Collecting duct acid secretion 5/479 26/7206 0.0261297872817 ko04014 Ras signaling pathway 28/479 279/7206 0.0266315848945 ko04626 Plant-pathogen interaction 4/479 18/7206 0.0279721428593 ko04924 Renin secretion 11/479 86/7206 0.0289802660224 ko04146 Peroxisome 1/479 89/7206 0.0298728300699 ko05168 Herpes simplex infection 5/479 182/7206 0.0331182803604 ko00240 Pyrimidine metabolism 2/479 110/7206 0.0334271098783 ko05110 Vibrio cholerae infection 9/479 63/7206 0.0353160018241 ko05010 Alzheimer's disease 21/479 202/7206 0.0429085124663 ko01200 Carbon metabolism 3/479 128/7206 0.0474553361055 ko00562 Inositol phosphate metabolism 11/479 89/7206 0.0486498198255