ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 43/335 191/7206 9.32943199392e-19 ko05164 Influenza A 35/335 167/7206 2.05112473638e-14 ko04380 Osteoclast differentiation 30/335 134/7206 2.64801874266e-13 ko05168 Herpes simplex infection 35/335 182/7206 3.10829402082e-13 ko05340 Primary immunodeficiency 15/335 30/7206 6.18876021755e-13 ko04217 Necroptosis 34/335 178/7206 8.50844027333e-13 ko05140 Leishmaniasis 22/335 75/7206 1.32277924895e-12 ko04621 NOD-like receptor signaling pathway 31/335 157/7206 3.6870284731e-12 ko05162 Measles 27/335 120/7206 3.84488617941e-12 ko05330 Allograft rejection 13/335 24/7206 5.92111095646e-12 ko04650 Natural killer cell mediated cytotoxicity 24/335 97/7206 7.20640457532e-12 ko05321 Inflammatory bowel disease (IBD) 18/335 56/7206 2.76867639653e-11 ko05145 Toxoplasmosis 26/335 126/7206 7.8219309446e-11 ko05152 Tuberculosis 32/335 187/7206 8.75066902217e-11 ko04064 NF-kappa B signaling pathway 22/335 96/7206 2.78861952054e-10 ko04612 Antigen processing and presentation 19/335 77/7206 1.24327091217e-09 ko05332 Graft-versus-host disease 10/335 18/7206 1.29669870312e-09 ko04659 Th17 cell differentiation 22/335 106/7206 2.09920256614e-09 ko05320 Autoimmune thyroid disease 12/335 29/7206 2.131085303e-09 ko05150 Staphylococcus aureus infection 13/335 36/7206 3.29620874544e-09 ko04620 Toll-like receptor signaling pathway 20/335 100/7206 2.25661535799e-08 ko04630 Jak-STAT signaling pathway 23/335 132/7206 3.07162449121e-08 ko05167 Kaposi's sarcoma-associated herpesvirus infection 28/335 191/7206 4.80698050277e-08 ko04622 RIG-I-like receptor signaling pathway 15/335 62/7206 9.51626324045e-08 ko04660 T cell receptor signaling pathway 21/335 124/7206 2.0598522225e-07 ko04658 Th1 and Th2 cell differentiation 18/335 96/7206 3.23740385784e-07 ko05310 Asthma 8/335 17/7206 3.3795711327e-07 ko04940 Type I diabetes mellitus 10/335 32/7206 1.06524654779e-06 ko05144 Malaria 11/335 45/7206 4.55181981575e-06 ko04672 Intestinal immune network for IgA production 10/335 37/7206 4.67021583107e-06 ko04640 Hematopoietic cell lineage 13/335 64/7206 5.73772287141e-06 ko04062 Chemokine signaling pathway 25/335 201/7206 5.75192219749e-06 ko05133 Pertussis 15/335 87/7206 9.31791767047e-06 ko04610 Complement and coagulation cascades 14/335 79/7206 1.33665945819e-05 ko05161 Hepatitis B 22/335 173/7206 1.48552727262e-05 ko05160 Hepatitis C 20/335 153/7206 2.43163817735e-05 ko05142 Chagas disease (American trypanosomiasis) 18/335 130/7206 2.8451890779e-05 ko04662 B cell receptor signaling pathway 14/335 88/7206 4.72483585719e-05 ko04145 Phagosome 20/335 162/7206 5.60322007746e-05 ko04623 Cytosolic DNA-sensing pathway 9/335 41/7206 8.51896330877e-05 ko03050 Proteasome 10/335 54/7206 0.000158417199213 ko05323 Rheumatoid arthritis 13/335 89/7206 0.000214473690998 ko05034 Alcoholism 1/335 238/7206 0.000232518434358 ko00590 Arachidonic acid metabolism 9/335 52/7206 0.000569533555374 ko04210 Apoptosis 19/335 180/7206 0.000831300897619 ko04668 TNF signaling pathway 14/335 120/7206 0.00127924933175 ko00120 Primary bile acid biosynthesis 5/335 20/7206 0.0018324778365 ko05169 Epstein-Barr virus infection 20/335 206/7206 0.00191973856561 ko05146 Amoebiasis 12/335 99/7206 0.00201711384578 ko04728 Dopaminergic synapse 1/335 185/7206 0.00229245356316 ko04664 Fc epsilon RI signaling pathway 10/335 77/7206 0.00281456590208 ko05143 African trypanosomiasis 6/335 32/7206 0.00313361427912 ko04310 Wnt signaling pathway 1/335 181/7206 0.00343804095163 ko05416 Viral myocarditis 8/335 55/7206 0.00360759218111 ko04666 Fc gamma R-mediated phagocytosis 13/335 122/7206 0.00421753984291 ko04137 Mitophagy - animal 10/335 82/7206 0.00447215468802 ko04723 Retrograde endocannabinoid signaling 1/335 175/7206 0.00519480301883 ko04514 Cell adhesion molecules (CAMs) 13/335 130/7206 0.00914207667482 ko04360 Axon guidance 3/335 233/7206 0.0101494972093 ko04611 Platelet activation 15/335 163/7206 0.0122061430456 ko04390 Hippo signaling pathway 2/335 188/7206 0.0126327701354 ko03040 Spliceosome 1/335 145/7206 0.0150141892013 ko04670 Leukocyte transendothelial migration 14/335 151/7206 0.0162920439284 ko04657 IL-17 signaling pathway 9/335 87/7206 0.0191880131799 ko05166 HTLV-I infection 22/335 292/7206 0.0225285322682 ko05132 Salmonella infection 10/335 98/7206 0.0243683562801 ko04020 Calcium signaling pathway 5/335 265/7206 0.025030673892 ko00511 Other glycan degradation 4/335 26/7206 0.0305275465015 ko04922 Glucagon signaling pathway 1/335 128/7206 0.0313269830087 ko03010 Ribosome 1/335 129/7206 0.0315944101026 ko04530 Tight junction 4/335 228/7206 0.0356489592303 ko00980 Metabolism of xenobiotics by cytochrome P450 5/335 40/7206 0.0364978838905 ko04080 Neuroactive ligand-receptor interaction 11/335 423/7206 0.0419072550624 ko00051 Fructose and mannose metabolism 5/335 42/7206 0.0437962754978 ko04724 Glutamatergic synapse 2/335 152/7206 0.0489227773727