ko pathway ratio_in_study ratio_in_pop p_value ko05164 Influenza A 31/388 167/7206 8.39237899771e-10 ko04650 Natural killer cell mediated cytotoxicity 23/388 97/7206 9.71009042695e-10 ko05340 Primary immunodeficiency 12/388 30/7206 1.79501242537e-08 ko04060 Cytokine-cytokine receptor interaction 30/388 191/7206 8.78067021627e-08 ko04621 NOD-like receptor signaling pathway 26/388 157/7206 2.24841272821e-07 ko04380 Osteoclast differentiation 23/388 134/7206 5.9279673822e-07 ko05321 Inflammatory bowel disease (IBD) 14/388 56/7206 9.9283413209e-07 ko05162 Measles 21/388 120/7206 1.33119414716e-06 ko05152 Tuberculosis 27/388 187/7206 2.17200188281e-06 ko05330 Allograft rejection 9/388 24/7206 2.20215557456e-06 ko04660 T cell receptor signaling pathway 21/388 124/7206 2.31286005177e-06 ko04612 Antigen processing and presentation 16/388 77/7206 2.42875623518e-06 ko04658 Th1 and Th2 cell differentiation 18/388 96/7206 2.75671855673e-06 ko05145 Toxoplasmosis 21/388 126/7206 3.0186325696e-06 ko05140 Leishmaniasis 15/388 75/7206 8.26171709719e-06 ko04217 Necroptosis 25/388 178/7206 8.59371311615e-06 ko04064 NF-kappa B signaling pathway 17/388 96/7206 1.16417802881e-05 ko05320 Autoimmune thyroid disease 9/388 29/7206 1.32548628458e-05 ko04662 B cell receptor signaling pathway 16/388 88/7206 1.48994532768e-05 ko04620 Toll-like receptor signaling pathway 17/388 100/7206 2.03644906842e-05 ko05332 Graft-versus-host disease 7/388 18/7206 2.35834828214e-05 ko05167 Kaposi's sarcoma-associated herpesvirus infection 25/388 191/7206 2.96308517835e-05 ko05168 Herpes simplex infection 24/388 182/7206 3.7835316198e-05 ko04659 Th17 cell differentiation 17/388 106/7206 4.43799248297e-05 ko05150 Staphylococcus aureus infection 9/388 36/7206 8.89979403896e-05 ko04137 Mitophagy - animal 14/388 82/7206 0.000104213928537 ko04080 Neuroactive ligand-receptor interaction 7/388 423/7206 0.000129470928141 ko04630 Jak-STAT signaling pathway 18/388 132/7206 0.00023103991402 ko04610 Complement and coagulation cascades 13/388 79/7206 0.000268277235963 ko00120 Primary bile acid biosynthesis 6/388 20/7206 0.000476399334486 ko04672 Intestinal immune network for IgA production 8/388 37/7206 0.00063867182832 ko05133 Pertussis 13/388 87/7206 0.000703338815566 ko04390 Hippo signaling pathway 1/388 188/7206 0.000769922374542 ko04145 Phagosome 19/388 162/7206 0.00118276409852 ko04062 Chemokine signaling pathway 22/388 201/7206 0.00128890215773 ko04940 Type I diabetes mellitus 7/388 32/7206 0.0012951860778 ko05310 Asthma 5/388 17/7206 0.00159221833316 ko04640 Hematopoietic cell lineage 10/388 64/7206 0.00202806055654 ko05142 Chagas disease (American trypanosomiasis) 16/388 130/7206 0.00227083224605 ko05144 Malaria 8/388 45/7206 0.00244566162772 ko04664 Fc epsilon RI signaling pathway 11/388 77/7206 0.00257740469411 ko05161 Hepatitis B 19/388 173/7206 0.00300387846921 ko04210 Apoptosis 19/388 180/7206 0.00411130124117 ko03040 Spliceosome 1/388 145/7206 0.00477316924322 ko04110 Cell cycle 1/388 145/7206 0.00477316924322 ko05160 Hepatitis C 17/388 153/7206 0.00532638502537 ko00140 Steroid hormone biosynthesis 7/388 41/7206 0.00570013989234 ko00051 Fructose and mannose metabolism 7/388 42/7206 0.00653173215668 ko04666 Fc gamma R-mediated phagocytosis 14/388 122/7206 0.00681864452494 ko05034 Alcoholism 4/388 238/7206 0.00766404218571 ko04611 Platelet activation 17/388 163/7206 0.00766972737132 ko03050 Proteasome 8/388 54/7206 0.00774473129271 ko05323 Rheumatoid arthritis 11/388 89/7206 0.00791754975657 ko05131 Shigellosis 10/388 82/7206 0.0121481153828 ko04668 TNF signaling pathway 13/388 120/7206 0.0133532224929 ko03010 Ribosome 1/388 129/7206 0.0155764850104 ko00592 alpha-Linolenic acid metabolism 4/388 19/7206 0.016838028842 ko04622 RIG-I-like receptor signaling pathway 8/388 62/7206 0.0173475040152 ko00590 Arachidonic acid metabolism 7/388 52/7206 0.0204706264934 ko05224 Breast cancer 3/388 174/7206 0.0257742511651 ko04723 Retrograde endocannabinoid signaling 3/388 175/7206 0.0258999298688 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 2/388 5/7206 0.0259442908131 ko00281 Geraniol degradation 2/388 5/7206 0.0259442908131 ko05416 Viral myocarditis 7/388 55/7206 0.0270823670454 ko04146 Peroxisome 10/388 89/7206 0.0277711612656 ko04514 Cell adhesion molecules (CAMs) 13/388 130/7206 0.0283586474069 ko04916 Melanogenesis 2/388 142/7206 0.0356385831612 ko05132 Salmonella infection 10/388 98/7206 0.041651837615 ko04670 Leukocyte transendothelial migration 14/388 151/7206 0.0427256585946 ko04350 TGF-beta signaling pathway 1/388 103/7206 0.044463840456 ko00982 Drug metabolism - cytochrome P450 5/388 37/7206 0.0465390644033 ko04728 Dopaminergic synapse 4/388 185/7206 0.0468244080123 ko04540 Gap junction 2/388 128/7206 0.0479457263063