ko pathway ratio_in_study ratio_in_pop p_value ko05340 Primary immunodeficiency 11/299 30/7206 1.41119318142e-08 ko04060 Cytokine-cytokine receptor interaction 25/299 191/7206 2.69979239084e-07 ko04650 Natural killer cell mediated cytotoxicity 17/299 97/7206 3.78765483409e-07 ko04630 Jak-STAT signaling pathway 18/299 132/7206 7.47681227682e-06 ko00120 Primary bile acid biosynthesis 7/299 20/7206 9.60213136877e-06 ko05162 Measles 16/299 120/7206 3.21176050197e-05 ko04640 Hematopoietic cell lineage 11/299 64/7206 5.43112521293e-05 ko05168 Herpes simplex infection 20/299 182/7206 5.99002798424e-05 ko04612 Antigen processing and presentation 12/299 77/7206 6.80819962542e-05 ko05321 Inflammatory bowel disease (IBD) 10/299 56/7206 8.48465658346e-05 ko04672 Intestinal immune network for IgA production 8/299 37/7206 0.000107812914952 ko04659 Th17 cell differentiation 14/299 106/7206 0.000111210055661 ko04380 Osteoclast differentiation 16/299 134/7206 0.000124319622923 ko04658 Th1 and Th2 cell differentiation 13/299 96/7206 0.000150988676083 ko05164 Influenza A 18/299 167/7206 0.000179513514437 ko04662 B cell receptor signaling pathway 12/299 88/7206 0.000252905551379 ko04610 Complement and coagulation cascades 11/299 79/7206 0.000379192054443 ko00950 Isoquinoline alkaloid biosynthesis 4/299 10/7206 0.000500277640475 ko05150 Staphylococcus aureus infection 7/299 36/7206 0.000583531958984 ko05145 Toxoplasmosis 14/299 126/7206 0.000687204546919 ko04621 NOD-like receptor signaling pathway 16/299 157/7206 0.000762262632825 ko05140 Leishmaniasis 10/299 75/7206 0.00098387761843 ko00350 Tyrosine metabolism 6/299 33/7206 0.0020827705882 ko05330 Allograft rejection 5/299 24/7206 0.00263709593984 ko00982 Drug metabolism - cytochrome P450 6/299 37/7206 0.00380409175123 ko04611 Platelet activation 15/299 163/7206 0.00397797934456 ko04664 Fc epsilon RI signaling pathway 9/299 77/7206 0.00436117816736 ko00360 Phenylalanine metabolism 4/299 17/7206 0.00450325393715 ko04390 Hippo signaling pathway 1/299 188/7206 0.00491270045909 ko04660 T cell receptor signaling pathway 12/299 124/7206 0.00519110161371 ko00590 Arachidonic acid metabolism 7/299 52/7206 0.0053069581725 ko05332 Graft-versus-host disease 4/299 18/7206 0.00560353398581 ko00980 Metabolism of xenobiotics by cytochrome P450 6/299 40/7206 0.00566040969589 ko05320 Autoimmune thyroid disease 5/299 29/7206 0.00621921808265 ko04064 NF-kappa B signaling pathway 10/299 96/7206 0.00623061795349 ko00140 Steroid hormone biosynthesis 6/299 41/7206 0.0064052119454 ko03050 Proteasome 7/299 54/7206 0.00654767215903 ko00592 alpha-Linolenic acid metabolism 4/299 19/7206 0.00686968262934 ko04310 Wnt signaling pathway 1/299 181/7206 0.00719024943373 ko00480 Glutathione metabolism 7/299 55/7206 0.00724332933129 ko03320 PPAR signaling pathway 8/299 69/7206 0.00740134120126 ko05152 Tuberculosis 16/299 187/7206 0.00767615045652 ko04710 Circadian rhythm 6/299 43/7206 0.00810450113554 ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis 2/299 4/7206 0.00973969629986 ko04146 Peroxisome 9/299 89/7206 0.0111615242301 ko04217 Necroptosis 15/299 178/7206 0.0112252900571 ko01524 Platinum drug resistance 8/299 76/7206 0.0130166201542 ko05204 Chemical carcinogenesis 6/299 48/7206 0.0137319194687 ko05167 Kaposi's sarcoma-associated herpesvirus infection 15/299 191/7206 0.015470924934 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 2/299 5/7206 0.0157897423147 ko00220 Arginine biosynthesis 4/299 24/7206 0.0160069476504 ko04666 Fc gamma R-mediated phagocytosis 11/299 122/7206 0.0176186185198 ko01040 Biosynthesis of unsaturated fatty acids 4/299 25/7206 0.0184489831289 ko04137 Mitophagy - animal 8/299 82/7206 0.0198990116061 ko04145 Phagosome 13/299 162/7206 0.0247654274072 ko05133 Pertussis 8/299 87/7206 0.0273529115186 ko04062 Chemokine signaling pathway 15/299 201/7206 0.0284789348128 ko00051 Fructose and mannose metabolism 5/299 42/7206 0.0288016553705 ko05310 Asthma 3/299 17/7206 0.0312259339015 ko04916 Melanogenesis 1/299 142/7206 0.031337477475 ko03040 Spliceosome 1/299 145/7206 0.031981632952 ko04670 Leukocyte transendothelial migration 12/299 151/7206 0.0346656311694 ko04728 Dopaminergic synapse 2/299 185/7206 0.0365464180882 ko04620 Toll-like receptor signaling pathway 9/299 100/7206 0.0365558729727 ko01212 Fatty acid metabolism 6/299 60/7206 0.0371745774355 ko05144 Malaria 5/299 45/7206 0.0374416512334 ko04136 Autophagy - other 4/299 31/7206 0.0378307979074 ko04940 Type I diabetes mellitus 4/299 32/7206 0.0418736826067 ko04622 RIG-I-like receptor signaling pathway 6/299 62/7206 0.0426520696107 ko03010 Ribosome 1/299 129/7206 0.0447918157283 ko05034 Alcoholism 4/299 238/7206 0.0473727783398