ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 26/173 191/7206 3.44550831397e-13 ko04621 NOD-like receptor signaling pathway 23/173 157/7206 1.87082020755e-12 ko04380 Osteoclast differentiation 21/173 134/7206 4.86668856884e-12 ko04064 NF-kappa B signaling pathway 18/173 96/7206 7.81136342194e-12 ko05145 Toxoplasmosis 19/173 126/7206 1.07971387456e-10 ko04217 Necroptosis 22/173 178/7206 1.82403172967e-10 ko05168 Herpes simplex infection 22/173 182/7206 2.82522014074e-10 ko05164 Influenza A 21/173 167/7206 3.52987636798e-10 ko05321 Inflammatory bowel disease (IBD) 13/173 56/7206 4.31629671886e-10 ko05152 Tuberculosis 21/173 187/7206 2.90552698679e-09 ko04658 Th1 and Th2 cell differentiation 15/173 96/7206 6.66121209336e-09 ko04630 Jak-STAT signaling pathway 17/173 132/7206 1.30279571392e-08 ko05340 Primary immunodeficiency 9/173 30/7206 1.99611597311e-08 ko04659 Th17 cell differentiation 15/173 106/7206 2.67926551017e-08 ko04660 T cell receptor signaling pathway 16/173 124/7206 3.47253057121e-08 ko05162 Measles 15/173 120/7206 1.45915304757e-07 ko05140 Leishmaniasis 12/173 75/7206 1.75672919744e-07 ko04622 RIG-I-like receptor signaling pathway 11/173 62/7206 1.95311106867e-07 ko04612 Antigen processing and presentation 12/173 77/7206 2.37025789796e-07 ko04620 Toll-like receptor signaling pathway 13/173 100/7206 6.47854363496e-07 ko05160 Hepatitis C 16/173 153/7206 6.67077617592e-07 ko05161 Hepatitis B 17/173 173/7206 7.16056876253e-07 ko05167 Kaposi's sarcoma-associated herpesvirus infection 17/173 191/7206 2.86228825371e-06 ko04650 Natural killer cell mediated cytotoxicity 12/173 97/7206 3.02972146353e-06 ko04668 TNF signaling pathway 13/173 120/7206 5.25590182265e-06 ko04662 B cell receptor signaling pathway 11/173 88/7206 7.15999670793e-06 ko05330 Allograft rejection 6/173 24/7206 1.64977606988e-05 ko04672 Intestinal immune network for IgA production 7/173 37/7206 2.2817275358e-05 ko05310 Asthma 5/173 17/7206 3.68577115362e-05 ko04623 Cytosolic DNA-sensing pathway 7/173 41/7206 4.59511581378e-05 ko05320 Autoimmune thyroid disease 6/173 29/7206 5.26963099318e-05 ko04210 Apoptosis 14/173 180/7206 9.9612425784e-05 ko04640 Hematopoietic cell lineage 8/173 64/7206 0.000132031287275 ko04611 Platelet activation 13/173 163/7206 0.000137837501682 ko05150 Staphylococcus aureus infection 6/173 36/7206 0.000187968077496 ko05416 Viral myocarditis 7/173 55/7206 0.000312644542925 ko04062 Chemokine signaling pathway 14/173 201/7206 0.000318349520308 ko05169 Epstein-Barr virus infection 14/173 206/7206 0.000409235305288 ko05332 Graft-versus-host disease 4/173 18/7206 0.00075444589752 ko05323 Rheumatoid arthritis 8/173 89/7206 0.00126691841694 ko04145 Phagosome 11/173 162/7206 0.00172274284874 ko03050 Proteasome 6/173 54/7206 0.00174462433762 ko04664 Fc epsilon RI signaling pathway 7/173 77/7206 0.0023816365516 ko04610 Complement and coagulation cascades 7/173 79/7206 0.00275818715045 ko04670 Leukocyte transendothelial migration 10/173 151/7206 0.00332678608922 ko05131 Shigellosis 7/173 82/7206 0.00340677885382 ko04514 Cell adhesion molecules (CAMs) 9/173 130/7206 0.00393743886845 ko05144 Malaria 5/173 45/7206 0.00422856765841 ko05166 HTLV-I infection 15/173 292/7206 0.00501759250152 ko04940 Type I diabetes mellitus 4/173 32/7206 0.00682683114268 ko05418 Fluid shear stress and atherosclerosis 10/173 173/7206 0.00859463490126 ko04666 Fc gamma R-mediated phagocytosis 8/173 122/7206 0.0088686840404 ko05142 Chagas disease (American trypanosomiasis) 8/173 130/7206 0.0127388005842 ko05215 Prostate cancer 7/173 111/7206 0.017097092841 ko04917 Prolactin signaling pathway 6/173 87/7206 0.0178610345504 ko04657 IL-17 signaling pathway 6/173 87/7206 0.0178610345504 ko05133 Pertussis 6/173 87/7206 0.0178610345504 ko05146 Amoebiasis 6/173 99/7206 0.0314021339111 ko04933 AGE-RAGE signaling pathway in diabetic complications 7/173 135/7206 0.0434499383007 ko05212 Pancreatic cancer 5/173 83/7206 0.0487814024131