ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 43/319 191/7206 1.37568597442e-19 ko05164 Influenza A 32/319 167/7206 9.97382354262e-13 ko05340 Primary immunodeficiency 14/319 30/7206 6.41640860055e-12 ko05162 Measles 26/319 120/7206 8.02705191756e-12 ko04064 NF-kappa B signaling pathway 23/319 96/7206 1.50029954885e-11 ko04380 Osteoclast differentiation 27/319 134/7206 1.90963687323e-11 ko04621 NOD-like receptor signaling pathway 29/319 157/7206 3.1694362653e-11 ko05168 Herpes simplex infection 31/319 182/7206 5.67215060907e-11 ko04650 Natural killer cell mediated cytotoxicity 22/319 97/7206 1.3410301982e-10 ko04217 Necroptosis 29/319 178/7206 7.31890602866e-10 ko05321 Inflammatory bowel disease (IBD) 16/319 56/7206 1.24607894971e-09 ko04620 Toll-like receptor signaling pathway 20/319 100/7206 9.81763993276e-09 ko05140 Leishmaniasis 17/319 75/7206 1.80416569291e-08 ko04659 Th17 cell differentiation 20/319 106/7206 2.79361404101e-08 ko04630 Jak-STAT signaling pathway 22/319 132/7206 5.90079119631e-08 ko05145 Toxoplasmosis 21/319 126/7206 1.19066556792e-07 ko04658 Th1 and Th2 cell differentiation 18/319 96/7206 1.55356123499e-07 ko05150 Staphylococcus aureus infection 11/319 36/7206 2.39705838972e-07 ko05152 Tuberculosis 25/319 187/7206 6.1298773032e-07 ko04612 Antigen processing and presentation 15/319 77/7206 1.03011733587e-06 ko04662 B cell receptor signaling pathway 16/319 88/7206 1.18916960514e-06 ko04610 Complement and coagulation cascades 15/319 79/7206 1.45242531454e-06 ko04660 T cell receptor signaling pathway 19/319 124/7206 1.82457999183e-06 ko04062 Chemokine signaling pathway 25/319 201/7206 2.38768668175e-06 ko04672 Intestinal immune network for IgA production 10/319 37/7206 3.00810606408e-06 ko05133 Pertussis 15/319 87/7206 5.13793613686e-06 ko05330 Allograft rejection 8/319 24/7206 5.33687949911e-06 ko04623 Cytosolic DNA-sensing pathway 10/319 41/7206 8.26534654255e-06 ko05167 Kaposi's sarcoma-associated herpesvirus infection 23/319 191/7206 1.05556663921e-05 ko05160 Hepatitis C 20/319 153/7206 1.18724111298e-05 ko04622 RIG-I-like receptor signaling pathway 12/319 62/7206 1.35213029108e-05 ko04640 Hematopoietic cell lineage 12/319 64/7206 1.89816484579e-05 ko05320 Autoimmune thyroid disease 8/319 29/7206 2.56441844534e-05 ko04668 TNF signaling pathway 16/319 120/7206 7.02198845473e-05 ko05161 Hepatitis B 20/319 173/7206 7.21112148236e-05 ko05332 Graft-versus-host disease 6/319 18/7206 8.48196411601e-05 ko04666 Fc gamma R-mediated phagocytosis 15/319 122/7206 0.000294608509805 ko05034 Alcoholism 1/319 238/7206 0.000342302108405 ko00590 Arachidonic acid metabolism 9/319 52/7206 0.000398154247241 ko05323 Rheumatoid arthritis 12/319 89/7206 0.00050784777928 ko05142 Chagas disease (American trypanosomiasis) 15/319 130/7206 0.000587207057435 ko05310 Asthma 5/319 17/7206 0.000656332927268 ko04145 Phagosome 17/319 162/7206 0.00078114004592 ko00120 Primary bile acid biosynthesis 5/319 20/7206 0.0014738022818 ko00140 Steroid hormone biosynthesis 7/319 41/7206 0.00191190498665 ko04664 Fc epsilon RI signaling pathway 10/319 77/7206 0.00196612897263 ko04940 Type I diabetes mellitus 6/319 32/7206 0.00245134110275 ko04210 Apoptosis 17/319 180/7206 0.00274815695628 ko05132 Salmonella infection 11/319 98/7206 0.00385220265193 ko04310 Wnt signaling pathway 1/319 181/7206 0.00502171819024 ko05134 Legionellosis 9/319 74/7206 0.00509909263898 ko05169 Epstein-Barr virus infection 18/319 206/7206 0.00520512293379 ko04611 Platelet activation 15/319 163/7206 0.00615361339974 ko04723 Retrograde endocannabinoid signaling 1/319 175/7206 0.00760224403478 ko04670 Leukocyte transendothelial migration 14/319 151/7206 0.00784348639996 ko00592 alpha-Linolenic acid metabolism 4/319 19/7206 0.00861601120199 ko03050 Proteasome 7/319 54/7206 0.00922458673528 ko05131 Shigellosis 9/319 82/7206 0.00993899640507 ko05416 Viral myocarditis 7/319 55/7206 0.0101807114609 ko05144 Malaria 6/319 45/7206 0.0136211250619 ko04657 IL-17 signaling pathway 9/319 87/7206 0.0143622241825 ko04724 Glutamatergic synapse 1/319 152/7206 0.01505158792 ko04390 Hippo signaling pathway 2/319 188/7206 0.0178642482665 ko03040 Spliceosome 1/319 145/7206 0.0221099284318 ko04110 Cell cycle 1/319 145/7206 0.0221099284318 ko05202 Transcriptional misregulation in cancer 15/319 188/7206 0.0281863730765 ko04713 Circadian entrainment 1/319 136/7206 0.0318732058871 ko04360 Axon guidance 4/319 233/7206 0.0350898918327 ko00966 Glucosinolate biosynthesis 1/319 1/7206 0.0442686650015 ko04514 Cell adhesion molecules (CAMs) 11/319 130/7206 0.0475395761965