ko pathway ratio_in_study ratio_in_pop p_value ko04721 Synaptic vesicle cycle 41/542 80/7206 1.33355858625e-25 ko05033 Nicotine addiction 32/542 56/7206 3.63294918154e-22 ko04724 Glutamatergic synapse 49/542 152/7206 1.70708230838e-19 ko04728 Dopaminergic synapse 52/542 185/7206 1.09203095917e-17 ko04080 Neuroactive ligand-receptor interaction 82/542 423/7206 1.98675440728e-16 ko04727 GABAergic synapse 37/542 110/7206 1.17475937377e-15 ko05032 Morphine addiction 37/542 110/7206 1.17475937377e-15 ko04723 Retrograde endocannabinoid signaling 45/542 175/7206 6.99384166076e-14 ko04713 Circadian entrainment 37/542 136/7206 2.01870387474e-12 ko04725 Cholinergic synapse 38/542 160/7206 8.84761859722e-11 ko04744 Phototransduction 16/542 36/7206 1.49978487433e-09 ko04024 cAMP signaling pathway 51/542 279/7206 1.62196224061e-09 ko04911 Insulin secretion 29/542 117/7206 5.61067692873e-09 ko04726 Serotonergic synapse 30/542 137/7206 6.54174420033e-08 ko04966 Collecting duct acid secretion 12/542 26/7206 1.05674600026e-07 ko05030 Cocaine addiction 20/542 73/7206 2.33963422264e-07 ko04261 Adrenergic signaling in cardiomyocytes 37/542 205/7206 4.79147994001e-07 ko05031 Amphetamine addiction 22/542 91/7206 6.37100882482e-07 ko04010 MAPK signaling pathway 49/542 321/7206 1.24354917361e-06 ko04921 Oxytocin signaling pathway 35/542 209/7206 6.03920156293e-06 ko05110 Vibrio cholerae infection 16/542 63/7206 1.10760396527e-05 ko05014 Amyotrophic lateral sclerosis (ALS) 16/542 74/7206 9.35075191169e-05 ko04720 Long-term potentiation 19/542 99/7206 0.000118147403231 ko05120 Epithelial cell signaling in Helicobacter pylori infection 18/542 92/7206 0.000137403451635 ko04970 Salivary secretion 18/542 95/7206 0.000210272946135 ko00604 Glycosphingolipid biosynthesis - ganglio series 6/542 14/7206 0.000313510258118 ko04260 Cardiac muscle contraction 18/542 98/7206 0.000314867533711 ko04961 Endocrine and other factor-regulated calcium reabsorption 13/542 59/7206 0.000344949610081 ko04060 Cytokine-cytokine receptor interaction 3/542 191/7206 0.000409786103866 ko05203 Viral carcinogenesis 7/542 277/7206 0.00043777893387 ko04120 Ubiquitin mediated proteolysis 1/542 138/7206 0.000453770453788 ko04730 Long-term depression 15/542 78/7206 0.000591980225484 ko05323 Rheumatoid arthritis 16/542 89/7206 0.000854327929771 ko04964 Proximal tubule bicarbonate reclamation 8/542 29/7206 0.00101256443909 ko05322 Systemic lupus erythematosus 2/542 151/7206 0.0014389830197 ko04360 Axon guidance 31/542 233/7206 0.00149731789655 ko04020 Calcium signaling pathway 34/542 265/7206 0.00185793724479 ko04514 Cell adhesion molecules (CAMs) 20/542 130/7206 0.00199540617746 ko03040 Spliceosome 2/542 145/7206 0.00203676267122 ko03013 RNA transport 3/542 166/7206 0.00244520767532 ko05205 Proteoglycans in cancer 9/542 271/7206 0.00467102347418 ko04742 Taste transduction 11/542 61/7206 0.00520956959419 ko04972 Pancreatic secretion 17/542 111/7206 0.00524492787956 ko04745 Phototransduction - fly 8/542 38/7206 0.0063333519024 ko05164 Influenza A 4/542 167/7206 0.00698008538377 ko04022 cGMP-PKG signaling pathway 27/542 216/7206 0.0082505945004 ko04510 Focal adhesion 8/542 240/7206 0.00867211099472 ko04971 Gastric acid secretion 15/542 98/7206 0.0101850702896 ko04973 Carbohydrate digestion and absorption 8/542 42/7206 0.0117327640861 ko04145 Phagosome 21/542 162/7206 0.0145632976921 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 12/542 79/7206 0.0163094708811 ko04072 Phospholipase D signaling pathway 24/542 197/7206 0.0187348809153 ko04141 Protein processing in endoplasmic reticulum 6/542 184/7206 0.0227557678613 ko04071 Sphingolipid signaling pathway 20/542 162/7206 0.0236341724706 ko04211 Longevity regulating pathway 3/542 123/7206 0.0245310889659 ko01200 Carbon metabolism 3/542 128/7206 0.0256551466899 ko04978 Mineral absorption 7/542 40/7206 0.0277676904794 ko04612 Antigen processing and presentation 1/542 77/7206 0.0289862554021 ko04610 Complement and coagulation cascades 1/542 79/7206 0.0293412840826 ko05168 Herpes simplex infection 6/542 182/7206 0.0310566234841 ko04960 Aldosterone-regulated sodium reabsorption 7/542 41/7206 0.0313956671717 ko04621 NOD-like receptor signaling pathway 5/542 157/7206 0.0320158391215 ko05162 Measles 3/542 120/7206 0.0342365714978 ko04144 Endocytosis 36/542 342/7206 0.0354221547948 ko04925 Aldosterone synthesis and secretion 14/542 105/7206 0.0369660664863 ko00190 Oxidative phosphorylation 16/542 127/7206 0.039410954147 ko05010 Alzheimer's disease 23/542 202/7206 0.04159991074 ko04214 Apoptosis - fly 1/542 72/7206 0.0419731399054 ko04915 Estrogen signaling pathway 16/542 131/7206 0.0451075491297 ko04630 Jak-STAT signaling pathway 4/542 132/7206 0.0451375020471