ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	159/875	423/7206	1.98963183053e-44
ko05033	Nicotine addiction	44/875	56/7206	2.56168496259e-30
ko04724	Glutamatergic synapse	75/875	152/7206	4.92577172142e-30
ko05032	Morphine addiction	57/875	110/7206	2.00317445063e-24
ko04727	GABAergic synapse	53/875	110/7206	7.01043776164e-21
ko04728	Dopaminergic synapse	71/875	185/7206	1.89696687212e-20
ko04713	Circadian entrainment	58/875	136/7206	1.7208209618e-19
ko04723	Retrograde endocannabinoid signaling	67/875	175/7206	2.77758439504e-19
ko04725	Cholinergic synapse	61/875	160/7206	1.5266025196e-17
ko04024	cAMP signaling pathway	84/875	279/7206	3.37067005488e-16
ko04721	Synaptic vesicle cycle	38/875	80/7206	4.73871762507e-15
ko04911	Insulin secretion	46/875	117/7206	4.25061949809e-14
ko04020	Calcium signaling pathway	76/875	265/7206	1.48999220869e-13
ko04726	Serotonergic synapse	49/875	137/7206	4.48576536937e-13
ko04742	Taste transduction	29/875	61/7206	8.39396408465e-12
ko04921	Oxytocin signaling pathway	61/875	209/7206	1.7529861892e-11
ko04360	Axon guidance	65/875	233/7206	3.28148213592e-11
ko04261	Adrenergic signaling in cardiomyocytes	58/875	205/7206	2.65860955696e-10
ko05031	Amphetamine addiction	34/875	91/7206	4.74788219988e-10
ko05030	Cocaine addiction	29/875	73/7206	1.71682889913e-09
ko04720	Long-term potentiation	33/875	99/7206	2.38135303089e-08
ko03040	Spliceosome	1/875	145/7206	2.23737284887e-07
ko04010	MAPK signaling pathway	71/875	321/7206	2.71482921779e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	25/875	74/7206	9.01578299966e-07
ko04925	Aldosterone synthesis and secretion	31/875	105/7206	1.32590336526e-06
ko04970	Salivary secretion	29/875	95/7206	1.36346146055e-06
ko05203	Viral carcinogenesis	11/875	277/7206	3.13107070376e-06
ko05322	Systemic lupus erythematosus	3/875	151/7206	7.33235706336e-06
ko04514	Cell adhesion molecules (CAMs)	34/875	130/7206	9.13882163901e-06
ko04971	Gastric acid secretion	28/875	98/7206	1.14519257126e-05
ko04060	Cytokine-cytokine receptor interaction	6/875	191/7206	1.48415033665e-05
ko04141	Protein processing in endoplasmic reticulum	6/875	184/7206	2.98872252717e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	23/875	79/7206	3.91139774821e-05
ko05168	Herpes simplex infection	6/875	182/7206	4.32421712277e-05
ko04972	Pancreatic secretion	29/875	111/7206	4.73346500619e-05
ko04022	cGMP-PKG signaling pathway	47/875	216/7206	4.81657894066e-05
ko03013	RNA transport	5/875	166/7206	5.37207877901e-05
ko04621	NOD-like receptor signaling pathway	5/875	157/7206	0.00010555573865
ko04961	Endocrine and other factor-regulated calcium reabsorption	18/875	59/7206	0.000138214523934
ko05164	Influenza A	6/875	167/7206	0.000167151245231
ko04120	Ubiquitin mediated proteolysis	4/875	138/7206	0.000183697050332
ko05414	Dilated cardiomyopathy	28/875	112/7206	0.00018410369365
ko04745	Phototransduction - fly	13/875	38/7206	0.00033444719787
ko04014	Ras signaling pathway	54/875	279/7206	0.000487406176173
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/875	14/7206	0.000601967599167
ko04744	Phototransduction	12/875	36/7206	0.000737344124693
ko03008	Ribosome biogenesis in eukaryotes	1/875	79/7206	0.000753833008383
ko04260	Cardiac muscle contraction	24/875	98/7206	0.000810531527628
ko00240	Pyrimidine metabolism	3/875	110/7206	0.000967945721126
ko04932	Non-alcoholic fatty liver disease (NAFLD)	9/875	182/7206	0.00122035442027
ko04730	Long-term depression	20/875	78/7206	0.00124185638165
ko04015	Rap1 signaling pathway	52/875	278/7206	0.00134562480065
ko04540	Gap junction	28/875	128/7206	0.0015322462007
ko04915	Estrogen signaling pathway	28/875	131/7206	0.00261271059452
ko00564	Glycerophospholipid metabolism	3/875	99/7206	0.00276404778978
ko04740	Olfactory transduction	19/875	80/7206	0.0031081893306
ko05169	Epstein-Barr virus infection	12/875	206/7206	0.00327993247247
ko04217	Necroptosis	10/875	178/7206	0.00499251256233
ko00330	Arginine and proline metabolism	1/875	61/7206	0.00538502628376
ko04072	Phospholipase D signaling pathway	37/875	197/7206	0.00559592925455
ko04964	Proximal tubule bicarbonate reclamation	9/875	29/7206	0.00576311996133
ko04350	TGF-beta signaling pathway	4/875	103/7206	0.00585967564515
ko05140	Leishmaniasis	2/875	75/7206	0.00688688520818
ko04612	Antigen processing and presentation	2/875	77/7206	0.00725823332164
ko04750	Inflammatory mediator regulation of TRP channels	25/875	122/7206	0.00740993511457
ko04924	Renin secretion	19/875	86/7206	0.00755031155499
ko04146	Peroxisome	3/875	89/7206	0.00795825060761
ko04976	Bile secretion	18/875	80/7206	0.00864591806606
ko04214	Apoptosis - fly	2/875	72/7206	0.00997646918938
ko00310	Lysine degradation	2/875	73/7206	0.0102227207828
ko05162	Measles	6/875	120/7206	0.0110508193671
ko04064	NF-kappa B signaling pathway	4/875	96/7206	0.0113381740081
ko04930	Type II diabetes mellitus	13/875	54/7206	0.0117463847968
ko00480	Glutathione metabolism	1/875	55/7206	0.0117600845766
ko05321	Inflammatory bowel disease (IBD)	1/875	56/7206	0.0119553251891
ko05205	Proteoglycans in cancer	20/875	271/7206	0.0133549833031
ko04218	Cellular senescence	11/875	177/7206	0.0137473394223
ko04630	Jak-STAT signaling pathway	7/875	132/7206	0.0145139249178
ko05161	Hepatitis B	11/875	173/7206	0.0177262410413
ko04916	Melanogenesis	27/875	142/7206	0.0184665794393
ko00190	Oxidative phosphorylation	7/875	127/7206	0.0189564029238
ko01200	Carbon metabolism	7/875	128/7206	0.0191955895379
ko04371	Apelin signaling pathway	32/875	177/7206	0.0192435530047
ko04640	Hematopoietic cell lineage	2/875	64/7206	0.0203008996055
ko05410	Hypertrophic cardiomyopathy (HCM)	20/875	100/7206	0.0203940934667
ko04962	Vasopressin-regulated water reabsorption	13/875	58/7206	0.0244232395607
ko05219	Bladder cancer	1/875	48/7206	0.0254521984171
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	5/875	15/7206	0.0276095538896
ko04110	Cell cycle	9/875	145/7206	0.0279313354097
ko05133	Pertussis	4/875	87/7206	0.03009838642
ko00561	Glycerolipid metabolism	2/875	63/7206	0.0301794274084
ko04670	Leukocyte transendothelial migration	10/875	151/7206	0.0323161953932
ko04923	Regulation of lipolysis in adipocytes	16/875	77/7206	0.032690045224
ko03022	Basal transcription factors	1/875	44/7206	0.0373798909413
ko05144	Malaria	1/875	45/7206	0.0374527961341
ko00071	Fatty acid degradation	1/875	45/7206	0.0374527961341
ko03420	Nucleotide excision repair	1/875	46/7206	0.038108344314
ko00270	Cysteine and methionine metabolism	1/875	47/7206	0.0393451264956
ko05131	Shigellosis	4/875	82/7206	0.0405990059737
ko03018	RNA degradation	4/875	84/7206	0.041497425719