ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 46/624 191/7206 7.10189915209e-11 ko04380 Osteoclast differentiation 35/624 134/7206 1.42208917252e-09 ko05340 Primary immunodeficiency 14/624 30/7206 4.54299517542e-08 ko04650 Natural killer cell mediated cytotoxicity 25/624 97/7206 4.33308821003e-07 ko04137 Mitophagy - animal 22/624 82/7206 1.02095805177e-06 ko00120 Primary bile acid biosynthesis 10/624 20/7206 1.83256756653e-06 ko05162 Measles 27/624 120/7206 2.72361882501e-06 ko05321 Inflammatory bowel disease (IBD) 17/624 56/7206 2.74422911322e-06 ko04064 NF-kappa B signaling pathway 23/624 96/7206 4.87366387215e-06 ko05164 Influenza A 33/624 167/7206 4.90997931169e-06 ko04610 Complement and coagulation cascades 20/624 79/7206 8.31099561597e-06 ko05152 Tuberculosis 35/624 187/7206 9.31466555302e-06 ko04621 NOD-like receptor signaling pathway 31/624 157/7206 9.81941515796e-06 ko04217 Necroptosis 33/624 178/7206 2.06632435643e-05 ko03040 Spliceosome 1/624 145/7206 3.97849249556e-05 ko03013 RNA transport 2/624 166/7206 6.55230955049e-05 ko05145 Toxoplasmosis 25/624 126/7206 7.19854964396e-05 ko04620 Toll-like receptor signaling pathway 21/624 100/7206 0.000101827390409 ko05167 Kaposi's sarcoma-associated herpesvirus infection 33/624 191/7206 0.000113443577601 ko04662 B cell receptor signaling pathway 19/624 88/7206 0.000146708018449 ko05140 Leishmaniasis 17/624 75/7206 0.000174129841595 ko03010 Ribosome 1/624 129/7206 0.000194467896504 ko04710 Circadian rhythm 12/624 43/7206 0.000199497958794 ko04659 Th17 cell differentiation 21/624 106/7206 0.000304735856182 ko04630 Jak-STAT signaling pathway 24/624 132/7206 0.000429845271099 ko04660 T cell receptor signaling pathway 23/624 124/7206 0.000499212298076 ko05320 Autoimmune thyroid disease 9/624 29/7206 0.000531339983751 ko05034 Alcoholism 7/624 238/7206 0.000582703564261 ko05330 Allograft rejection 8/624 24/7206 0.000635344046936 ko05144 Malaria 11/624 45/7206 0.00124241152594 ko04110 Cell cycle 3/624 145/7206 0.00158248804527 ko00140 Steroid hormone biosynthesis 10/624 41/7206 0.00208951442316 ko00051 Fructose and mannose metabolism 10/624 42/7206 0.00253451994896 ko04640 Hematopoietic cell lineage 13/624 64/7206 0.00285122880224 ko05150 Staphylococcus aureus infection 9/624 36/7206 0.00288519994929 ko04612 Antigen processing and presentation 15/624 77/7206 0.0030644366016 ko05332 Graft-versus-host disease 6/624 18/7206 0.00308657820726 ko05323 Rheumatoid arthritis 16/624 89/7206 0.00397296378765 ko04145 Phagosome 25/624 162/7206 0.00420544115543 ko04668 TNF signaling pathway 20/624 120/7206 0.00451586971796 ko05168 Herpes simplex infection 27/624 182/7206 0.00479486476496 ko04658 Th1 and Th2 cell differentiation 17/624 96/7206 0.00490273804907 ko04068 FoxO signaling pathway 25/624 167/7206 0.00736755447746 ko04933 AGE-RAGE signaling pathway in diabetic complications 21/624 135/7206 0.00778410533691 ko05418 Fluid shear stress and atherosclerosis 25/624 173/7206 0.00914956407977 ko05161 Hepatitis B 25/624 173/7206 0.00914956407977 ko04723 Retrograde endocannabinoid signaling 6/624 175/7206 0.00920960908009 ko04072 Phospholipase D signaling pathway 28/624 197/7206 0.00944366334994 ko04062 Chemokine signaling pathway 28/624 201/7206 0.0105496920656 ko05132 Salmonella infection 16/624 98/7206 0.0108960944357 ko04390 Hippo signaling pathway 7/624 188/7206 0.0118844764811 ko04672 Intestinal immune network for IgA production 8/624 37/7206 0.0122290900608 ko03320 PPAR signaling pathway 12/624 69/7206 0.0162621349014 ko01040 Biosynthesis of unsaturated fatty acids 6/624 25/7206 0.0174962489284 ko05160 Hepatitis C 22/624 153/7206 0.0186927939376 ko04622 RIG-I-like receptor signaling pathway 11/624 62/7206 0.0197785873833 ko00592 alpha-Linolenic acid metabolism 5/624 19/7206 0.0200194473981 ko00350 Tyrosine metabolism 7/624 33/7206 0.0206343687276 ko04623 Cytosolic DNA-sensing pathway 8/624 41/7206 0.0223087399347 ko04111 Cell cycle - yeast 2/624 90/7206 0.0225751602752 ko04066 HIF-1 signaling pathway 18/624 123/7206 0.0231411215761 ko03015 mRNA surveillance pathway 2/624 93/7206 0.0234567404077 ko04972 Pancreatic secretion 3/624 111/7206 0.0248304502398 ko00983 Drug metabolism - other enzymes 8/624 42/7206 0.0255421851407 ko04670 Leukocyte transendothelial migration 21/624 151/7206 0.0273049749058 ko05224 Breast cancer 7/624 174/7206 0.0277652851473 ko05217 Basal cell carcinoma 1/624 68/7206 0.0282763397024 ko04113 Meiosis - yeast 1/624 70/7206 0.0292139401083 ko00982 Drug metabolism - cytochrome P450 7/624 37/7206 0.0368771090918 ko05322 Systemic lupus erythematosus 6/624 151/7206 0.0392432548888 ko05142 Chagas disease (American trypanosomiasis) 18/624 130/7206 0.040275453804 ko04070 Phosphatidylinositol signaling system 16/624 112/7206 0.0409548900752 ko00590 Arachidonic acid metabolism 9/624 52/7206 0.0415601187203 ko04310 Wnt signaling pathway 8/624 181/7206 0.0432450741727 ko04136 Autophagy - other 6/624 31/7206 0.046849975061 ko04550 Signaling pathways regulating pluripotency of stem cells 7/624 165/7206 0.0480788691799 ko04022 cGMP-PKG signaling pathway 27/624 216/7206 0.0486386409092 ko00950 Isoquinoline alkaloid biosynthesis 3/624 10/7206 0.0489143532005 ko04666 Fc gamma R-mediated phagocytosis 17/624 122/7206 0.0490604284581