ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 35/314 152/7206 1.22387034042e-16 ko04080 Neuroactive ligand-receptor interaction 57/314 423/7206 5.04912895169e-15 ko05033 Nicotine addiction 20/314 56/7206 6.32684249754e-14 ko04728 Dopaminergic synapse 34/314 185/7206 4.14080707467e-13 ko04727 GABAergic synapse 25/314 110/7206 4.70014631374e-12 ko04723 Retrograde endocannabinoid signaling 29/314 175/7206 3.31125254878e-10 ko05032 Morphine addiction 22/314 110/7206 1.29765238721e-09 ko04713 Circadian entrainment 23/314 136/7206 1.63007845976e-08 ko04726 Serotonergic synapse 23/314 137/7206 1.88249079589e-08 ko04725 Cholinergic synapse 24/314 160/7206 8.70132127542e-08 ko04024 cAMP signaling pathway 33/314 279/7206 1.23111322051e-07 ko05030 Cocaine addiction 15/314 73/7206 4.07125636499e-07 ko04721 Synaptic vesicle cycle 14/314 80/7206 7.41332477345e-06 ko05031 Amphetamine addiction 14/314 91/7206 3.40188575323e-05 ko04514 Cell adhesion molecules (CAMs) 17/314 130/7206 4.40190385837e-05 ko04742 Taste transduction 11/314 61/7206 5.3487639619e-05 ko04010 MAPK signaling pathway 29/314 321/7206 0.000196593360935 ko04020 Calcium signaling pathway 25/314 265/7206 0.00028699117681 ko04730 Long-term depression 11/314 78/7206 0.000513785957131 ko04911 Insulin secretion 14/314 117/7206 0.00052646729603 ko04261 Adrenergic signaling in cardiomyocytes 20/314 205/7206 0.000674822288359 ko05205 Proteoglycans in cancer 2/314 271/7206 0.000723515273535 ko05203 Viral carcinogenesis 2/314 277/7206 0.000748640610734 ko04720 Long-term potentiation 12/314 99/7206 0.00116176407272 ko05014 Amyotrophic lateral sclerosis (ALS) 10/314 74/7206 0.00128500502879 ko05034 Alcoholism 21/314 238/7206 0.00181953522691 ko04921 Oxytocin signaling pathway 18/314 209/7206 0.00515977193944 ko04014 Ras signaling pathway 22/314 279/7206 0.00643087147101 ko04964 Proximal tubule bicarbonate reclamation 5/314 29/7206 0.00762880715838 ko04260 Cardiac muscle contraction 10/314 98/7206 0.010000286529 ko05322 Systemic lupus erythematosus 1/314 151/7206 0.0149221437123 ko04744 Phototransduction 5/314 36/7206 0.018908355174 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 8/314 79/7206 0.0211080683735 ko04110 Cell cycle 1/314 145/7206 0.0217374226199 ko04970 Salivary secretion 9/314 95/7206 0.0221457719484 ko04217 Necroptosis 2/314 178/7206 0.0248531930378 ko04540 Gap junction 11/314 128/7206 0.0266648189197 ko04930 Type II diabetes mellitus 6/314 54/7206 0.0290533937435 ko04972 Pancreatic secretion 10/314 111/7206 0.0293167337511 ko04072 Phospholipase D signaling pathway 15/314 197/7206 0.0319195728706 ko05210 Colorectal cancer 8/314 86/7206 0.0331277204651 ko04961 Endocrine and other factor-regulated calcium reabsorption 6/314 59/7206 0.042386635686 ko02025 Biofilm formation - Pseudomonas aeruginosa 1/314 1/7206 0.043574798779