ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 92/551 423/7206 1.65388044646e-21 ko04721 Synaptic vesicle cycle 37/551 80/7206 5.91878619651e-21 ko04724 Glutamatergic synapse 47/551 152/7206 1.27926888418e-17 ko05033 Nicotine addiction 28/551 56/7206 2.8355813719e-17 ko04728 Dopaminergic synapse 49/551 185/7206 2.729602664e-15 ko04727 GABAergic synapse 36/551 110/7206 1.29073644367e-14 ko05032 Morphine addiction 35/551 110/7206 7.96519342472e-14 ko04713 Circadian entrainment 38/551 136/7206 6.73597572236e-13 ko04725 Cholinergic synapse 41/551 160/7206 1.86027489332e-12 ko04723 Retrograde endocannabinoid signaling 42/551 175/7206 1.0282593999e-11 ko05031 Amphetamine addiction 27/551 91/7206 3.57808438872e-10 ko04911 Insulin secretion 31/551 117/7206 4.13427135819e-10 ko04966 Collecting duct acid secretion 14/551 26/7206 8.13668158006e-10 ko05030 Cocaine addiction 23/551 73/7206 2.0028134536e-09 ko04726 Serotonergic synapse 31/551 137/7206 2.55794186749e-08 ko04720 Long-term potentiation 23/551 99/7206 1.01315944875e-06 ko04024 cAMP signaling pathway 44/551 279/7206 2.84389458474e-06 ko05110 Vibrio cholerae infection 17/551 63/7206 2.99010429908e-06 ko05120 Epithelial cell signaling in Helicobacter pylori infection 21/551 92/7206 4.04853257928e-06 ko04261 Adrenergic signaling in cardiomyocytes 35/551 205/7206 5.71584685048e-06 ko04970 Salivary secretion 21/551 95/7206 6.9520528233e-06 ko05014 Amyotrophic lateral sclerosis (ALS) 18/551 74/7206 7.67397592445e-06 ko05168 Herpes simplex infection 1/551 182/7206 1.31947500978e-05 ko04924 Renin secretion 18/551 86/7206 6.77453415002e-05 ko04742 Taste transduction 14/551 61/7206 0.000154345410659 ko04921 Oxytocin signaling pathway 32/551 209/7206 0.000158439108795 ko03040 Spliceosome 1/551 145/7206 0.000204271623673 ko05164 Influenza A 2/551 167/7206 0.000312534184372 ko04260 Cardiac muscle contraction 18/551 98/7206 0.00038497975594 ko04961 Endocrine and other factor-regulated calcium reabsorption 13/551 59/7206 0.000404883843346 ko04730 Long-term depression 15/551 78/7206 0.000703440235399 ko05322 Systemic lupus erythematosus 2/551 151/7206 0.000943087762999 ko04964 Proximal tubule bicarbonate reclamation 8/551 29/7206 0.00112815814526 ko04971 Gastric acid secretion 17/551 98/7206 0.00147887093821 ko04626 Plant-pathogen interaction 6/551 18/7206 0.00162789362787 ko03013 RNA transport 3/551 166/7206 0.00165855593241 ko04010 MAPK signaling pathway 40/551 321/7206 0.00174021618677 ko00190 Oxidative phosphorylation 20/551 127/7206 0.00188135868559 ko04972 Pancreatic secretion 18/551 111/7206 0.00188896603476 ko04540 Gap junction 20/551 128/7206 0.00199886458461 ko04514 Cell adhesion molecules (CAMs) 20/551 130/7206 0.00227958369751 ko05034 Alcoholism 31/551 238/7206 0.00280012881897 ko04020 Calcium signaling pathway 34/551 265/7206 0.00291952337611 ko04621 NOD-like receptor signaling pathway 3/551 157/7206 0.00337497839287 ko05323 Rheumatoid arthritis 15/551 89/7206 0.00361766343431 ko04744 Phototransduction 8/551 36/7206 0.00494695229506 ko04022 cGMP-PKG signaling pathway 28/551 216/7206 0.00576871274446 ko04145 Phagosome 22/551 162/7206 0.00686568240422 ko04745 Phototransduction - fly 8/551 38/7206 0.00698533374645 ko04925 Aldosterone synthesis and secretion 16/551 105/7206 0.00797165333879 ko04976 Bile secretion 13/551 80/7206 0.00884746047627 ko04120 Ubiquitin mediated proteolysis 3/551 138/7206 0.00910322479104 ko04060 Cytokine-cytokine receptor interaction 6/551 191/7206 0.0127015101939 ko05010 Alzheimer's disease 25/551 202/7206 0.0150079499557 ko05166 HTLV-I infection 12/551 292/7206 0.0177768735347 ko04510 Focal adhesion 9/551 240/7206 0.0182800344736 ko04611 Platelet activation 5/551 163/7206 0.0240480098828 ko04922 Glucagon signaling pathway 17/551 128/7206 0.0267743554668 ko04612 Antigen processing and presentation 1/551 77/7206 0.0290431109134 ko04610 Complement and coagulation cascades 1/551 79/7206 0.0298413299553 ko04978 Mineral absorption 7/551 40/7206 0.0300501733463 ko04064 NF-kappa B signaling pathway 2/551 96/7206 0.032675572528 ko05203 Viral carcinogenesis 12/551 277/7206 0.0369021909298 ko04014 Ras signaling pathway 31/551 279/7206 0.0374632521829 ko00680 Methane metabolism 6/551 34/7206 0.0416749637348 ko00310 Lysine degradation 1/551 73/7206 0.0426682229963 ko04371 Apelin signaling pathway 21/551 177/7206 0.0432528763172 ko04310 Wnt signaling pathway 21/551 181/7206 0.0473566597084