ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 37/304 191/7206 2.12302070295e-15 ko05340 Primary immunodeficiency 15/304 30/7206 1.48625813108e-13 ko05140 Leishmaniasis 18/304 75/7206 1.17094277453e-09 ko04380 Osteoclast differentiation 24/304 134/7206 1.23943568379e-09 ko04650 Natural killer cell mediated cytotoxicity 20/304 97/7206 2.44345236689e-09 ko05321 Inflammatory bowel disease (IBD) 15/304 56/7206 5.74277309711e-09 ko05145 Toxoplasmosis 22/304 126/7206 1.01936524201e-08 ko05320 Autoimmune thyroid disease 11/304 29/7206 1.10364371932e-08 ko04659 Th17 cell differentiation 20/304 106/7206 1.23438642487e-08 ko04658 Th1 and Th2 cell differentiation 19/304 96/7206 1.26872514895e-08 ko05330 Allograft rejection 10/304 24/7206 1.78753405149e-08 ko04672 Intestinal immune network for IgA production 12/304 37/7206 1.83801117374e-08 ko04640 Hematopoietic cell lineage 15/304 64/7206 4.1476328525e-08 ko05152 Tuberculosis 26/304 187/7206 6.23292027577e-08 ko04612 Antigen processing and presentation 16/304 77/7206 8.99464338981e-08 ko05150 Staphylococcus aureus infection 11/304 36/7206 1.46980546733e-07 ko05332 Graft-versus-host disease 8/304 18/7206 2.76941863389e-07 ko05164 Influenza A 23/304 167/7206 4.41606060534e-07 ko05168 Herpes simplex infection 24/304 182/7206 5.57487817793e-07 ko04064 NF-kappa B signaling pathway 16/304 96/7206 2.10266142059e-06 ko04660 T cell receptor signaling pathway 18/304 124/7206 3.82329797084e-06 ko04610 Complement and coagulation cascades 14/304 79/7206 4.36813504416e-06 ko04621 NOD-like receptor signaling pathway 20/304 157/7206 8.58668915641e-06 ko04630 Jak-STAT signaling pathway 18/304 132/7206 9.40918343672e-06 ko05162 Measles 17/304 120/7206 9.96669234019e-06 ko04062 Chemokine signaling pathway 23/304 201/7206 1.12012345802e-05 ko04620 Toll-like receptor signaling pathway 15/304 100/7206 1.66065388094e-05 ko04940 Type I diabetes mellitus 8/304 32/7206 3.96549958093e-05 ko05310 Asthma 6/304 17/7206 4.47739834114e-05 ko05133 Pertussis 13/304 87/7206 6.35287251293e-05 ko05323 Rheumatoid arthritis 13/304 89/7206 8.09093962627e-05 ko04145 Phagosome 18/304 162/7206 0.000150022311109 ko04622 RIG-I-like receptor signaling pathway 10/304 62/7206 0.000235156091244 ko04662 B cell receptor signaling pathway 12/304 88/7206 0.000294702558829 ko04217 Necroptosis 18/304 178/7206 0.000485219621861 ko05144 Malaria 8/304 45/7206 0.000503770988359 ko05034 Alcoholism 1/304 238/7206 0.000769925149221 ko04514 Cell adhesion molecules (CAMs) 14/304 130/7206 0.00110299533767 ko00120 Primary bile acid biosynthesis 5/304 20/7206 0.00118774047168 ko05167 Kaposi's sarcoma-associated herpesvirus infection 18/304 191/7206 0.00135474939318 ko00590 Arachidonic acid metabolism 8/304 52/7206 0.00136121068921 ko05161 Hepatitis B 17/304 173/7206 0.00148602860777 ko05416 Viral myocarditis 8/304 55/7206 0.00197388181288 ko04611 Platelet activation 16/304 163/7206 0.00217979401548 ko04360 Axon guidance 2/304 233/7206 0.00438825764427 ko04664 Fc epsilon RI signaling pathway 9/304 77/7206 0.00486050828111 ko04728 Dopaminergic synapse 1/304 185/7206 0.00490700354639 ko04666 Fc gamma R-mediated phagocytosis 12/304 122/7206 0.00519394174279 ko04670 Leukocyte transendothelial migration 14/304 151/7206 0.00589285397229 ko00140 Steroid hormone biosynthesis 6/304 41/7206 0.00693418785459 ko04723 Retrograde endocannabinoid signaling 1/304 175/7206 0.00712879186996 ko03050 Proteasome 7/304 54/7206 0.00715372455339 ko04310 Wnt signaling pathway 1/304 181/7206 0.00736249315447 ko05224 Breast cancer 1/304 174/7206 0.0110206642597 ko05142 Chagas disease (American trypanosomiasis) 12/304 130/7206 0.0120535424495 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 2/304 5/7206 0.0163000245253 ko05131 Shigellosis 8/304 82/7206 0.0217458271894 ko05132 Salmonella infection 9/304 98/7206 0.0220437395481 ko04724 Glutamatergic synapse 1/304 152/7206 0.0221543453077 ko04390 Hippo signaling pathway 2/304 188/7206 0.025261324656 ko05020 Prion diseases 5/304 40/7206 0.0253707203636 ko00980 Metabolism of xenobiotics by cytochrome P450 5/304 40/7206 0.0253707203636 ko04623 Cytosolic DNA-sensing pathway 5/304 41/7206 0.0279313498788 ko00601 Glycosphingolipid biosynthesis - lacto and neolacto series 4/304 28/7206 0.0285923420415 ko03040 Spliceosome 1/304 145/7206 0.0328090452956 ko04110 Cell cycle 1/304 145/7206 0.0328090452956 ko05202 Transcriptional misregulation in cancer 14/304 188/7206 0.0396945459832 ko00592 alpha-Linolenic acid metabolism 3/304 19/7206 0.0436574908762 ko04922 Glucagon signaling pathway 1/304 128/7206 0.0447493958439 ko03010 Ribosome 1/304 129/7206 0.0448288228049 ko04713 Circadian entrainment 1/304 136/7206 0.0474141643248