ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	208/1206	423/7206	9.20654858904e-58
ko05033	Nicotine addiction	49/1206	56/7206	2.76454190966e-31
ko04724	Glutamatergic synapse	88/1206	152/7206	3.44033204455e-31
ko05032	Morphine addiction	69/1206	110/7206	1.28100710808e-27
ko04727	GABAergic synapse	67/1206	110/7206	9.20982108657e-26
ko04713	Circadian entrainment	75/1206	136/7206	7.24477319498e-25
ko04728	Dopaminergic synapse	85/1206	185/7206	5.20987424677e-21
ko04020	Calcium signaling pathway	107/1206	265/7206	9.25601409367e-21
ko04721	Synaptic vesicle cycle	50/1206	80/7206	3.22706607125e-20
ko04024	cAMP signaling pathway	107/1206	279/7206	9.30599196756e-19
ko04725	Cholinergic synapse	74/1206	160/7206	1.25729059017e-18
ko04723	Retrograde endocannabinoid signaling	78/1206	175/7206	2.1833021074e-18
ko04911	Insulin secretion	57/1206	117/7206	6.93877996805e-16
ko04742	Taste transduction	38/1206	61/7206	1.35811087207e-15
ko04921	Oxytocin signaling pathway	80/1206	209/7206	4.39135382687e-14
ko04726	Serotonergic synapse	59/1206	137/7206	2.18842330861e-13
ko04744	Phototransduction	26/1206	36/7206	2.36675435713e-13
ko04970	Salivary secretion	45/1206	95/7206	2.90456437438e-12
ko04261	Adrenergic signaling in cardiomyocytes	75/1206	205/7206	3.35211767763e-12
ko03040	Spliceosome	1/1206	145/7206	1.17168145525e-10
ko05031	Amphetamine addiction	41/1206	91/7206	1.94953511833e-10
ko04720	Long-term potentiation	43/1206	99/7206	2.98525088015e-10
ko04740	Olfactory transduction	37/1206	80/7206	6.03082419196e-10
ko04360	Axon guidance	76/1206	233/7206	1.75784798105e-09
ko05203	Viral carcinogenesis	14/1206	277/7206	3.12259730507e-09
ko04022	cGMP-PKG signaling pathway	69/1206	216/7206	2.55673393657e-08
ko04925	Aldosterone synthesis and secretion	41/1206	105/7206	3.70854406993e-08
ko05168	Herpes simplex infection	7/1206	182/7206	9.25366382733e-08
ko04060	Cytokine-cytokine receptor interaction	8/1206	191/7206	1.11523610322e-07
ko04971	Gastric acid secretion	38/1206	98/7206	1.45392379863e-07
ko05164	Influenza A	6/1206	167/7206	1.54742661077e-07
ko05322	Systemic lupus erythematosus	5/1206	151/7206	3.84523251126e-07
ko05030	Cocaine addiction	30/1206	73/7206	6.39760432431e-07
ko03013	RNA transport	7/1206	166/7206	8.53302135952e-07
ko04120	Ubiquitin mediated proteolysis	5/1206	138/7206	2.5610424428e-06
ko04972	Pancreatic secretion	38/1206	111/7206	7.58159598367e-06
ko05169	Epstein-Barr virus infection	13/1206	206/7206	1.04359934939e-05
ko04621	NOD-like receptor signaling pathway	8/1206	157/7206	1.20247960011e-05
ko04610	Complement and coagulation cascades	1/1206	79/7206	1.26925897758e-05
ko04924	Renin secretion	31/1206	86/7206	1.34686347646e-05
ko04141	Protein processing in endoplasmic reticulum	11/1206	184/7206	1.4104967794e-05
ko04070	Phosphatidylinositol signaling system	37/1206	112/7206	1.8609422684e-05
ko04540	Gap junction	41/1206	128/7206	1.96732246342e-05
ko04010	MAPK signaling pathway	83/1206	321/7206	2.27661713531e-05
ko05205	Proteoglycans in cancer	22/1206	271/7206	4.19211567965e-05
ko04745	Phototransduction - fly	17/1206	38/7206	4.78525889994e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1206	79/7206	4.97469775538e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	27/1206	74/7206	5.07933691518e-05
ko04976	Bile secretion	28/1206	80/7206	6.08029488618e-05
ko04514	Cell adhesion molecules (CAMs)	40/1206	130/7206	6.89884026881e-05
ko04966	Collecting duct acid secretion	13/1206	26/7206	9.16788379658e-05
ko04260	Cardiac muscle contraction	32/1206	98/7206	9.8534146021e-05
ko04730	Long-term depression	27/1206	78/7206	0.000100441730794
ko03008	Ribosome biogenesis in eukaryotes	2/1206	79/7206	0.000110629720302
ko05110	Vibrio cholerae infection	23/1206	63/7206	0.000127663028461
ko04961	Endocrine and other factor-regulated calcium reabsorption	22/1206	59/7206	0.000134795664554
ko04612	Antigen processing and presentation	2/1206	77/7206	0.000165594400588
ko05140	Leishmaniasis	2/1206	75/7206	0.000249698268012
ko04110	Cell cycle	9/1206	145/7206	0.000269434938719
ko04064	NF-kappa B signaling pathway	4/1206	96/7206	0.000271459311706
ko05414	Dilated cardiomyopathy	34/1206	112/7206	0.000296633287048
ko04750	Inflammatory mediator regulation of TRP channels	36/1206	122/7206	0.000350803247883
ko05162	Measles	7/1206	120/7206	0.000490364816722
ko05161	Hepatitis B	13/1206	173/7206	0.000593039900802
ko04146	Peroxisome	4/1206	89/7206	0.000825384866629
ko04072	Phospholipase D signaling pathway	51/1206	197/7206	0.000932129751652
ko04371	Apelin signaling pathway	47/1206	177/7206	0.000997448154508
ko04640	Hematopoietic cell lineage	2/1206	64/7206	0.00118919290287
ko04014	Ras signaling pathway	67/1206	279/7206	0.00138340653557
ko04964	Proximal tubule bicarbonate reclamation	12/1206	29/7206	0.00145513359397
ko00240	Pyrimidine metabolism	7/1206	110/7206	0.00182850430399
ko04214	Apoptosis - fly	3/1206	72/7206	0.00215621408852
ko04932	Non-alcoholic fatty liver disease (NAFLD)	16/1206	182/7206	0.00244283403895
ko00330	Arginine and proline metabolism	2/1206	61/7206	0.00274231662009
ko04657	IL-17 signaling pathway	5/1206	87/7206	0.00349959698671
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1206	14/7206	0.00417059815206
ko05410	Hypertrophic cardiomyopathy (HCM)	28/1206	100/7206	0.00425590934901
ko00071	Fatty acid degradation	1/1206	45/7206	0.00433212295944
ko03420	Nucleotide excision repair	1/1206	46/7206	0.00446100925482
ko05215	Prostate cancer	8/1206	111/7206	0.00455346171657
ko01524	Platinum drug resistance	4/1206	76/7206	0.00481766550358
ko03018	RNA degradation	5/1206	84/7206	0.00488308493559
ko05145	Toxoplasmosis	10/1206	126/7206	0.00540470222718
ko00480	Glutathione metabolism	2/1206	55/7206	0.00564889450576
ko05321	Inflammatory bowel disease (IBD)	2/1206	56/7206	0.00589980057031
ko05166	HTLV-I infection	32/1206	292/7206	0.00633461158023
ko04620	Toll-like receptor signaling pathway	7/1206	100/7206	0.0065115855326
ko04630	Jak-STAT signaling pathway	11/1206	132/7206	0.00662588297297
ko05131	Shigellosis	5/1206	82/7206	0.00683956495885
ko03022	Basal transcription factors	1/1206	44/7206	0.00688477851673
ko00590	Arachidonic acid metabolism	2/1206	52/7206	0.00818168133115
ko04923	Regulation of lipolysis in adipocytes	22/1206	77/7206	0.00845713527636
ko04330	Notch signaling pathway	3/1206	62/7206	0.00926717096808
ko04622	RIG-I-like receptor signaling pathway	3/1206	62/7206	0.00926717096808
ko00380	Tryptophan metabolism	2/1206	50/7206	0.0120619445225
ko04658	Th1 and Th2 cell differentiation	7/1206	96/7206	0.0123237712695
ko04915	Estrogen signaling pathway	33/1206	131/7206	0.0126459191351
ko04668	TNF signaling pathway	10/1206	120/7206	0.0129222789744
ko05418	Fluid shear stress and atherosclerosis	17/1206	173/7206	0.0129428677656
ko05133	Pertussis	6/1206	87/7206	0.0130098371119
ko04217	Necroptosis	18/1206	178/7206	0.01449917845
ko04140	Autophagy - animal	16/1206	164/7206	0.0145138304859
ko04210	Apoptosis	18/1206	180/7206	0.0147316481458
ko00630	Glyoxylate and dicarboxylate metabolism	1/1206	38/7206	0.0147677821523
ko00260	Glycine, serine and threonine metabolism	2/1206	48/7206	0.0178522064065
ko05219	Bladder cancer	2/1206	48/7206	0.0178522064065
ko04115	p53 signaling pathway	5/1206	74/7206	0.0180804678128
ko00310	Lysine degradation	5/1206	73/7206	0.0180823328018
ko04626	Plant-pathogen interaction	7/1206	18/7206	0.0209455001864
ko04270	Vascular smooth muscle contraction	37/1206	154/7206	0.0212259999429
ko05222	Small cell lung cancer	7/1206	89/7206	0.0216766705671
ko00500	Starch and sucrose metabolism	1/1206	35/7206	0.0219100864065
ko05144	Malaria	2/1206	45/7206	0.0254569836153
ko00280	Valine, leucine and isoleucine degradation	3/1206	54/7206	0.0263864411627
ko04922	Glucagon signaling pathway	31/1206	128/7206	0.0305688966559
ko05206	MicroRNAs in cancer	19/1206	177/7206	0.0317228660895
ko04350	TGF-beta signaling pathway	9/1206	103/7206	0.0321713867195
ko04978	Mineral absorption	12/1206	40/7206	0.0324311013118
ko04113	Meiosis - yeast	5/1206	70/7206	0.0346230836499
ko00983	Drug metabolism - other enzymes	2/1206	42/7206	0.0364100748086
ko05212	Pancreatic cancer	7/1206	83/7206	0.0386020286615
ko04918	Thyroid hormone synthesis	22/1206	86/7206	0.0402155805471
ko05132	Salmonella infection	9/1206	98/7206	0.0412177433984
ko04930	Type II diabetes mellitus	15/1206	54/7206	0.0416830641435
ko01200	Carbon metabolism	13/1206	128/7206	0.042395513517
ko04142	Lysosome	16/1206	151/7206	0.0464806280149
ko04015	Rap1 signaling pathway	59/1206	278/7206	0.0487826927252
ko04912	GnRH signaling pathway	29/1206	122/7206	0.0491049723294