ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	152/836	423/7206	3.63406730747e-42
ko04724	Glutamatergic synapse	84/836	152/7206	4.89578911468e-40
ko05033	Nicotine addiction	47/836	56/7206	9.07844991222e-36
ko04727	GABAergic synapse	61/836	110/7206	2.36989837014e-29
ko05032	Morphine addiction	61/836	110/7206	2.36989837014e-29
ko04713	Circadian entrainment	66/836	136/7206	3.66433264486e-27
ko04728	Dopaminergic synapse	78/836	185/7206	7.70246041115e-27
ko04723	Retrograde endocannabinoid signaling	71/836	175/7206	2.70387719331e-23
ko04725	Cholinergic synapse	65/836	160/7206	1.947745635e-21
ko04024	cAMP signaling pathway	84/836	279/7206	1.41573704925e-17
ko04911	Insulin secretion	49/836	117/7206	4.48775810484e-17
ko05031	Amphetamine addiction	40/836	91/7206	5.01382403986e-15
ko05030	Cocaine addiction	35/836	73/7206	9.98971310176e-15
ko04020	Calcium signaling pathway	76/836	265/7206	1.38064981759e-14
ko04726	Serotonergic synapse	50/836	137/7206	1.6682769868e-14
ko04921	Oxytocin signaling pathway	63/836	209/7206	1.8976091629e-13
ko04720	Long-term potentiation	39/836	99/7206	8.21919974728e-13
ko04261	Adrenergic signaling in cardiomyocytes	61/836	205/7206	8.8081353623e-13
ko04010	MAPK signaling pathway	81/836	321/7206	3.21263844408e-12
ko04742	Taste transduction	28/836	61/7206	1.84071934363e-11
ko04721	Synaptic vesicle cycle	31/836	80/7206	3.09343488774e-10
ko04970	Salivary secretion	33/836	95/7206	2.30151515046e-09
ko04925	Aldosterone synthesis and secretion	35/836	105/7206	2.65362317505e-09
ko04730	Long-term depression	27/836	78/7206	7.24964263812e-08
ko04971	Gastric acid secretion	31/836	98/7206	8.58301909945e-08
ko04972	Pancreatic secretion	33/836	111/7206	1.7337389652e-07
ko04072	Phospholipase D signaling pathway	49/836	197/7206	1.79987273797e-07
ko04540	Gap junction	36/836	128/7206	3.45289434481e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	25/836	74/7206	3.77382798804e-07
ko03040	Spliceosome	1/836	145/7206	5.47783567776e-07
ko04360	Axon guidance	52/836	233/7206	2.06939996204e-06
ko04915	Estrogen signaling pathway	34/836	131/7206	5.16303778952e-06
ko04022	cGMP-PKG signaling pathway	48/836	216/7206	6.7598657302e-06
ko04060	Cytokine-cytokine receptor interaction	5/836	191/7206	9.28577181718e-06
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	23/836	79/7206	1.86773573032e-05
ko05414	Dilated cardiomyopathy	29/836	112/7206	2.05715566251e-05
ko04514	Cell adhesion molecules (CAMs)	32/836	130/7206	3.84612461305e-05
ko05322	Systemic lupus erythematosus	4/836	151/7206	9.30360744795e-05
ko05034	Alcoholism	47/836	238/7206	0.000189812926666
ko05203	Viral carcinogenesis	14/836	277/7206	0.000242679719005
ko04961	Endocrine and other factor-regulated calcium reabsorption	17/836	59/7206	0.000259859927378
ko04912	GnRH signaling pathway	28/836	122/7206	0.000301959826862
ko04750	Inflammatory mediator regulation of TRP channels	28/836	122/7206	0.000301959826862
ko05168	Herpes simplex infection	7/836	182/7206	0.000365255315743
ko04744	Phototransduction	12/836	36/7206	0.000485061058407
ko03013	RNA transport	6/836	166/7206	0.000493361791307
ko04014	Ras signaling pathway	52/836	279/7206	0.000536691479153
ko04740	Olfactory transduction	20/836	80/7206	0.000663057275336
ko04260	Cardiac muscle contraction	23/836	98/7206	0.00072555060522
ko04015	Rap1 signaling pathway	51/836	278/7206	0.000761727049777
ko03018	RNA degradation	1/836	84/7206	0.000814804341949
ko04923	Regulation of lipolysis in adipocytes	19/836	77/7206	0.00106029626547
ko03008	Ribosome biogenesis in eukaryotes	1/836	79/7206	0.00115393793971
ko00240	Pyrimidine metabolism	3/836	110/7206	0.00137615805177
ko04612	Antigen processing and presentation	1/836	77/7206	0.00178929881269
ko04924	Renin secretion	20/836	86/7206	0.00190677949308
ko04918	Thyroid hormone synthesis	20/836	86/7206	0.00190677949308
ko04062	Chemokine signaling pathway	38/836	201/7206	0.00232803850792
ko04110	Cell cycle	6/836	145/7206	0.00238944452065
ko04070	Phosphatidylinositol signaling system	24/836	112/7206	0.0025493273705
ko04371	Apelin signaling pathway	34/836	177/7206	0.00273148131882
ko04350	TGF-beta signaling pathway	3/836	103/7206	0.00280573890776
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/836	14/7206	0.00315694599604
ko05231	Choline metabolism in cancer	27/836	134/7206	0.00381066930928
ko04930	Type II diabetes mellitus	14/836	54/7206	0.00396261802015
ko04071	Sphingolipid signaling pathway	31/836	162/7206	0.00414300437286
ko00190	Oxidative phosphorylation	5/836	127/7206	0.00460763990136
ko04270	Vascular smooth muscle contraction	30/836	154/7206	0.00465058963974
ko04916	Melanogenesis	28/836	142/7206	0.00490949553886
ko04640	Hematopoietic cell lineage	1/836	64/7206	0.00550993819409
ko00515	Mannose type O-glycan biosynthesis	8/836	25/7206	0.0056308925003
ko04932	Non-alcoholic fatty liver disease (NAFLD)	10/836	182/7206	0.00671142843776
ko04141	Protein processing in endoplasmic reticulum	10/836	184/7206	0.00684385752334
ko04621	NOD-like receptor signaling pathway	8/836	157/7206	0.00767572752135
ko00330	Arginine and proline metabolism	1/836	61/7206	0.00814020481831
ko04012	ErbB signaling pathway	22/836	109/7206	0.00939342548253
ko04745	Phototransduction - fly	10/836	38/7206	0.00950626515869
ko04146	Peroxisome	3/836	89/7206	0.011322453033
ko04722	Neurotrophin signaling pathway	29/836	160/7206	0.0123696742887
ko04976	Bile secretion	17/836	80/7206	0.0124714425428
ko04142	Lysosome	8/836	151/7206	0.0138219998309
ko00512	Mucin type O-glycan biosynthesis	8/836	29/7206	0.0147065487096
ko05410	Hypertrophic cardiomyopathy (HCM)	20/836	100/7206	0.0168002144484
ko05016	Huntington's disease	14/836	215/7206	0.0168476344316
ko00520	Amino sugar and nucleotide sugar metabolism	1/836	55/7206	0.0179066788768
ko00480	Glutathione metabolism	1/836	55/7206	0.0179066788768
ko05321	Inflammatory bowel disease (IBD)	1/836	56/7206	0.018443278146
ko05164	Influenza A	10/836	167/7206	0.0196427165027
ko04666	Fc gamma R-mediated phagocytosis	23/836	122/7206	0.0211586693334
ko01200	Carbon metabolism	7/836	128/7206	0.0254116436056
ko04213	Longevity regulating pathway - multiple species	17/836	86/7206	0.0258998057915
ko03460	Fanconi anemia pathway	1/836	51/7206	0.0260569563792
ko04120	Ubiquitin mediated proteolysis	8/836	138/7206	0.0308547511733
ko04144	Endocytosis	52/836	342/7206	0.0376140225654
ko03420	Nucleotide excision repair	1/836	46/7206	0.0379385777273
ko04962	Vasopressin-regulated water reabsorption	12/836	58/7206	0.0383766865451
ko05204	Chemical carcinogenesis	1/836	48/7206	0.0385452410064
ko00260	Glycine, serine and threonine metabolism	1/836	48/7206	0.0385452410064
ko01212	Fatty acid metabolism	2/836	60/7206	0.0418271257356
ko05205	Proteoglycans in cancer	21/836	271/7206	0.0422536099509
ko04217	Necroptosis	12/836	178/7206	0.0430009768117
ko04114	Oocyte meiosis	24/836	139/7206	0.0437587312553
ko05162	Measles	7/836	120/7206	0.0440950521385
ko01521	EGFR tyrosine kinase inhibitor resistance	19/836	106/7206	0.0466816266845
ko04960	Aldosterone-regulated sodium reabsorption	9/836	41/7206	0.0482571904163