ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	165/1025	423/7206	4.84659675912e-39
ko04724	Glutamatergic synapse	79/1025	152/7206	9.49782638591e-29
ko05033	Nicotine addiction	44/1025	56/7206	2.40510034829e-27
ko04727	GABAergic synapse	59/1025	110/7206	1.24401047333e-22
ko05032	Morphine addiction	59/1025	110/7206	1.24401047333e-22
ko04721	Synaptic vesicle cycle	48/1025	80/7206	1.86962090511e-21
ko04728	Dopaminergic synapse	76/1025	185/7206	1.08459358102e-19
ko04713	Circadian entrainment	62/1025	136/7206	5.4890601855e-19
ko04723	Retrograde endocannabinoid signaling	71/1025	175/7206	4.19759511783e-18
ko04725	Cholinergic synapse	65/1025	160/7206	1.0642659684e-16
ko04742	Taste transduction	34/1025	61/7206	3.1976137169e-14
ko04024	cAMP signaling pathway	88/1025	279/7206	6.1736557697e-14
ko04744	Phototransduction	25/1025	36/7206	6.42789551366e-14
ko04726	Serotonergic synapse	51/1025	137/7206	1.22545976308e-11
ko04911	Insulin secretion	46/1025	117/7206	1.40079215964e-11
ko04921	Oxytocin signaling pathway	65/1025	209/7206	2.44133405277e-10
ko05203	Viral carcinogenesis	9/1025	277/7206	1.12941457324e-09
ko04261	Adrenergic signaling in cardiomyocytes	61/1025	205/7206	5.64267640165e-09
ko03040	Spliceosome	1/1025	145/7206	9.30051134402e-09
ko04720	Long-term potentiation	36/1025	99/7206	2.73191124503e-08
ko04020	Calcium signaling pathway	71/1025	265/7206	4.54755819327e-08
ko05031	Amphetamine addiction	33/1025	91/7206	1.11985287456e-07
ko04740	Olfactory transduction	29/1025	80/7206	6.63691041633e-07
ko04971	Gastric acid secretion	33/1025	98/7206	1.07795894665e-06
ko05168	Herpes simplex infection	6/1025	182/7206	1.41499830037e-06
ko05164	Influenza A	5/1025	167/7206	1.60860876098e-06
ko04120	Ubiquitin mediated proteolysis	3/1025	138/7206	1.84326681896e-06
ko03013	RNA transport	5/1025	166/7206	2.46698522968e-06
ko04060	Cytokine-cytokine receptor interaction	7/1025	191/7206	2.5127439193e-06
ko04970	Salivary secretion	31/1025	95/7206	4.14019848081e-06
ko04360	Axon guidance	59/1025	233/7206	5.5348632697e-06
ko05030	Cocaine addiction	25/1025	73/7206	1.24613413299e-05
ko05322	Systemic lupus erythematosus	5/1025	151/7206	1.53277777909e-05
ko04966	Collecting duct acid secretion	13/1025	26/7206	1.55267245055e-05
ko05205	Proteoglycans in cancer	16/1025	271/7206	1.72194516242e-05
ko04514	Cell adhesion molecules (CAMs)	37/1025	130/7206	1.97072503334e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/1025	79/7206	2.39151081214e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	25/1025	74/7206	2.73300120093e-05
ko04925	Aldosterone synthesis and secretion	31/1025	105/7206	5.10886239371e-05
ko04972	Pancreatic secretion	32/1025	111/7206	5.19077758975e-05
ko05169	Epstein-Barr virus infection	11/1025	206/7206	6.52119341655e-05
ko03008	Ribosome biogenesis in eukaryotes	1/1025	79/7206	0.000129382809925
ko04010	MAPK signaling pathway	70/1025	321/7206	0.00015766198141
ko04260	Cardiac muscle contraction	28/1025	98/7206	0.000197816788303
ko05161	Hepatitis B	9/1025	173/7206	0.00023253850528
ko04141	Protein processing in endoplasmic reticulum	10/1025	184/7206	0.000234529759351
ko04976	Bile secretion	24/1025	80/7206	0.000265297836868
ko04621	NOD-like receptor signaling pathway	8/1025	157/7206	0.000310580152552
ko04964	Proximal tubule bicarbonate reclamation	12/1025	29/7206	0.000321298744414
ko04730	Long-term depression	23/1025	78/7206	0.000444496994217
ko05162	Measles	5/1025	120/7206	0.000521094933052
ko04022	cGMP-PKG signaling pathway	49/1025	216/7206	0.00069880173375
ko04070	Phosphatidylinositol signaling system	29/1025	112/7206	0.000933372937487
ko05140	Leishmaniasis	2/1025	75/7206	0.00138574174089
ko04745	Phototransduction - fly	13/1025	38/7206	0.00154652618313
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1025	14/7206	0.00158638739155
ko04072	Phospholipase D signaling pathway	44/1025	197/7206	0.00179123709103
ko04214	Apoptosis - fly	2/1025	72/7206	0.00202831513267
ko05414	Dilated cardiomyopathy	28/1025	112/7206	0.00236148954972
ko03018	RNA degradation	3/1025	84/7206	0.00244863988482
ko04924	Renin secretion	23/1025	86/7206	0.00263057858057
ko04064	NF-kappa B signaling pathway	4/1025	96/7206	0.0027976668715
ko00480	Glutathione metabolism	1/1025	55/7206	0.00328586388054
ko05166	HTLV-I infection	25/1025	292/7206	0.00353815783181
ko05410	Hypertrophic cardiomyopathy (HCM)	25/1025	100/7206	0.0036171251128
ko04932	Non-alcoholic fatty liver disease (NAFLD)	13/1025	182/7206	0.00362193337891
ko04110	Cell cycle	9/1025	145/7206	0.0036489904246
ko04961	Endocrine and other factor-regulated calcium reabsorption	17/1025	59/7206	0.00391573866799
ko00590	Arachidonic acid metabolism	1/1025	52/7206	0.00490732062962
ko04630	Jak-STAT signaling pathway	8/1025	132/7206	0.00521105232799
ko04146	Peroxisome	4/1025	89/7206	0.00539676331478
ko00240	Pyrimidine metabolism	6/1025	110/7206	0.00549787042195
ko04640	Hematopoietic cell lineage	2/1025	64/7206	0.00628395619321
ko04915	Estrogen signaling pathway	30/1025	131/7206	0.00744819641161
ko04140	Autophagy - animal	12/1025	164/7206	0.00887505690523
ko00330	Arginine and proline metabolism	2/1025	61/7206	0.00910501283014
ko05145	Toxoplasmosis	8/1025	126/7206	0.00940618329707
ko05110	Vibrio cholerae infection	17/1025	63/7206	0.00966296790575
ko04540	Gap junction	29/1025	128/7206	0.00997931850122
ko04137	Mitophagy - animal	4/1025	82/7206	0.0104760519779
ko04014	Ras signaling pathway	55/1025	279/7206	0.0109223927615
ko05219	Bladder cancer	1/1025	48/7206	0.0110743779515
ko01200	Carbon metabolism	9/1025	128/7206	0.0150938719616
ko03022	Basal transcription factors	1/1025	44/7206	0.0160918273091
ko05144	Malaria	1/1025	45/7206	0.0163784763743
ko00071	Fatty acid degradation	1/1025	45/7206	0.0163784763743
ko04668	TNF signaling pathway	8/1025	120/7206	0.016729454857
ko03420	Nucleotide excision repair	1/1025	46/7206	0.0170679152086
ko04933	AGE-RAGE signaling pathway in diabetic complications	10/1025	135/7206	0.0181081702834
ko05321	Inflammatory bowel disease (IBD)	2/1025	56/7206	0.0192814689346
ko04612	Antigen processing and presentation	4/1025	77/7206	0.020400046283
ko04217	Necroptosis	15/1025	178/7206	0.0223551211879
ko04210	Apoptosis	15/1025	180/7206	0.0225780353135
ko04658	Th1 and Th2 cell differentiation	6/1025	96/7206	0.0258945004272
ko04622	RIG-I-like receptor signaling pathway	3/1025	62/7206	0.0282710156186
ko00561	Glycerolipid metabolism	3/1025	63/7206	0.0283679656619
ko00280	Valine, leucine and isoleucine degradation	2/1025	54/7206	0.0285791720214
ko05215	Prostate cancer	8/1025	111/7206	0.0286161413738
ko04626	Plant-pathogen interaction	6/1025	18/7206	0.033061670377
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1025	40/7206	0.0369141915505
ko05131	Shigellosis	5/1025	82/7206	0.0369567890448
ko04371	Apelin signaling pathway	35/1025	177/7206	0.0380171108005
ko00380	Tryptophan metabolism	2/1025	50/7206	0.0395634095589
ko04620	Toll-like receptor signaling pathway	7/1025	100/7206	0.0419775391829
ko04930	Type II diabetes mellitus	13/1025	54/7206	0.0484159121662
ko04218	Cellular senescence	16/1025	177/7206	0.0491384510932
ko05206	MicroRNAs in cancer	16/1025	177/7206	0.0491384510932
ko05120	Epithelial cell signaling in Helicobacter pylori infection	20/1025	92/7206	0.049172545054