ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	177/1051	423/7206	1.75843625762e-45
ko05033	Nicotine addiction	50/1051	56/7206	7.62277966674e-36
ko04724	Glutamatergic synapse	86/1051	152/7206	4.18714871711e-34
ko05032	Morphine addiction	70/1051	110/7206	1.87972515915e-32
ko04727	GABAergic synapse	66/1051	110/7206	1.92806755922e-28
ko04713	Circadian entrainment	72/1051	136/7206	3.09860416651e-26
ko04728	Dopaminergic synapse	80/1051	185/7206	1.14279668959e-21
ko04723	Retrograde endocannabinoid signaling	77/1051	175/7206	1.86923302041e-21
ko04725	Cholinergic synapse	71/1051	160/7206	4.0759359935e-20
ko04024	cAMP signaling pathway	94/1051	279/7206	2.48860418674e-16
ko04744	Phototransduction	27/1051	36/7206	4.96641469094e-16
ko04721	Synaptic vesicle cycle	42/1051	80/7206	1.31722505608e-15
ko04911	Insulin secretion	52/1051	117/7206	4.48917141456e-15
ko04742	Taste transduction	35/1051	61/7206	8.63420790552e-15
ko04020	Calcium signaling pathway	87/1051	265/7206	2.2622691099e-14
ko04921	Oxytocin signaling pathway	72/1051	209/7206	3.4587531055e-13
ko04726	Serotonergic synapse	53/1051	137/7206	2.24018610956e-12
ko04261	Adrenergic signaling in cardiomyocytes	68/1051	205/7206	1.21752653901e-11
ko05031	Amphetamine addiction	39/1051	91/7206	4.95422121402e-11
ko04720	Long-term potentiation	40/1051	99/7206	2.48910184255e-10
ko04740	Olfactory transduction	33/1051	80/7206	5.0178287972e-09
ko04925	Aldosterone synthesis and secretion	38/1051	105/7206	2.62068158229e-08
ko03040	Spliceosome	2/1051	145/7206	6.57308705778e-08
ko05030	Cocaine addiction	29/1051	73/7206	1.15487607386e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1051	74/7206	1.63876531586e-07
ko04970	Salivary secretion	34/1051	95/7206	1.93856674112e-07
ko05203	Viral carcinogenesis	14/1051	277/7206	5.24469155373e-07
ko04971	Gastric acid secretion	33/1051	98/7206	1.62388862986e-06
ko04022	cGMP-PKG signaling pathway	57/1051	216/7206	4.83398843306e-06
ko03013	RNA transport	6/1051	166/7206	5.82662727752e-06
ko05322	Systemic lupus erythematosus	5/1051	151/7206	6.84075109976e-06
ko04010	MAPK signaling pathway	76/1051	321/7206	1.03995489398e-05
ko04072	Phospholipase D signaling pathway	52/1051	197/7206	1.26951662825e-05
ko04972	Pancreatic secretion	34/1051	111/7206	1.53359699875e-05
ko05168	Herpes simplex infection	8/1051	182/7206	1.53754591664e-05
ko04060	Cytokine-cytokine receptor interaction	9/1051	191/7206	1.60041453512e-05
ko04621	NOD-like receptor signaling pathway	6/1051	157/7206	1.70013937698e-05
ko05164	Influenza A	7/1051	167/7206	1.91443988296e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/1051	79/7206	3.31351018757e-05
ko04745	Phototransduction - fly	16/1051	38/7206	3.4963778249e-05
ko04514	Cell adhesion molecules (CAMs)	37/1051	130/7206	4.14236600193e-05
ko04360	Axon guidance	57/1051	233/7206	6.17298676566e-05
ko04141	Protein processing in endoplasmic reticulum	10/1051	184/7206	0.000118156000657
ko04260	Cardiac muscle contraction	29/1051	98/7206	0.000123685795613
ko04612	Antigen processing and presentation	1/1051	77/7206	0.000125389049662
ko04120	Ubiquitin mediated proteolysis	6/1051	138/7206	0.000205037698068
ko04730	Long-term depression	24/1051	78/7206	0.000256200147672
ko04070	Phosphatidylinositol signaling system	31/1051	112/7206	0.000347514719286
ko03008	Ribosome biogenesis in eukaryotes	2/1051	79/7206	0.00062839716879
ko05414	Dilated cardiomyopathy	30/1051	112/7206	0.00063429352539
ko04110	Cell cycle	8/1051	145/7206	0.000791409404843
ko05205	Proteoglycans in cancer	21/1051	271/7206	0.00079177337206
ko05161	Hepatitis B	11/1051	173/7206	0.000988607377268
ko04924	Renin secretion	24/1051	86/7206	0.00110260759829
ko04976	Bile secretion	23/1051	80/7206	0.00110890758132
ko05140	Leishmaniasis	2/1051	75/7206	0.00140310867598
ko05162	Measles	6/1051	120/7206	0.00151494910809
ko04750	Inflammatory mediator regulation of TRP channels	31/1051	122/7206	0.00164751515335
ko04064	NF-kappa B signaling pathway	4/1051	96/7206	0.0019061099954
ko04966	Collecting duct acid secretion	10/1051	26/7206	0.0023912932464
ko04915	Estrogen signaling pathway	32/1051	131/7206	0.00249308971344
ko00480	Glutathione metabolism	1/1051	55/7206	0.00326568133413
ko04540	Gap junction	31/1051	128/7206	0.00338775855459
ko04610	Complement and coagulation cascades	3/1051	79/7206	0.00344120518629
ko05169	Epstein-Barr virus infection	16/1051	206/7206	0.00352484961696
ko04146	Peroxisome	4/1051	89/7206	0.00373904215221
ko04930	Type II diabetes mellitus	16/1051	54/7206	0.00536738501316
ko04964	Proximal tubule bicarbonate reclamation	10/1051	29/7206	0.00597023804825
ko04371	Apelin signaling pathway	39/1051	177/7206	0.00675363155706
ko00230	Purine metabolism	42/1051	194/7206	0.00706410406561
ko04710	Circadian rhythm	13/1051	43/7206	0.00765939892194
ko04923	Regulation of lipolysis in adipocytes	20/1051	77/7206	0.00840414357688
ko04630	Jak-STAT signaling pathway	9/1051	132/7206	0.0085237915805
ko00562	Inositol phosphate metabolism	22/1051	89/7206	0.00979077481708
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1051	14/7206	0.00998405760851
ko03420	Nucleotide excision repair	1/1051	46/7206	0.0107084181195
ko04014	Ras signaling pathway	56/1051	279/7206	0.011788548626
ko00240	Pyrimidine metabolism	7/1051	110/7206	0.0133412187453
ko04210	Apoptosis	15/1051	180/7206	0.0136894439052
ko05166	HTLV-I infection	28/1051	292/7206	0.0137728199166
ko05016	Huntington's disease	19/1051	215/7206	0.0138877031783
ko05410	Hypertrophic cardiomyopathy (HCM)	24/1051	100/7206	0.0142023008738
ko05133	Pertussis	5/1051	87/7206	0.0142074714523
ko04922	Glucagon signaling pathway	29/1051	128/7206	0.0154823806998
ko03022	Basal transcription factors	1/1051	44/7206	0.0162183933626
ko05144	Malaria	1/1051	45/7206	0.0169691351356
ko00071	Fatty acid degradation	1/1051	45/7206	0.0169691351356
ko04142	Lysosome	12/1051	151/7206	0.0191019163242
ko05110	Vibrio cholerae infection	16/1051	63/7206	0.0196470301678
ko04115	p53 signaling pathway	4/1051	74/7206	0.0199806477333
ko05224	Breast cancer	15/1051	174/7206	0.0221201394197
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1051	40/7206	0.0235517980578
ko04961	Endocrine and other factor-regulated calcium reabsorption	15/1051	59/7206	0.0250241130065
ko05131	Shigellosis	5/1051	82/7206	0.026603271355
ko04214	Apoptosis - fly	4/1051	72/7206	0.0277998915975
ko04622	RIG-I-like receptor signaling pathway	3/1051	62/7206	0.0282945616185
ko00310	Lysine degradation	4/1051	73/7206	0.0283507254164
ko04711	Circadian rhythm - fly	5/1051	13/7206	0.0304830947263
ko04217	Necroptosis	16/1051	178/7206	0.0311832139541
ko04062	Chemokine signaling pathway	40/1051	201/7206	0.0334346205028
ko00982	Drug metabolism - cytochrome P450	1/1051	37/7206	0.0348532257932
ko00630	Glyoxylate and dicarboxylate metabolism	1/1051	38/7206	0.0352686617935
ko03410	Base excision repair	1/1051	38/7206	0.0352686617935
ko04626	Plant-pathogen interaction	6/1051	18/7206	0.0369073813246
ko05217	Basal cell carcinoma	4/1051	68/7206	0.0380183143073
ko03320	PPAR signaling pathway	4/1051	69/7206	0.0382389873479
ko05219	Bladder cancer	2/1051	48/7206	0.0386747604014
ko05200	Pathways in cancer	56/1051	492/7206	0.0399710573359
ko04510	Focal adhesion	24/1051	240/7206	0.0405364712358
ko04658	Th1 and Th2 cell differentiation	7/1051	96/7206	0.040943948809
ko04932	Non-alcoholic fatty liver disease (NAFLD)	17/1051	182/7206	0.0429023465301
ko04657	IL-17 signaling pathway	6/1051	87/7206	0.0453257683623