ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	120/708	423/7206	3.2888181826e-29
ko05033	Nicotine addiction	40/708	56/7206	1.62069479855e-28
ko04724	Glutamatergic synapse	64/708	152/7206	3.39294529902e-26
ko05032	Morphine addiction	50/708	110/7206	1.77823724172e-22
ko04727	GABAergic synapse	49/708	110/7206	1.43143973572e-21
ko04721	Synaptic vesicle cycle	38/708	80/7206	3.60215531752e-18
ko04723	Retrograde endocannabinoid signaling	58/708	175/7206	8.0374669513e-18
ko04728	Dopaminergic synapse	59/708	185/7206	3.27814954411e-17
ko04713	Circadian entrainment	48/708	136/7206	3.63780211455e-16
ko04024	cAMP signaling pathway	70/708	279/7206	3.91565721314e-14
ko04725	Cholinergic synapse	47/708	160/7206	1.843443986e-12
ko04911	Insulin secretion	36/708	117/7206	1.8342081285e-10
ko04261	Adrenergic signaling in cardiomyocytes	51/708	205/7206	1.90692697168e-10
ko05030	Cocaine addiction	25/708	73/7206	1.01982783493e-08
ko04020	Calcium signaling pathway	54/708	265/7206	1.35746161622e-07
ko04742	Taste transduction	21/708	61/7206	1.40620985052e-07
ko04921	Oxytocin signaling pathway	45/708	209/7206	3.3737466688e-07
ko04514	Cell adhesion molecules (CAMs)	32/708	130/7206	6.4513321119e-07
ko04726	Serotonergic synapse	33/708	137/7206	7.35526678665e-07
ko05031	Amphetamine addiction	25/708	91/7206	1.25850087254e-06
ko04010	MAPK signaling pathway	59/708	321/7206	1.78787728652e-06
ko04970	Salivary secretion	25/708	95/7206	2.9824526545e-06
ko03040	Spliceosome	1/708	145/7206	7.35056319531e-06
ko04966	Collecting duct acid secretion	11/708	26/7206	1.4789492907e-05
ko04360	Axon guidance	44/708	233/7206	1.62449516044e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	20/708	74/7206	1.89235119535e-05
ko04915	Estrogen signaling pathway	29/708	131/7206	2.11844953838e-05
ko04720	Long-term potentiation	24/708	99/7206	2.13351596027e-05
ko04972	Pancreatic secretion	26/708	111/7206	2.82312634799e-05
ko04060	Cytokine-cytokine receptor interaction	4/708	191/7206	3.60367576838e-05
ko04730	Long-term depression	20/708	78/7206	4.35624580018e-05
ko05168	Herpes simplex infection	4/708	182/7206	7.37754939009e-05
ko05203	Viral carcinogenesis	10/708	277/7206	0.000118958889462
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/708	14/7206	0.000158754355334
ko04022	cGMP-PKG signaling pathway	39/708	216/7206	0.000163820776
ko04072	Phospholipase D signaling pathway	36/708	197/7206	0.000219893223467
ko05322	Systemic lupus erythematosus	3/708	151/7206	0.000253681364439
ko05110	Vibrio cholerae infection	16/708	63/7206	0.000281409931456
ko05205	Proteoglycans in cancer	11/708	271/7206	0.000531852662366
ko04540	Gap junction	25/708	128/7206	0.000763659976256
ko03013	RNA transport	5/708	166/7206	0.00133433815783
ko04260	Cardiac muscle contraction	20/708	98/7206	0.00157728384844
ko04924	Renin secretion	18/708	86/7206	0.00159597410041
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	17/708	79/7206	0.00169853077128
ko04744	Phototransduction	10/708	36/7206	0.00186974185087
ko05414	Dilated cardiomyopathy	22/708	112/7206	0.00188702021127
ko04621	NOD-like receptor signaling pathway	5/708	157/7206	0.00254805719924
ko04971	Gastric acid secretion	19/708	98/7206	0.00323310042074
ko04120	Ubiquitin mediated proteolysis	4/708	138/7206	0.00339692302007
ko05164	Influenza A	6/708	167/7206	0.00353801501107
ko04925	Aldosterone synthesis and secretion	20/708	105/7206	0.00413155544165
ko03008	Ribosome biogenesis in eukaryotes	1/708	79/7206	0.00635676360793
ko04071	Sphingolipid signaling pathway	27/708	162/7206	0.00689298713538
ko04141	Protein processing in endoplasmic reticulum	8/708	184/7206	0.0081198852631
ko04214	Apoptosis - fly	1/708	72/7206	0.00872603668428
ko04070	Phosphatidylinositol signaling system	20/708	112/7206	0.00923282898486
ko04923	Regulation of lipolysis in adipocytes	15/708	77/7206	0.0103055968131
ko04146	Peroxisome	2/708	89/7206	0.0108880223172
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	5/708	15/7206	0.011737445959
ko05120	Epithelial cell signaling in Helicobacter pylori infection	17/708	92/7206	0.0118256208079
ko04014	Ras signaling pathway	40/708	279/7206	0.0134556881623
ko04217	Necroptosis	8/708	178/7206	0.0145424327498
ko03018	RNA degradation	2/708	84/7206	0.0153892486472
ko04930	Type II diabetes mellitus	11/708	54/7206	0.0180041891465
ko04973	Carbohydrate digestion and absorption	9/708	42/7206	0.0186851825686
ko04640	Hematopoietic cell lineage	1/708	64/7206	0.0187367461117
ko00512	Mucin type O-glycan biosynthesis	7/708	29/7206	0.0195657160923
ko04964	Proximal tubule bicarbonate reclamation	7/708	29/7206	0.0195657160923
ko04137	Mitophagy - animal	2/708	82/7206	0.0226986581306
ko01200	Carbon metabolism	5/708	128/7206	0.0230937071215
ko00240	Pyrimidine metabolism	4/708	110/7206	0.023165114974
ko04064	NF-kappa B signaling pathway	3/708	96/7206	0.023292219241
ko05169	Epstein-Barr virus infection	11/708	206/7206	0.0240408223814
ko05140	Leishmaniasis	2/708	75/7206	0.0309351590161
ko05323	Rheumatoid arthritis	15/708	89/7206	0.0312929576491
ko04612	Antigen processing and presentation	2/708	77/7206	0.0316130162278
ko04140	Autophagy - animal	8/708	164/7206	0.0324970640785
ko04630	Jak-STAT signaling pathway	6/708	132/7206	0.0380091189098
ko00480	Glutathione metabolism	1/708	55/7206	0.0396913251354
ko05321	Inflammatory bowel disease (IBD)	1/708	56/7206	0.039970375823
ko05410	Hypertrophic cardiomyopathy (HCM)	16/708	100/7206	0.042423918617
ko04961	Endocrine and other factor-regulated calcium reabsorption	11/708	59/7206	0.0431171612612
ko04350	TGF-beta signaling pathway	4/708	103/7206	0.0434449396715
ko04932	Non-alcoholic fatty liver disease (NAFLD)	10/708	182/7206	0.0437130684465
ko00310	Lysine degradation	2/708	73/7206	0.0448291927936
ko04110	Cell cycle	7/708	145/7206	0.0467261396746