ko pathway ratio_in_study ratio_in_pop p_value ko03040 Spliceosome 40/504 145/7206 1.30609253467e-14 ko05217 Basal cell carcinoma 27/504 68/7206 1.49338398429e-14 ko04550 Signaling pathways regulating pluripotency of stem cells 42/504 165/7206 5.9389583802e-14 ko04080 Neuroactive ligand-receptor interaction 4/504 423/7206 1.69927099366e-09 ko04330 Notch signaling pathway 20/504 62/7206 3.13405369502e-09 ko05224 Breast cancer 35/504 174/7206 7.96551138042e-09 ko04110 Cell cycle 31/504 145/7206 1.29765505051e-08 ko04310 Wnt signaling pathway 35/504 181/7206 2.31894549696e-08 ko04390 Hippo signaling pathway 34/504 188/7206 2.03590462616e-07 ko04111 Cell cycle - yeast 21/504 90/7206 6.51310061119e-07 ko04340 Hedgehog signaling pathway 16/504 58/7206 1.320389131e-06 ko05200 Pathways in cancer 63/504 492/7206 1.49278969145e-06 ko04360 Axon guidance 36/504 233/7206 5.17043518732e-06 ko03030 DNA replication 12/504 38/7206 6.06205058088e-06 ko04921 Oxytocin signaling pathway 1/504 209/7206 6.17609090458e-06 ko05010 Alzheimer's disease 1/504 202/7206 9.16831223243e-06 ko04950 Maturity onset diabetes of the young 10/504 29/7206 1.52500419081e-05 ko03015 mRNA surveillance pathway 19/504 93/7206 1.76237749657e-05 ko03410 Base excision repair 11/504 38/7206 3.72650962753e-05 ko05202 Transcriptional misregulation in cancer 29/504 188/7206 5.5462022528e-05 ko04020 Calcium signaling pathway 4/504 265/7206 6.31419792721e-05 ko04350 TGF-beta signaling pathway 18/504 103/7206 0.000244224004186 ko03013 RNA transport 25/504 166/7206 0.000270227614316 ko03008 Ribosome biogenesis in eukaryotes 15/504 79/7206 0.000314681134219 ko04270 Vascular smooth muscle contraction 1/504 154/7206 0.000316641952431 ko04932 Non-alcoholic fatty liver disease (NAFLD) 2/504 182/7206 0.00032143364416 ko04141 Protein processing in endoplasmic reticulum 2/504 184/7206 0.000329826026812 ko05205 Proteoglycans in cancer 35/504 271/7206 0.00036028566013 ko04144 Endocytosis 9/504 342/7206 0.000454159504112 ko04723 Retrograde endocannabinoid signaling 2/504 175/7206 0.000462864124727 ko04072 Phospholipase D signaling pathway 3/504 197/7206 0.000593297730985 ko05166 HTLV-I infection 36/504 292/7206 0.000894258827525 ko04022 cGMP-PKG signaling pathway 4/504 216/7206 0.000982923424519 ko04726 Serotonergic synapse 1/504 137/7206 0.00100618719082 ko05222 Small cell lung cancer 15/504 89/7206 0.00116476803246 ko04621 NOD-like receptor signaling pathway 2/504 157/7206 0.00138792975392 ko05206 MicroRNAs in cancer 24/504 177/7206 0.00149527147777 ko04919 Thyroid hormone signaling pathway 20/504 143/7206 0.00248115130988 ko04062 Chemokine signaling pathway 4/504 201/7206 0.00277881872771 ko04113 Meiosis - yeast 12/504 70/7206 0.00305310638707 ko04070 Phosphatidylinositol signaling system 1/504 112/7206 0.00452894206467 ko04972 Pancreatic secretion 1/504 111/7206 0.00453228569186 ko04725 Cholinergic synapse 3/504 160/7206 0.00681620844003 ko04727 GABAergic synapse 1/504 110/7206 0.00692657608692 ko04916 Melanogenesis 18/504 142/7206 0.011963387281 ko04970 Salivary secretion 1/504 95/7206 0.0139928762076 ko04260 Cardiac muscle contraction 1/504 98/7206 0.0144812679492 ko04971 Gastric acid secretion 1/504 98/7206 0.0144812679492 ko04071 Sphingolipid signaling pathway 4/504 162/7206 0.0183650484892 ko04920 Adipocytokine signaling pathway 1/504 89/7206 0.0202914429594 ko05414 Dilated cardiomyopathy 2/504 112/7206 0.0236500267192 ko04217 Necroptosis 5/504 178/7206 0.0243597982181 ko04713 Circadian entrainment 3/504 136/7206 0.0253741598359 ko01230 Biosynthesis of amino acids 1/504 85/7206 0.0297465603796 ko00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin 5/504 26/7206 0.031710287846 ko04910 Insulin signaling pathway 5/504 172/7206 0.0326568300592 ko04925 Aldosterone synthesis and secretion 2/504 105/7206 0.0331749287515 ko04391 Hippo signaling pathway - fly 12/504 90/7206 0.0332134407506 ko04915 Estrogen signaling pathway 3/504 131/7206 0.0353975713496 ko04261 Adrenergic signaling in cardiomyocytes 7/504 205/7206 0.037126307566 ko03420 Nucleotide excision repair 7/504 46/7206 0.0390249488011 ko04139 Mitophagy - yeast 6/504 37/7206 0.0414196765782 ko04923 Regulation of lipolysis in adipocytes 1/504 77/7206 0.0424430930847 ko04730 Long-term depression 1/504 78/7206 0.0425677490562 ko04610 Complement and coagulation cascades 1/504 79/7206 0.042890854962 ko04611 Platelet activation 5/504 163/7206 0.043157439617 ko04976 Bile secretion 1/504 80/7206 0.0434115209721 ko04137 Mitophagy - animal 1/504 82/7206 0.045042814427 ko04341 Hedgehog signaling pathway - fly 6/504 38/7206 0.0464016903753 ko04720 Long-term potentiation 2/504 99/7206 0.0465318298758 ko00564 Glycerophospholipid metabolism 2/504 99/7206 0.0465318298758 ko05410 Hypertrophic cardiomyopathy (HCM) 2/504 100/7206 0.0466594656031 ko04912 GnRH signaling pathway 3/504 122/7206 0.0472189923377