ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 38/524 191/7206 7.31109323031e-09 ko04380 Osteoclast differentiation 28/524 134/7206 2.5217262849e-07 ko04650 Natural killer cell mediated cytotoxicity 21/524 97/7206 4.4772896817e-06 ko04672 Intestinal immune network for IgA production 11/524 37/7206 4.05639721129e-05 ko04070 Phosphatidylinositol signaling system 20/524 112/7206 0.000140004002485 ko05321 Inflammatory bowel disease (IBD) 13/524 56/7206 0.000141460724556 ko04658 Th1 and Th2 cell differentiation 18/524 96/7206 0.000158004817491 ko04710 Circadian rhythm 11/524 43/7206 0.000182861950532 ko04659 Th17 cell differentiation 19/524 106/7206 0.000194290650085 ko04660 T cell receptor signaling pathway 21/524 124/7206 0.000287770291458 ko03040 Spliceosome 1/524 145/7206 0.000486463033791 ko05152 Tuberculosis 27/524 187/7206 0.000506149217082 ko03013 RNA transport 2/524 166/7206 0.00068122841901 ko03010 Ribosome 1/524 129/7206 0.000974633599041 ko04020 Calcium signaling pathway 34/524 265/7206 0.00101112931654 ko05340 Primary immunodeficiency 8/524 30/7206 0.00103556822825 ko05162 Measles 19/524 120/7206 0.00108246832212 ko04664 Fc epsilon RI signaling pathway 14/524 77/7206 0.00114308055126 ko05164 Influenza A 24/524 167/7206 0.00123856050419 ko04662 B cell receptor signaling pathway 15/524 88/7206 0.00153061226422 ko04611 Platelet activation 23/524 163/7206 0.00192008393388 ko00140 Steroid hormone biosynthesis 9/524 41/7206 0.00226944297808 ko00120 Primary bile acid biosynthesis 6/524 20/7206 0.00230707977094 ko05145 Toxoplasmosis 19/524 126/7206 0.00251610265654 ko05140 Leishmaniasis 13/524 75/7206 0.00265205959177 ko00051 Fructose and mannose metabolism 9/524 42/7206 0.00270653957391 ko04022 cGMP-PKG signaling pathway 28/524 216/7206 0.00299528725859 ko04072 Phospholipase D signaling pathway 26/524 197/7206 0.00302339580538 ko00590 Arachidonic acid metabolism 10/524 52/7206 0.0037167230658 ko00562 Inositol phosphate metabolism 14/524 89/7206 0.00580436628565 ko04921 Oxytocin signaling pathway 26/524 209/7206 0.00636632543964 ko04610 Complement and coagulation cascades 13/524 79/7206 0.00671885033513 ko05167 Kaposi's sarcoma-associated herpesvirus infection 24/524 191/7206 0.0070589447899 ko05034 Alcoholism 7/524 238/7206 0.0070730949888 ko04621 NOD-like receptor signaling pathway 21/524 157/7206 0.00720954771138 ko05230 Central carbon metabolism in cancer 13/524 81/7206 0.00740513684222 ko04750 Inflammatory mediator regulation of TRP channels 17/524 122/7206 0.00784228335461 ko04666 Fc gamma R-mediated phagocytosis 17/524 122/7206 0.00784228335461 ko04725 Cholinergic synapse 21/524 160/7206 0.00792482245844 ko04630 Jak-STAT signaling pathway 18/524 132/7206 0.00972740903634 ko00592 alpha-Linolenic acid metabolism 5/524 19/7206 0.00986136621665 ko04933 AGE-RAGE signaling pathway in diabetic complications 18/524 135/7206 0.0110159360126 ko04137 Mitophagy - animal 12/524 82/7206 0.0167735582301 ko05160 Hepatitis C 19/524 153/7206 0.0180436465597 ko05322 Systemic lupus erythematosus 4/524 151/7206 0.0250490028816 ko04015 Rap1 signaling pathway 30/524 278/7206 0.0251729710193 ko05231 Choline metabolism in cancer 17/524 134/7206 0.0266427757291 ko05330 Allograft rejection 5/524 24/7206 0.026703722327 ko04960 Aldosterone-regulated sodium reabsorption 7/524 41/7206 0.0267050792938 ko04062 Chemokine signaling pathway 23/524 201/7206 0.0268579707749 ko04730 Long-term depression 11/524 78/7206 0.0273517081192 ko05166 HTLV-I infection 31/524 292/7206 0.0287518172896 ko04726 Serotonergic synapse 17/524 137/7206 0.0288278596527 ko05310 Asthma 4/524 17/7206 0.0307554640544 ko04014 Ras signaling pathway 30/524 279/7206 0.0331340938834 ko04110 Cell cycle 4/524 145/7206 0.0339431968417 ko05150 Staphylococcus aureus infection 6/524 36/7206 0.043267700328 ko04120 Ubiquitin mediated proteolysis 4/524 138/7206 0.0455363685314 ko04919 Thyroid hormone signaling pathway 17/524 143/7206 0.0481515967309 ko04640 Hematopoietic cell lineage 9/524 64/7206 0.0484394736706