ko pathway ratio_in_study ratio_in_pop p_value ko03040 Spliceosome 73/347 145/7206 5.01582734708e-59 ko03030 DNA replication 22/347 38/7206 5.97411071071e-20 ko03013 RNA transport 40/347 166/7206 4.48877581694e-18 ko03430 Mismatch repair 14/347 22/7206 6.2860244671e-14 ko00240 Pyrimidine metabolism 27/347 110/7206 9.56805868945e-13 ko04111 Cell cycle - yeast 24/347 90/7206 2.64469060214e-12 ko04110 Cell cycle 28/347 145/7206 1.7178528209e-10 ko03420 Nucleotide excision repair 15/347 46/7206 1.68431720663e-09 ko03008 Ribosome biogenesis in eukaryotes 19/347 79/7206 3.57735163259e-09 ko03410 Base excision repair 13/347 38/7206 1.08609337602e-08 ko03015 mRNA surveillance pathway 20/347 93/7206 1.10410154904e-08 ko04113 Meiosis - yeast 17/347 70/7206 2.07418134937e-08 ko03440 Homologous recombination 11/347 41/7206 2.36637307791e-06 ko03020 RNA polymerase 9/347 29/7206 5.33618268492e-06 ko00230 Purine metabolism 25/347 194/7206 5.66177685993e-06 ko03018 RNA degradation 15/347 84/7206 9.1294594033e-06 ko04144 Endocytosis 2/347 342/7206 1.20478017522e-05 ko03022 Basal transcription factors 10/347 44/7206 3.36836094567e-05 ko03460 Fanconi anemia pathway 10/347 51/7206 0.00012835222512 ko05168 Herpes simplex infection 21/347 182/7206 0.000163182571537 ko04022 cGMP-PKG signaling pathway 1/347 216/7206 0.000513054502934 ko04024 cAMP signaling pathway 3/347 279/7206 0.000897233085437 ko04072 Phospholipase D signaling pathway 1/347 197/7206 0.0010751834014 ko05010 Alzheimer's disease 1/347 202/7206 0.00114735250244 ko05152 Tuberculosis 1/347 187/7206 0.00156362068975 ko04060 Cytokine-cytokine receptor interaction 1/347 191/7206 0.00160427621765 ko05166 HTLV-I infection 26/347 292/7206 0.002003314129 ko04151 PI3K-Akt signaling pathway 7/347 390/7206 0.00217040548215 ko05169 Epstein-Barr virus infection 20/347 206/7206 0.00248842420641 ko04120 Ubiquitin mediated proteolysis 15/347 138/7206 0.00355241690937 ko04261 Adrenergic signaling in cardiomyocytes 2/347 205/7206 0.00435852635439 ko04921 Oxytocin signaling pathway 2/347 209/7206 0.00450340062311 ko04270 Vascular smooth muscle contraction 1/347 154/7206 0.0070426284113 ko05012 Parkinson's disease 1/347 155/7206 0.00705954110192 ko04621 NOD-like receptor signaling pathway 1/347 157/7206 0.00714913067183 ko04360 Axon guidance 3/347 233/7206 0.00722768156949 ko04810 Regulation of actin cytoskeleton 4/347 264/7206 0.00756328169516 ko04142 Lysosome 1/347 151/7206 0.010646473969 ko04724 Glutamatergic synapse 1/347 152/7206 0.0108112689248 ko04015 Rap1 signaling pathway 5/347 278/7206 0.0140662470116 ko04014 Ras signaling pathway 5/347 279/7206 0.0141749655901 ko04723 Retrograde endocannabinoid signaling 2/347 175/7206 0.0180980827659 ko04510 Focal adhesion 4/347 240/7206 0.0197680854704 ko05203 Viral carcinogenesis 22/347 277/7206 0.0206825831882 ko01200 Carbon metabolism 1/347 128/7206 0.0213728378813 ko04540 Gap junction 1/347 128/7206 0.0213728378813 ko05142 Chagas disease (American trypanosomiasis) 1/347 130/7206 0.0214239235161 ko04915 Estrogen signaling pathway 1/347 131/7206 0.021525214645 ko04010 MAPK signaling pathway 7/347 321/7206 0.0223361448204 ko04713 Circadian entrainment 1/347 136/7206 0.0227925948995 ko04152 AMPK signaling pathway 2/347 161/7206 0.0246825981612 ko04725 Cholinergic synapse 2/347 160/7206 0.0246900689794 ko04145 Phagosome 2/347 162/7206 0.0247203586703 ko04530 Tight junction 4/347 228/7206 0.0261615049803 ko04668 TNF signaling pathway 1/347 120/7206 0.0308075803701 ko05145 Toxoplasmosis 1/347 126/7206 0.0320275516094 ko04914 Progesterone-mediated oocyte maturation 10/347 104/7206 0.0332957107218 ko04728 Dopaminergic synapse 3/347 185/7206 0.0356510472166 ko04371 Apelin signaling pathway 3/347 177/7206 0.0488892636507