ko pathway ratio_in_study ratio_in_pop p_value ko04727 GABAergic synapse 30/373 110/7206 1.57775268364e-14 ko05032 Morphine addiction 25/373 110/7206 2.02389650635e-10 ko04728 Dopaminergic synapse 33/373 185/7206 2.45313804038e-10 ko05033 Nicotine addiction 17/373 56/7206 1.46603118418e-09 ko04724 Glutamatergic synapse 27/373 152/7206 1.23936415784e-08 ko04723 Retrograde endocannabinoid signaling 28/373 175/7206 6.99690962152e-08 ko04744 Phototransduction 12/373 36/7206 1.25509124318e-07 ko04725 Cholinergic synapse 26/373 160/7206 1.51817490842e-07 ko04742 Taste transduction 15/373 61/7206 3.07593943115e-07 ko04713 Circadian entrainment 23/373 136/7206 3.87191995988e-07 ko04080 Neuroactive ligand-receptor interaction 46/373 423/7206 1.17422056662e-06 ko04721 Synaptic vesicle cycle 16/373 80/7206 2.47077838052e-06 ko04726 Serotonergic synapse 21/373 137/7206 6.37779927917e-06 ko04974 Protein digestion and absorption 17/373 96/7206 6.90064185071e-06 ko04911 Insulin secretion 19/373 117/7206 7.50032950225e-06 ko04260 Cardiac muscle contraction 15/373 98/7206 0.000137544617998 ko04740 Olfactory transduction 13/373 80/7206 0.000207141868309 ko05030 Cocaine addiction 12/373 73/7206 0.000323849022285 ko04261 Adrenergic signaling in cardiomyocytes 23/373 205/7206 0.000553179102116 ko04151 PI3K-Akt signaling pathway 36/373 390/7206 0.000583446753205 ko04512 ECM-receptor interaction 12/373 79/7206 0.000681529530835 ko05031 Amphetamine addiction 13/373 91/7206 0.000752068834927 ko04961 Endocrine and other factor-regulated calcium reabsorption 10/373 59/7206 0.000789118390323 ko05014 Amyotrophic lateral sclerosis (ALS) 11/373 74/7206 0.00135807209655 ko04550 Signaling pathways regulating pluripotency of stem cells 18/373 165/7206 0.00224201533784 ko05164 Influenza A 1/373 167/7206 0.00226382940536 ko04950 Maturity onset diabetes of the young 6/373 29/7206 0.00317982042956 ko00430 Taurine and hypotaurine metabolism 4/373 14/7206 0.00467211766001 ko04120 Ubiquitin mediated proteolysis 1/373 138/7206 0.0102500901461 ko05167 Kaposi's sarcoma-associated herpesvirus infection 18/373 191/7206 0.0121399303909 ko03013 RNA transport 2/373 166/7206 0.0123435466743 ko04024 cAMP signaling pathway 24/373 279/7206 0.0126110904947 ko04010 MAPK signaling pathway 27/373 321/7206 0.0133907474173 ko04964 Proximal tubule bicarbonate reclamation 5/373 29/7206 0.0153693052647 ko04978 Mineral absorption 6/373 40/7206 0.0159319805051 ko04611 Platelet activation 2/373 163/7206 0.0180212598753 ko04066 HIF-1 signaling pathway 1/373 123/7206 0.0215542537092 ko04150 mTOR signaling pathway 3/373 184/7206 0.026359799346 ko04145 Phagosome 15/373 162/7206 0.0286397758772 ko04970 Salivary secretion 10/373 95/7206 0.0306998660616 ko03040 Spliceosome 2/373 145/7206 0.0348458228268 ko05034 Alcoholism 20/373 238/7206 0.0351690871321 ko04976 Bile secretion 9/373 80/7206 0.0356854163513 ko02024 Quorum sensing 3/373 15/7206 0.0393571222161 ko04924 Renin secretion 9/373 86/7206 0.0430947495484 ko04918 Thyroid hormone synthesis 9/373 86/7206 0.0430947495484 ko04914 Progesterone-mediated oocyte maturation 1/373 104/7206 0.0440379585972 ko01521 EGFR tyrosine kinase inhibitor resistance 1/373 106/7206 0.0442924305288 ko00250 Alanine, aspartate and glutamate metabolism 5/373 38/7206 0.0445658825491 ko04140 Autophagy - animal 3/373 164/7206 0.0485702695304 ko05205 Proteoglycans in cancer 7/373 271/7206 0.0495011320546