ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 132/807 423/7206 8.06623784277e-31 ko05033 Nicotine addiction 42/807 56/7206 5.49207757978e-29 ko04724 Glutamatergic synapse 70/807 152/7206 5.87734294533e-28 ko04727 GABAergic synapse 49/807 110/7206 4.3173334111e-19 ko05032 Morphine addiction 49/807 110/7206 4.3173334111e-19 ko04728 Dopaminergic synapse 66/807 185/7206 5.13176102237e-19 ko04721 Synaptic vesicle cycle 41/807 80/7206 5.86705932211e-19 ko04713 Circadian entrainment 53/807 136/7206 2.06762298592e-17 ko04723 Retrograde endocannabinoid signaling 60/807 175/7206 1.96499942687e-16 ko04725 Cholinergic synapse 54/807 160/7206 1.43355374489e-14 ko04024 cAMP signaling pathway 69/807 279/7206 8.59523517279e-11 ko04911 Insulin secretion 38/807 117/7206 4.5764163286e-10 ko05031 Amphetamine addiction 31/807 91/7206 5.13764204362e-09 ko04726 Serotonergic synapse 40/807 137/7206 5.42937118456e-09 ko04921 Oxytocin signaling pathway 51/807 209/7206 4.16744929172e-08 ko04261 Adrenergic signaling in cardiomyocytes 50/807 205/7206 5.8659965819e-08 ko05030 Cocaine addiction 25/807 73/7206 1.40696615826e-07 ko04720 Long-term potentiation 30/807 99/7206 1.82829072056e-07 ko04742 Taste transduction 22/807 61/7206 2.81969924563e-07 ko04020 Calcium signaling pathway 58/807 265/7206 4.20287952291e-07 ko04744 Phototransduction 16/807 36/7206 4.42963106068e-07 ko05014 Amyotrophic lateral sclerosis (ALS) 24/807 74/7206 7.85922287033e-07 ko03040 Spliceosome 1/807 145/7206 8.47557108315e-07 ko04970 Salivary secretion 28/807 95/7206 8.81117209956e-07 ko04514 Cell adhesion molecules (CAMs) 34/807 130/7206 1.51738170601e-06 ko04010 MAPK signaling pathway 64/807 321/7206 2.92190093284e-06 ko04060 Cytokine-cytokine receptor interaction 4/807 191/7206 3.62377934931e-06 ko05203 Viral carcinogenesis 10/807 277/7206 6.04155235572e-06 ko05168 Herpes simplex infection 4/807 182/7206 7.4788523315e-06 ko05164 Influenza A 3/807 167/7206 8.49621112178e-06 ko04966 Collecting duct acid secretion 11/807 26/7206 5.12407202401e-05 ko04730 Long-term depression 21/807 78/7206 8.9607368656e-05 ko04621 NOD-like receptor signaling pathway 4/807 157/7206 9.60985746901e-05 ko03013 RNA transport 5/807 166/7206 0.000159992701752 ko04072 Phospholipase D signaling pathway 40/807 197/7206 0.000199958798186 ko04972 Pancreatic secretion 26/807 111/7206 0.000200072843971 ko00604 Glycosphingolipid biosynthesis - ganglio series 7/807 14/7206 0.000363387459679 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 20/807 79/7206 0.000403197193574 ko04360 Axon guidance 44/807 233/7206 0.000433941019748 ko04925 Aldosterone synthesis and secretion 24/807 105/7206 0.000501443186232 ko04141 Protein processing in endoplasmic reticulum 7/807 184/7206 0.000510077997973 ko05322 Systemic lupus erythematosus 5/807 151/7206 0.000627941784617 ko04014 Ras signaling pathway 50/807 279/7206 0.000643506234164 ko04915 Estrogen signaling pathway 28/807 131/7206 0.000648363093629 ko05169 Epstein-Barr virus infection 9/807 206/7206 0.000698938445771 ko05205 Proteoglycans in cancer 14/807 271/7206 0.000762385839025 ko04540 Gap junction 27/807 128/7206 0.000976854569647 ko04260 Cardiac muscle contraction 22/807 98/7206 0.00110364299504 ko04971 Gastric acid secretion 22/807 98/7206 0.00110364299504 ko04070 Phosphatidylinositol signaling system 24/807 112/7206 0.00137593295892 ko04612 Antigen processing and presentation 1/807 77/7206 0.00173732500817 ko05110 Vibrio cholerae infection 16/807 63/7206 0.00174962728113 ko03008 Ribosome biogenesis in eukaryotes 1/807 79/7206 0.00178103400391 ko04022 cGMP-PKG signaling pathway 39/807 216/7206 0.00208527356342 ko04120 Ubiquitin mediated proteolysis 5/807 138/7206 0.00240020641572 ko05162 Measles 4/807 120/7206 0.00314023802763 ko04214 Apoptosis - fly 1/807 72/7206 0.00391867428216 ko04350 TGF-beta signaling pathway 3/807 103/7206 0.004061839374 ko00310 Lysine degradation 1/807 73/7206 0.00407567021838 ko04932 Non-alcoholic fatty liver disease (NAFLD) 9/807 182/7206 0.00413214385867 ko05166 HTLV-I infection 18/807 292/7206 0.00426967163948 ko04745 Phototransduction - fly 10/807 38/7206 0.00744395705887 ko04064 NF-kappa B signaling pathway 3/807 96/7206 0.00817790857669 ko04640 Hematopoietic cell lineage 1/807 64/7206 0.00835861710137 ko00240 Pyrimidine metabolism 4/807 110/7206 0.00867318498381 ko05414 Dilated cardiomyopathy 22/807 112/7206 0.00919249079533 ko04740 Olfactory transduction 17/807 80/7206 0.0109116512603 ko04110 Cell cycle 7/807 145/7206 0.0109432189096 ko05231 Choline metabolism in cancer 25/807 134/7206 0.0118440800788 ko00512 Mucin type O-glycan biosynthesis 8/807 29/7206 0.0120044737169 ko05140 Leishmaniasis 2/807 75/7206 0.0149986974251 ko04140 Autophagy - animal 9/807 164/7206 0.0166996350143 ko00480 Glutathione metabolism 1/807 55/7206 0.0178818573588 ko05161 Hepatitis B 10/807 173/7206 0.0198689622798 ko00533 Glycosaminoglycan biosynthesis - keratan sulfate 5/807 15/7206 0.020025042839 ko05145 Toxoplasmosis 6/807 126/7206 0.021250327335 ko05034 Alcoholism 38/807 238/7206 0.0213273026478 ko03018 RNA degradation 3/807 84/7206 0.0223018737485 ko04924 Renin secretion 17/807 86/7206 0.0231958418567 ko00590 Arachidonic acid metabolism 1/807 52/7206 0.0261859763999 ko04217 Necroptosis 11/807 178/7206 0.0297979370812 ko04961 Endocrine and other factor-regulated calcium reabsorption 12/807 59/7206 0.0356572154786 ko05410 Hypertrophic cardiomyopathy (HCM) 18/807 100/7206 0.0370675969097 ko04964 Proximal tubule bicarbonate reclamation 7/807 29/7206 0.037138585096 ko04510 Focal adhesion 17/807 240/7206 0.0373508258381 ko04015 Rap1 signaling pathway 42/807 278/7206 0.0411855859419 ko04146 Peroxisome 4/807 89/7206 0.0415868872411 ko05222 Small cell lung cancer 4/807 89/7206 0.0415868872411 ko01524 Platinum drug resistance 3/807 76/7206 0.042906262611 ko04626 Plant-pathogen interaction 5/807 18/7206 0.0431082129111 ko05120 Epithelial cell signaling in Helicobacter pylori infection 17/807 92/7206 0.0432914015669 ko04976 Bile secretion 15/807 80/7206 0.0468148204468 ko04930 Type II diabetes mellitus 11/807 54/7206 0.0469814528398 ko05215 Prostate cancer 6/807 111/7206 0.0486568532213