ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 28/332 191/7206 3.95902457143e-08 ko00140 Steroid hormone biosynthesis 12/332 41/7206 1.77223365295e-07 ko04621 NOD-like receptor signaling pathway 23/332 157/7206 6.84861409557e-07 ko00643 Styrene degradation 4/332 4/7206 4.42853981367e-06 ko04974 Protein digestion and absorption 16/332 96/7206 6.58459664516e-06 ko05164 Influenza A 22/332 167/7206 7.25135385666e-06 ko04380 Osteoclast differentiation 19/332 134/7206 1.05990465462e-05 ko00350 Tyrosine metabolism 9/332 33/7206 1.21271790057e-05 ko04064 NF-kappa B signaling pathway 15/332 96/7206 2.84721702464e-05 ko05145 Toxoplasmosis 17/332 126/7206 5.92663035938e-05 ko00360 Phenylalanine metabolism 6/332 17/7206 7.34573390319e-05 ko04622 RIG-I-like receptor signaling pathway 11/332 62/7206 0.000103397891824 ko04657 IL-17 signaling pathway 13/332 87/7206 0.000155200545703 ko00120 Primary bile acid biosynthesis 6/332 20/7206 0.00020452478985 ko05160 Hepatitis C 18/332 153/7206 0.000218034852579 ko05204 Chemical carcinogenesis 9/332 48/7206 0.000286066070888 ko04668 TNF signaling pathway 15/332 120/7206 0.0003770163368 ko05034 Alcoholism 2/332 238/7206 0.00149279273011 ko05133 Pertussis 11/332 87/7206 0.00203810018874 ko04620 Toll-like receptor signaling pathway 12/332 100/7206 0.00203940933781 ko00980 Metabolism of xenobiotics by cytochrome P450 7/332 40/7206 0.0020708353919 ko00100 Steroid biosynthesis 5/332 21/7206 0.00222494814773 ko04662 B cell receptor signaling pathway 11/332 88/7206 0.0022358323354 ko04623 Cytosolic DNA-sensing pathway 7/332 41/7206 0.00240054691947 ko05142 Chagas disease (American trypanosomiasis) 14/332 130/7206 0.00253046348569 ko00983 Drug metabolism - other enzymes 7/332 42/7206 0.00276926110862 ko05131 Shigellosis 10/332 82/7206 0.00419677490829 ko00040 Pentose and glucuronate interconversions 5/332 26/7206 0.0059535587586 ko04672 Intestinal immune network for IgA production 6/332 37/7206 0.0063349949153 ko00982 Drug metabolism - cytochrome P450 6/332 37/7206 0.0063349949153 ko04660 T cell receptor signaling pathway 13/332 124/7206 0.00723320884777 ko03013 RNA transport 1/332 166/7206 0.00733090199541 ko05222 Small cell lung cancer 10/332 89/7206 0.0075139197466 ko05161 Hepatitis B 16/332 173/7206 0.00843280569816 ko00920 Sulfur metabolism 3/332 10/7206 0.00913127919329 ko04610 Complement and coagulation cascades 9/332 79/7206 0.0100518399012 ko04512 ECM-receptor interaction 9/332 79/7206 0.0100518399012 ko04931 Insulin resistance 13/332 137/7206 0.0117265143121 ko00830 Retinol metabolism 6/332 42/7206 0.0117935220379 ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis 2/332 4/7206 0.0119372035907 ko00130 Ubiquinone and other terpenoid-quinone biosynthesis 3/332 11/7206 0.0121323665005 ko04658 Th1 and Th2 cell differentiation 10/332 96/7206 0.0125668738644 ko04110 Cell cycle 1/332 145/7206 0.0149132983254 ko00053 Ascorbate and aldarate metabolism 4/332 22/7206 0.0167568411785 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 2/332 5/7206 0.0192924395974 ko00281 Geraniol degradation 2/332 5/7206 0.0192924395974 ko04630 Jak-STAT signaling pathway 12/332 132/7206 0.0201525966276 ko05140 Leishmaniasis 8/332 75/7206 0.0214229962542 ko04713 Circadian entrainment 1/332 136/7206 0.0215201717581 ko04611 Platelet activation 14/332 163/7206 0.0216936537594 ko04120 Ubiquitin mediated proteolysis 1/332 138/7206 0.021770595573 ko00260 Glycine, serine and threonine metabolism 6/332 48/7206 0.0219314374295 ko04114 Oocyte meiosis 1/332 139/7206 0.0219654126929 ko05150 Staphylococcus aureus infection 5/332 36/7206 0.0234635634761 ko05162 Measles 11/332 120/7206 0.0253886072742 ko04723 Retrograde endocannabinoid signaling 2/332 175/7206 0.0257988041102 ko00380 Tryptophan metabolism 6/332 50/7206 0.0263169082274 ko00362 Benzoate degradation 2/332 6/7206 0.0280651493952 ko05168 Herpes simplex infection 15/332 182/7206 0.0288831529805 ko04659 Th17 cell differentiation 10/332 106/7206 0.0302389429223 ko04540 Gap junction 1/332 128/7206 0.0311228774484 ko04933 AGE-RAGE signaling pathway in diabetic complications 12/332 135/7206 0.0337976859753 ko04972 Pancreatic secretion 10/332 111/7206 0.0365697002782 ko05215 Prostate cancer 10/332 111/7206 0.0365697002782 ko04080 Neuroactive ligand-receptor interaction 11/332 423/7206 0.041577322123 ko00051 Fructose and mannose metabolism 5/332 42/7206 0.0423950078967 ko05321 Inflammatory bowel disease (IBD) 6/332 56/7206 0.0428322999295 ko05132 Salmonella infection 9/332 98/7206 0.0456185389167 ko00966 Glucosinolate biosynthesis 1/332 1/7206 0.0460727171803 ko00401 Novobiocin biosynthesis 1/332 1/7206 0.0460727171803 ko04210 Apoptosis 14/332 180/7206 0.0469342071556 ko05340 Primary immunodeficiency 4/332 30/7206 0.0471400102094 ko05016 Huntington's disease 4/332 215/7206 0.047203983471 ko04724 Glutamatergic synapse 2/332 152/7206 0.0486710574713 ko00740 Riboflavin metabolism 2/332 8/7206 0.0492915904253