ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	196/1195	423/7206	9.12570586098e-50
ko04724	Glutamatergic synapse	89/1195	152/7206	2.22946081381e-32
ko05032	Morphine addiction	70/1195	110/7206	7.90825181083e-29
ko05033	Nicotine addiction	46/1195	56/7206	3.94277501582e-27
ko04727	GABAergic synapse	66/1195	110/7206	4.28293816011e-25
ko04713	Circadian entrainment	74/1195	136/7206	2.56923500237e-24
ko04725	Cholinergic synapse	79/1195	160/7206	2.61566609566e-22
ko04728	Dopaminergic synapse	85/1195	185/7206	2.78585031651e-21
ko04721	Synaptic vesicle cycle	50/1195	80/7206	2.13285326488e-20
ko04723	Retrograde endocannabinoid signaling	80/1195	175/7206	6.43663736546e-20
ko04024	cAMP signaling pathway	107/1195	279/7206	5.00253104229e-19
ko04020	Calcium signaling pathway	97/1195	265/7206	1.02468918788e-15
ko04911	Insulin secretion	56/1195	117/7206	2.22898044473e-15
ko04742	Taste transduction	37/1195	61/7206	8.2065513635e-15
ko04726	Serotonergic synapse	61/1195	137/7206	8.52727049538e-15
ko04921	Oxytocin signaling pathway	79/1195	209/7206	7.88691769466e-14
ko04261	Adrenergic signaling in cardiomyocytes	72/1195	205/7206	5.41994454582e-11
ko05031	Amphetamine addiction	40/1195	91/7206	6.11307559318e-10
ko04720	Long-term potentiation	42/1195	99/7206	8.71968951606e-10
ko04744	Phototransduction	22/1195	36/7206	2.04600822392e-09
ko03010	Ribosome	1/1195	129/7206	2.50411618651e-09
ko03040	Spliceosome	2/1195	145/7206	2.52158659223e-09
ko04925	Aldosterone synthesis and secretion	41/1195	105/7206	3.00580779913e-08
ko04970	Salivary secretion	38/1195	95/7206	3.8506533698e-08
ko04360	Axon guidance	70/1195	233/7206	2.17100888111e-07
ko03013	RNA transport	6/1195	166/7206	2.31445783512e-07
ko04971	Gastric acid secretion	37/1195	98/7206	3.5107107377e-07
ko05322	Systemic lupus erythematosus	5/1195	151/7206	3.82526741425e-07
ko04070	Phosphatidylinositol signaling system	39/1195	112/7206	2.14872154451e-06
ko05168	Herpes simplex infection	9/1195	182/7206	2.35422047353e-06
ko04022	cGMP-PKG signaling pathway	63/1195	216/7206	2.60146186991e-06
ko04010	MAPK signaling pathway	85/1195	321/7206	4.88247658313e-06
ko04514	Cell adhesion molecules (CAMs)	42/1195	130/7206	7.63831064218e-06
ko05030	Cocaine addiction	28/1195	73/7206	7.92792358443e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1195	74/7206	9.89485889045e-06
ko04072	Phospholipase D signaling pathway	57/1195	197/7206	1.010694229e-05
ko04014	Ras signaling pathway	75/1195	279/7206	1.11804581166e-05
ko04972	Pancreatic secretion	37/1195	111/7206	1.36902722553e-05
ko04621	NOD-like receptor signaling pathway	8/1195	157/7206	1.74243724986e-05
ko04060	Cytokine-cytokine receptor interaction	12/1195	191/7206	2.78988265115e-05
ko05203	Viral carcinogenesis	22/1195	277/7206	3.26016531133e-05
ko04730	Long-term depression	28/1195	78/7206	3.78724248468e-05
ko05164	Influenza A	10/1195	167/7206	5.23016211576e-05
ko04750	Inflammatory mediator regulation of TRP channels	38/1195	122/7206	6.27755342945e-05
ko04141	Protein processing in endoplasmic reticulum	12/1195	184/7206	7.40522120617e-05
ko04966	Collecting duct acid secretion	13/1195	26/7206	8.31024175564e-05
ko04745	Phototransduction - fly	16/1195	38/7206	0.000171622361404
ko04540	Gap junction	38/1195	128/7206	0.000173754425707
ko03008	Ribosome biogenesis in eukaryotes	2/1195	79/7206	0.000177262650493
ko04915	Estrogen signaling pathway	39/1195	131/7206	0.000189432891879
ko04740	Olfactory transduction	27/1195	80/7206	0.000192985706535
ko04110	Cell cycle	9/1195	145/7206	0.000264691373006
ko04710	Circadian rhythm	17/1195	43/7206	0.000270786803581
ko04961	Endocrine and other factor-regulated calcium reabsorption	21/1195	59/7206	0.000326854845888
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/1195	79/7206	0.000343428180846
ko04923	Regulation of lipolysis in adipocytes	25/1195	77/7206	0.000544417317856
ko04924	Renin secretion	27/1195	86/7206	0.000632930355751
ko05414	Dilated cardiomyopathy	33/1195	112/7206	0.000722829264031
ko05110	Vibrio cholerae infection	21/1195	63/7206	0.000975699623856
ko04612	Antigen processing and presentation	3/1195	77/7206	0.00101849823409
ko04626	Plant-pathogen interaction	9/1195	18/7206	0.00107203629016
ko04964	Proximal tubule bicarbonate reclamation	12/1195	29/7206	0.00133950850725
ko04371	Apelin signaling pathway	46/1195	177/7206	0.00138454601094
ko04976	Bile secretion	24/1195	80/7206	0.00232630925816
ko04260	Cardiac muscle contraction	28/1195	98/7206	0.00245330956619
ko04930	Type II diabetes mellitus	18/1195	54/7206	0.00255666460677
ko00330	Arginine and proline metabolism	2/1195	61/7206	0.00268651797586
ko04270	Vascular smooth muscle contraction	40/1195	154/7206	0.00287863183177
ko04064	NF-kappa B signaling pathway	6/1195	96/7206	0.00355060772756
ko05144	Malaria	1/1195	45/7206	0.00436300806441
ko00071	Fatty acid degradation	1/1195	45/7206	0.00436300806441
ko03420	Nucleotide excision repair	1/1195	46/7206	0.00442047873453
ko05231	Choline metabolism in cancer	35/1195	134/7206	0.00460015626186
ko04120	Ubiquitin mediated proteolysis	11/1195	138/7206	0.00515944881023
ko04973	Carbohydrate digestion and absorption	14/1195	42/7206	0.00640941122596
ko03022	Basal transcription factors	1/1195	44/7206	0.00677768609084
ko05140	Leishmaniasis	4/1195	75/7206	0.00706956721449
ko04916	Melanogenesis	36/1195	142/7206	0.00826953841034
ko00280	Valine, leucine and isoleucine degradation	2/1195	54/7206	0.00868803665761
ko04622	RIG-I-like receptor signaling pathway	3/1195	62/7206	0.00919602341629
ko04146	Peroxisome	6/1195	89/7206	0.00929762341212
ko04610	Complement and coagulation cascades	5/1195	79/7206	0.00953697925072
ko04015	Rap1 signaling pathway	62/1195	278/7206	0.0107515508862
ko00380	Tryptophan metabolism	2/1195	50/7206	0.0120219269591
ko05162	Measles	10/1195	120/7206	0.0127493543517
ko05161	Hepatitis B	17/1195	173/7206	0.0129551305127
ko04912	GnRH signaling pathway	31/1195	122/7206	0.0133387358699
ko00562	Inositol phosphate metabolism	24/1195	89/7206	0.0137380923593
ko00240	Pyrimidine metabolism	9/1195	110/7206	0.0138574038792
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1195	100/7206	0.0144913054555
ko03410	Base excision repair	1/1195	38/7206	0.0147598031306
ko03018	RNA degradation	6/1195	84/7206	0.0173672297667
ko00260	Glycine, serine and threonine metabolism	2/1195	48/7206	0.0176831431554
ko04960	Aldosterone-regulated sodium reabsorption	13/1195	41/7206	0.0177337626568
ko04115	p53 signaling pathway	5/1195	74/7206	0.0181461650028
ko04217	Necroptosis	18/1195	178/7206	0.0184619333681
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1195	14/7206	0.0185284768491
ko00500	Starch and sucrose metabolism	1/1195	35/7206	0.0220168570464
ko05169	Epstein-Barr virus infection	22/1195	206/7206	0.0220403654759
ko05131	Shigellosis	6/1195	82/7206	0.02380550885
ko04214	Apoptosis - fly	5/1195	72/7206	0.0249280038897
ko00310	Lysine degradation	5/1195	73/7206	0.0253186630089
ko04658	Th1 and Th2 cell differentiation	8/1195	96/7206	0.0266038374695
ko04213	Longevity regulating pathway - multiple species	22/1195	86/7206	0.0286694636418
ko04657	IL-17 signaling pathway	7/1195	87/7206	0.0291195717591
ko05133	Pertussis	7/1195	87/7206	0.0291195717591
ko05145	Toxoplasmosis	12/1195	126/7206	0.0294543640972
ko05205	Proteoglycans in cancer	32/1195	271/7206	0.0303194751402
ko04962	Vasopressin-regulated water reabsorption	16/1195	58/7206	0.0320032535329
ko04062	Chemokine signaling pathway	45/1195	201/7206	0.0336980140346
ko00640	Propanoate metabolism	1/1195	34/7206	0.0338838339026
ko03320	PPAR signaling pathway	5/1195	69/7206	0.0339775882779
ko03015	mRNA surveillance pathway	8/1195	93/7206	0.0351140760447
ko00590	Arachidonic acid metabolism	3/1195	52/7206	0.0374556307402
ko04071	Sphingolipid signaling pathway	37/1195	162/7206	0.0414880758069
ko05214	Glioma	20/1195	79/7206	0.0464921074984
ko05340	Primary immunodeficiency	1/1195	30/7206	0.0488387246476
ko04114	Oocyte meiosis	32/1195	139/7206	0.0493177757693