ko pathway ratio_in_study ratio_in_pop p_value ko04380 Osteoclast differentiation 26/404 134/7206 1.79264435413e-08 ko04621 NOD-like receptor signaling pathway 27/404 157/7206 1.34057755859e-07 ko04060 Cytokine-cytokine receptor interaction 29/404 191/7206 7.15994632423e-07 ko04658 Th1 and Th2 cell differentiation 19/404 96/7206 1.12950645418e-06 ko05164 Influenza A 26/404 167/7206 1.68146253922e-06 ko05340 Primary immunodeficiency 10/404 30/7206 2.99611171532e-06 ko04650 Natural killer cell mediated cytotoxicity 18/404 97/7206 5.69320258793e-06 ko00120 Primary bile acid biosynthesis 8/404 20/7206 6.31913172355e-06 ko00350 Tyrosine metabolism 10/404 33/7206 7.92846530027e-06 ko04620 Toll-like receptor signaling pathway 18/404 100/7206 8.89427152617e-06 ko05162 Measles 20/404 120/7206 9.54676620164e-06 ko04630 Jak-STAT signaling pathway 21/404 132/7206 1.20804336503e-05 ko05140 Leishmaniasis 15/404 75/7206 1.3444078145e-05 ko04064 NF-kappa B signaling pathway 17/404 96/7206 1.97480190375e-05 ko05145 Toxoplasmosis 20/404 126/7206 2.01659684851e-05 ko04672 Intestinal immune network for IgA production 10/404 37/7206 2.43693879517e-05 ko04660 T cell receptor signaling pathway 19/404 124/7206 5.36538563878e-05 ko00140 Steroid hormone biosynthesis 10/404 41/7206 6.40825130392e-05 ko04659 Th17 cell differentiation 17/404 106/7206 7.36828763435e-05 ko05168 Herpes simplex infection 24/404 182/7206 9.6203768491e-05 ko05150 Staphylococcus aureus infection 9/404 36/7206 0.000121515500398 ko04622 RIG-I-like receptor signaling pathway 12/404 62/7206 0.000137029883841 ko00360 Phenylalanine metabolism 6/404 17/7206 0.000218094606297 ko05321 Inflammatory bowel disease (IBD) 11/404 56/7206 0.000226310836 ko05034 Alcoholism 2/404 238/7206 0.000247237714474 ko05133 Pertussis 14/404 87/7206 0.000304647336545 ko04611 Platelet activation 21/404 163/7206 0.000355657590984 ko03320 PPAR signaling pathway 12/404 69/7206 0.000391595884619 ko04610 Complement and coagulation cascades 13/404 79/7206 0.00039729959797 ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis 3/404 4/7206 0.000670730073498 ko00643 Styrene degradation 3/404 4/7206 0.000670730073498 ko05152 Tuberculosis 22/404 187/7206 0.000951723852285 ko05160 Hepatitis C 19/404 153/7206 0.000994867805983 ko04662 B cell receptor signaling pathway 13/404 88/7206 0.00114238361241 ko05167 Kaposi's sarcoma-associated herpesvirus infection 22/404 191/7206 0.00115013129575 ko04146 Peroxisome 13/404 89/7206 0.001271418046 ko05323 Rheumatoid arthritis 13/404 89/7206 0.001271418046 ko04080 Neuroactive ligand-receptor interaction 10/404 423/7206 0.00146332627171 ko00950 Isoquinoline alkaloid biosynthesis 4/404 10/7206 0.00155951789104 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 3/404 5/7206 0.00160700768441 ko03013 RNA transport 1/404 166/7206 0.00162011472302 ko05131 Shigellosis 12/404 82/7206 0.00190378942378 ko00590 Arachidonic acid metabolism 9/404 52/7206 0.00214081723245 ko05142 Chagas disease (American trypanosomiasis) 16/404 130/7206 0.00288864236257 ko04310 Wnt signaling pathway 2/404 181/7206 0.00299159133822 ko05132 Salmonella infection 13/404 98/7206 0.00307639670758 ko05144 Malaria 8/404 45/7206 0.00314446579489 ko00592 alpha-Linolenic acid metabolism 5/404 19/7206 0.00326475519433 ko04612 Antigen processing and presentation 11/404 77/7206 0.00352314753474 ko00982 Drug metabolism - cytochrome P450 7/404 37/7206 0.00393467473709 ko04916 Melanogenesis 1/404 142/7206 0.00481522472664 ko04062 Chemokine signaling pathway 21/404 201/7206 0.00485338387893 ko03040 Spliceosome 1/404 145/7206 0.00504995325363 ko00980 Metabolism of xenobiotics by cytochrome P450 7/404 40/7206 0.0061659848827 ko04623 Cytosolic DNA-sensing pathway 7/404 41/7206 0.0070863005263 ko04668 TNF signaling pathway 14/404 120/7206 0.00793173654008 ko04390 Hippo signaling pathway 3/404 188/7206 0.009612774453 ko03010 Ribosome 1/404 129/7206 0.0103266207987 ko04664 Fc epsilon RI signaling pathway 10/404 77/7206 0.0103590885669 ko05161 Hepatitis B 18/404 173/7206 0.0107496770852 ko00071 Fatty acid degradation 7/404 45/7206 0.0118062023879 ko04217 Necroptosis 18/404 178/7206 0.012791120789 ko04911 Insulin secretion 1/404 117/7206 0.0145267198527 ko04068 FoxO signaling pathway 17/404 167/7206 0.0157288590278 ko05204 Chemical carcinogenesis 7/404 48/7206 0.0165969475116 ko04110 Cell cycle 2/404 145/7206 0.0172702895123 ko01212 Fatty acid metabolism 8/404 60/7206 0.0179918177066 ko04723 Retrograde endocannabinoid signaling 3/404 175/7206 0.0186322866199 ko04210 Apoptosis 18/404 180/7206 0.0196251171055 ko02010 ABC transporters 6/404 39/7206 0.0202507452248 ko04727 GABAergic synapse 1/404 110/7206 0.0210084842263 ko04972 Pancreatic secretion 1/404 111/7206 0.0210161363415 ko05320 Autoimmune thyroid disease 5/404 29/7206 0.021043600781 ko04137 Mitophagy - animal 10/404 82/7206 0.024355089963 ko04666 Fc gamma R-mediated phagocytosis 13/404 122/7206 0.0256388958788 ko05418 Fluid shear stress and atherosclerosis 17/404 173/7206 0.0272183608357 ko00281 Geraniol degradation 2/404 5/7206 0.0280028938952 ko00051 Fructose and mannose metabolism 6/404 42/7206 0.0283048961849 ko04917 Prolactin signaling pathway 10/404 87/7206 0.0294725252741 ko00480 Glutathione metabolism 7/404 55/7206 0.0327968689751 ko04728 Dopaminergic synapse 4/404 185/7206 0.0346092013488 ko00362 Benzoate degradation 2/404 6/7206 0.0404640541746 ko05330 Allograft rejection 4/404 24/7206 0.0424332847218 ko00220 Arginine biosynthesis 4/404 24/7206 0.0424332847218 ko04540 Gap junction 2/404 128/7206 0.0490136228431