ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 41/407 191/7206 3.97220149106e-14 ko04380 Osteoclast differentiation 32/407 134/7206 1.34830835297e-12 ko05164 Influenza A 36/407 167/7206 1.36620032241e-12 ko04621 NOD-like receptor signaling pathway 32/407 157/7206 1.21220629072e-10 ko05340 Primary immunodeficiency 14/407 30/7206 1.71044038089e-10 ko05162 Measles 26/407 120/7206 1.78573330508e-09 ko04650 Natural killer cell mediated cytotoxicity 23/407 97/7206 2.47187620763e-09 ko05140 Leishmaniasis 20/407 75/7206 3.09473268963e-09 ko05145 Toxoplasmosis 26/407 126/7206 5.37875458927e-09 ko05321 Inflammatory bowel disease (IBD) 17/407 56/7206 5.55407990595e-09 ko05152 Tuberculosis 31/407 187/7206 4.42601276669e-08 ko04217 Necroptosis 29/407 178/7206 1.80310691278e-07 ko04064 NF-kappa B signaling pathway 20/407 96/7206 2.75972097202e-07 ko05168 Herpes simplex infection 29/407 182/7206 2.94281077847e-07 ko04659 Th17 cell differentiation 21/407 106/7206 3.40518612057e-07 ko04620 Toll-like receptor signaling pathway 20/407 100/7206 5.54450652156e-07 ko05167 Kaposi's sarcoma-associated herpesvirus infection 29/407 191/7206 8.34823678116e-07 ko04612 Antigen processing and presentation 17/407 77/7206 9.24457662893e-07 ko04658 Th1 and Th2 cell differentiation 19/407 96/7206 1.26319629593e-06 ko04610 Complement and coagulation cascades 17/407 79/7206 1.35643220021e-06 ko05150 Staphylococcus aureus infection 11/407 36/7206 2.71345227618e-06 ko05330 Allograft rejection 9/407 24/7206 3.27692946303e-06 ko00120 Primary bile acid biosynthesis 8/407 20/7206 6.6768307921e-06 ko04630 Jak-STAT signaling pathway 21/407 132/7206 1.35276763703e-05 ko04660 T cell receptor signaling pathway 20/407 124/7206 1.76257182643e-05 ko05320 Autoimmune thyroid disease 9/407 29/7206 1.94836147503e-05 ko05133 Pertussis 16/407 87/7206 2.32503213437e-05 ko04672 Intestinal immune network for IgA production 10/407 37/7206 2.59844351141e-05 ko04662 B cell receptor signaling pathway 16/407 88/7206 2.69732391064e-05 ko05332 Graft-versus-host disease 7/407 18/7206 3.21785755672e-05 ko04622 RIG-I-like receptor signaling pathway 13/407 62/7206 3.22704810618e-05 ko05161 Hepatitis B 24/407 173/7206 3.53910855241e-05 ko04137 Mitophagy - animal 15/407 82/7206 4.46127725959e-05 ko04640 Hematopoietic cell lineage 13/407 64/7206 4.60149135532e-05 ko04145 Phagosome 22/407 162/7206 0.000103392025446 ko05310 Asthma 6/407 17/7206 0.000227128208619 ko04062 Chemokine signaling pathway 25/407 201/7206 0.000245805799308 ko04623 Cytosolic DNA-sensing pathway 9/407 41/7206 0.000372114200715 ko05323 Rheumatoid arthritis 14/407 89/7206 0.000418287725904 ko05160 Hepatitis C 20/407 153/7206 0.000479920244076 ko05144 Malaria 9/407 45/7206 0.000769983138799 ko04611 Platelet activation 20/407 163/7206 0.000881341816598 ko04668 TNF signaling pathway 16/407 120/7206 0.00109596202182 ko05132 Salmonella infection 14/407 98/7206 0.00112421725618 ko05142 Chagas disease (American trypanosomiasis) 17/407 130/7206 0.00145271899136 ko04940 Type I diabetes mellitus 7/407 32/7206 0.00171001066334 ko04390 Hippo signaling pathway 2/407 188/7206 0.00208610267975 ko04310 Wnt signaling pathway 2/407 181/7206 0.00298506829431 ko04080 Neuroactive ligand-receptor interaction 11/407 423/7206 0.00320111395451 ko03040 Spliceosome 1/407 145/7206 0.00325083441819 ko04664 Fc epsilon RI signaling pathway 11/407 77/7206 0.00372826600928 ko05034 Alcoholism 4/407 238/7206 0.00385624714423 ko04723 Retrograde endocannabinoid signaling 2/407 175/7206 0.00427756727817 ko05131 Shigellosis 11/407 82/7206 0.00607052503222 ko04670 Leukocyte transendothelial migration 17/407 151/7206 0.00629413831948 ko00140 Steroid hormone biosynthesis 7/407 41/7206 0.00737212328083 ko04210 Apoptosis 19/407 180/7206 0.00788968715669 ko00590 Arachidonic acid metabolism 8/407 52/7206 0.00814401110517 ko00051 Fructose and mannose metabolism 7/407 42/7206 0.00842853676149 ko04666 Fc gamma R-mediated phagocytosis 14/407 122/7206 0.00938621049018 ko03010 Ribosome 1/407 129/7206 0.0104733471977 ko05416 Viral myocarditis 8/407 55/7206 0.0113762396748 ko05224 Breast cancer 3/407 174/7206 0.0186470774508 ko05010 Alzheimer's disease 4/407 202/7206 0.0190460192601 ko05166 HTLV-I infection 26/407 292/7206 0.0191744291012 ko00592 alpha-Linolenic acid metabolism 4/407 19/7206 0.019755828183 ko05169 Epstein-Barr virus infection 20/407 206/7206 0.0199011639671 ko04972 Pancreatic secretion 1/407 111/7206 0.0210530528027 ko04933 AGE-RAGE signaling pathway in diabetic complications 14/407 135/7206 0.0231334819116 ko00980 Metabolism of xenobiotics by cytochrome P450 6/407 40/7206 0.0234856255393 ko04916 Melanogenesis 2/407 142/7206 0.0250774842475 ko05146 Amoebiasis 11/407 99/7206 0.0263310921429 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 2/407 5/7206 0.0283965097762 ko03050 Proteasome 7/407 54/7206 0.0310793327492 ko04728 Dopaminergic synapse 4/407 185/7206 0.0346903838695 ko05134 Legionellosis 9/407 74/7206 0.03599029086 ko04072 Phospholipase D signaling pathway 18/407 197/7206 0.0403828763497 ko04530 Tight junction 6/407 228/7206 0.0410404337031 ko04360 Axon guidance 6/407 233/7206 0.04165526178 ko00220 Arginine biosynthesis 4/407 24/7206 0.0434211884675 ko04260 Cardiac muscle contraction 1/407 98/7206 0.0441689308224 ko05418 Fluid shear stress and atherosclerosis 16/407 173/7206 0.0447505349519 ko04724 Glutamatergic synapse 3/407 152/7206 0.0485684528738 ko00190 Oxidative phosphorylation 2/407 127/7206 0.0489500148611 ko04540 Gap junction 2/407 128/7206 0.0495161512385 ko05012 Parkinson's disease 3/407 155/7206 0.0497945524477