ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko05033	Nicotine addiction	43/644	56/7206	1.33691588054e-34
ko04724	Glutamatergic synapse	68/644	152/7206	2.45553754885e-32
ko05032	Morphine addiction	56/644	110/7206	1.96838236874e-30
ko04727	GABAergic synapse	52/644	110/7206	2.55058675146e-26
ko04723	Retrograde endocannabinoid signaling	63/644	175/7206	1.13033530723e-23
ko04080	Neuroactive ligand-receptor interaction	103/644	423/7206	1.06853948698e-22
ko04713	Circadian entrainment	52/644	136/7206	4.53509559253e-21
ko04728	Dopaminergic synapse	61/644	185/7206	1.12504885087e-20
ko04725	Cholinergic synapse	52/644	160/7206	1.87743449705e-17
ko04024	cAMP signaling pathway	69/644	279/7206	1.01972158294e-15
ko04744	Phototransduction	22/644	36/7206	6.86291203388e-15
ko04721	Synaptic vesicle cycle	31/644	80/7206	3.24885208925e-13
ko04921	Oxytocin signaling pathway	52/644	209/7206	3.38212002535e-12
ko04911	Insulin secretion	36/644	117/7206	1.19217536743e-11
ko05031	Amphetamine addiction	31/644	91/7206	1.73165225152e-11
ko04726	Serotonergic synapse	39/644	137/7206	2.39229553862e-11
ko05030	Cocaine addiction	27/644	73/7206	4.0506035057e-11
ko04261	Adrenergic signaling in cardiomyocytes	48/644	205/7206	2.35417841113e-10
ko04742	Taste transduction	23/644	61/7206	7.38403220626e-10
ko04720	Long-term potentiation	29/644	99/7206	4.42396360771e-09
ko04010	MAPK signaling pathway	61/644	321/7206	8.89889051845e-09
ko04020	Calcium signaling pathway	52/644	265/7206	3.42213720497e-08
ko04740	Olfactory transduction	23/644	80/7206	2.60957255133e-07
ko05203	Viral carcinogenesis	5/644	277/7206	9.05668975002e-07
ko04072	Phospholipase D signaling pathway	39/644	197/7206	1.50656281992e-06
ko04925	Aldosterone synthesis and secretion	25/644	105/7206	3.79372911465e-06
ko04730	Long-term depression	20/644	78/7206	1.08452798047e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	19/644	79/7206	4.73670506671e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	18/644	74/7206	6.36130445305e-05
ko05414	Dilated cardiomyopathy	24/644	112/7206	6.47515067984e-05
ko04970	Salivary secretion	21/644	95/7206	7.31934551035e-05
ko04915	Estrogen signaling pathway	26/644	131/7206	7.95247533254e-05
ko04060	Cytokine-cytokine receptor interaction	4/644	191/7206	0.000158489534942
ko04110	Cell cycle	2/644	145/7206	0.000303708091286
ko04260	Cardiac muscle contraction	20/644	98/7206	0.000436390893556
ko04514	Cell adhesion molecules (CAMs)	24/644	130/7206	0.000506801908352
ko03013	RNA transport	4/644	166/7206	0.00129947181426
ko04350	TGF-beta signaling pathway	1/644	103/7206	0.0013485921422
ko05034	Alcoholism	36/644	238/7206	0.00161960009646
ko04972	Pancreatic secretion	20/644	111/7206	0.00209997629262
ko04360	Axon guidance	35/644	233/7206	0.00216587681882
ko04022	cGMP-PKG signaling pathway	33/644	216/7206	0.00220040936573
ko04070	Phosphatidylinositol signaling system	20/644	112/7206	0.00227984078838
ko04930	Type II diabetes mellitus	12/644	54/7206	0.00241174404616
ko04971	Gastric acid secretion	18/644	98/7206	0.0033974013203
ko05322	Systemic lupus erythematosus	4/644	151/7206	0.00348887726798
ko05410	Hypertrophic cardiomyopathy (HCM)	18/644	100/7206	0.00384230928221
ko04014	Ras signaling pathway	39/644	279/7206	0.00503982256094
ko05168	Herpes simplex infection	6/644	182/7206	0.00516050073991
ko04932	Non-alcoholic fatty liver disease (NAFLD)	6/644	182/7206	0.00516050073991
ko04745	Phototransduction - fly	9/644	38/7206	0.00526949558548
ko05205	Proteoglycans in cancer	12/644	271/7206	0.00630460590967
ko03008	Ribosome biogenesis in eukaryotes	1/644	79/7206	0.00901104264933
ko05231	Choline metabolism in cancer	21/644	134/7206	0.00913284189287
ko04750	Inflammatory mediator regulation of TRP channels	20/644	122/7206	0.00922336915459
ko04120	Ubiquitin mediated proteolysis	4/644	138/7206	0.00943781832393
ko05131	Shigellosis	1/644	82/7206	0.00952924868833
ko04540	Gap junction	20/644	128/7206	0.0117540043995
ko04141	Protein processing in endoplasmic reticulum	7/644	184/7206	0.0120213397527
ko05164	Influenza A	6/644	167/7206	0.0125538992368
ko04666	Fc gamma R-mediated phagocytosis	19/644	122/7206	0.0152487635472
ko04145	Phagosome	6/644	162/7206	0.0167823940205
ko00240	Pyrimidine metabolism	3/644	110/7206	0.0171473736053
ko04961	Endocrine and other factor-regulated calcium reabsorption	11/644	59/7206	0.0180196991778
ko03320	PPAR signaling pathway	1/644	69/7206	0.0191922395425
ko00310	Lysine degradation	1/644	73/7206	0.0202865107109
ko04923	Regulation of lipolysis in adipocytes	13/644	77/7206	0.0241320264042
ko04012	ErbB signaling pathway	17/644	109/7206	0.0255302531624
ko04670	Leukocyte transendothelial migration	6/644	151/7206	0.0294212192198
ko00604	Glycosphingolipid biosynthesis - ganglio series	4/644	14/7206	0.0306230027097
ko04062	Chemokine signaling pathway	27/644	201/7206	0.0318950533362
ko03018	RNA degradation	2/644	84/7206	0.0320528119747
ko05169	Epstein-Barr virus infection	10/644	206/7206	0.0347855975314
ko00562	Inositol phosphate metabolism	14/644	89/7206	0.0366181699026
ko01212	Fatty acid metabolism	1/644	60/7206	0.0405728337752
ko04015	Rap1 signaling pathway	35/644	278/7206	0.0406369243518
ko00330	Arginine and proline metabolism	1/644	61/7206	0.0406691635278
ko04640	Hematopoietic cell lineage	1/644	64/7206	0.0428806530145
ko04371	Apelin signaling pathway	24/644	177/7206	0.043722470368
ko04621	NOD-like receptor signaling pathway	7/644	157/7206	0.0468142251688
ko04071	Sphingolipid signaling pathway	22/644	162/7206	0.049304448302