ko pathway ratio_in_study ratio_in_pop p_value ko05217 Basal cell carcinoma 32/526 68/7206 3.62503412142e-19 ko04550 Signaling pathways regulating pluripotency of stem cells 46/526 165/7206 4.09444005055e-16 ko04080 Neuroactive ligand-receptor interaction 3/526 423/7206 6.13456889548e-11 ko05224 Breast cancer 38/526 174/7206 5.03628707221e-10 ko03040 Spliceosome 34/526 145/7206 5.81433059215e-10 ko04330 Notch signaling pathway 21/526 62/7206 9.89462936293e-10 ko04390 Hippo signaling pathway 39/526 188/7206 1.4533334618e-09 ko04310 Wnt signaling pathway 38/526 181/7206 1.66491767665e-09 ko04110 Cell cycle 32/526 145/7206 9.36913210865e-09 ko04340 Hedgehog signaling pathway 19/526 58/7206 1.18314500632e-08 ko03030 DNA replication 15/526 38/7206 2.34628505443e-08 ko04360 Axon guidance 40/526 233/7206 2.51379445904e-07 ko05200 Pathways in cancer 66/526 492/7206 8.70698702834e-07 ko04111 Cell cycle - yeast 21/526 90/7206 1.31301323228e-06 ko03015 mRNA surveillance pathway 21/526 93/7206 2.32153898491e-06 ko05166 HTLV-I infection 44/526 292/7206 2.86242751382e-06 ko04950 Maturity onset diabetes of the young 11/526 29/7206 2.91174661539e-06 ko04921 Oxytocin signaling pathway 1/526 209/7206 4.33624053054e-06 ko05202 Transcriptional misregulation in cancer 32/526 188/7206 5.24881124634e-06 ko05010 Alzheimer's disease 1/526 202/7206 6.18370723435e-06 ko04020 Calcium signaling pathway 4/526 265/7206 3.04440767231e-05 ko03410 Base excision repair 11/526 38/7206 5.53048809717e-05 ko05205 Proteoglycans in cancer 38/526 271/7206 0.000106720626894 ko04270 Vascular smooth muscle contraction 1/526 154/7206 0.000215702804553 ko04932 Non-alcoholic fatty liver disease (NAFLD) 2/526 182/7206 0.000224907842625 ko04723 Retrograde endocannabinoid signaling 2/526 175/7206 0.000318437318001 ko04113 Meiosis - yeast 14/526 70/7206 0.00043788266443 ko04022 cGMP-PKG signaling pathway 4/526 216/7206 0.000487590046535 ko05206 MicroRNAs in cancer 26/526 177/7206 0.000586518755321 ko04144 Endocytosis 10/526 342/7206 0.000596209247057 ko04726 Serotonergic synapse 1/526 137/7206 0.000678357987 ko04621 NOD-like receptor signaling pathway 2/526 157/7206 0.000951603063573 ko03013 RNA transport 24/526 166/7206 0.00121506448568 ko04062 Chemokine signaling pathway 4/526 201/7206 0.00135781866578 ko04350 TGF-beta signaling pathway 17/526 103/7206 0.00153969417227 ko04916 Melanogenesis 21/526 142/7206 0.00163336728355 ko04919 Thyroid hormone signaling pathway 21/526 143/7206 0.00174928963545 ko04072 Phospholipase D signaling pathway 4/526 197/7206 0.00193216443135 ko00240 Pyrimidine metabolism 17/526 110/7206 0.00263559789859 ko04972 Pancreatic secretion 1/526 111/7206 0.00471138213372 ko04725 Cholinergic synapse 3/526 160/7206 0.00490375771831 ko04217 Necroptosis 4/526 178/7206 0.0050900762238 ko03420 Nucleotide excision repair 9/526 46/7206 0.00528921758556 ko04391 Hippo signaling pathway - fly 14/526 90/7206 0.00636651738102 ko04650 Natural killer cell mediated cytotoxicity 1/526 97/7206 0.00955242294958 ko04971 Gastric acid secretion 1/526 98/7206 0.00964230377052 ko04612 Antigen processing and presentation 12/526 77/7206 0.0122172713678 ko05222 Small cell lung cancer 13/526 89/7206 0.0130964782454 ko04970 Salivary secretion 1/526 95/7206 0.0147132357267 ko04371 Apelin signaling pathway 5/526 177/7206 0.0180709030324 ko04713 Circadian entrainment 3/526 136/7206 0.0181971047124 ko04341 Hedgehog signaling pathway - fly 7/526 38/7206 0.0184255476497 ko03430 Mismatch repair 5/526 22/7206 0.0189297790522 ko04920 Adipocytokine signaling pathway 1/526 89/7206 0.0210935495399 ko04910 Insulin signaling pathway 5/526 172/7206 0.0245152484386 ko01200 Carbon metabolism 3/526 128/7206 0.0247199290763 ko04915 Estrogen signaling pathway 3/526 131/7206 0.0254258593777 ko04610 Complement and coagulation cascades 1/526 79/7206 0.0291542424075 ko04721 Synaptic vesicle cycle 1/526 80/7206 0.0291905869217 ko04976 Bile secretion 1/526 80/7206 0.0291905869217 ko04138 Autophagy - yeast 1/526 81/7206 0.0293844111 ko04137 Mitophagy - animal 1/526 82/7206 0.0297355996596 ko03460 Fanconi anemia pathway 8/526 51/7206 0.0300510945279 ko04141 Protein processing in endoplasmic reticulum 6/526 184/7206 0.030367171305 ko05034 Alcoholism 9/526 238/7206 0.0308100190997 ko04611 Platelet activation 5/526 163/7206 0.0321893355399 ko04912 GnRH signaling pathway 3/526 122/7206 0.0340691916342 ko04925 Aldosterone synthesis and secretion 2/526 105/7206 0.0344212540263 ko00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin 5/526 26/7206 0.0372126414591 ko04150 mTOR signaling pathway 21/526 184/7206 0.0424863491045 ko04923 Regulation of lipolysis in adipocytes 1/526 77/7206 0.0433551546367 ko04730 Long-term depression 1/526 78/7206 0.0441802142584 ko04512 ECM-receptor interaction 11/526 79/7206 0.0452186837142 ko03008 Ribosome biogenesis in eukaryotes 11/526 79/7206 0.0452186837142 ko04931 Insulin resistance 4/526 137/7206 0.0454244259193 ko04911 Insulin secretion 3/526 117/7206 0.0469635979155 ko04260 Cardiac muscle contraction 2/526 98/7206 0.0472708493246 ko04720 Long-term potentiation 2/526 99/7206 0.0479693427087 ko04139 Mitophagy - yeast 6/526 37/7206 0.0493625655696