ko pathway ratio_in_study ratio_in_pop p_value ko04070 Phosphatidylinositol signaling system 13/141 112/7206 2.29267148819e-07 ko04713 Circadian entrainment 13/141 136/7206 2.18543431638e-06 ko04921 Oxytocin signaling pathway 15/141 209/7206 1.26864103501e-05 ko04925 Aldosterone synthesis and secretion 10/141 105/7206 3.53671659719e-05 ko04020 Calcium signaling pathway 16/141 265/7206 5.49922685408e-05 ko04911 Insulin secretion 10/141 117/7206 8.95700439029e-05 ko04970 Salivary secretion 9/141 95/7206 9.17588177601e-05 ko04971 Gastric acid secretion 9/141 98/7206 0.00011694121525 ko04966 Collecting duct acid secretion 5/141 26/7206 0.000126187456271 ko04720 Long-term potentiation 9/141 99/7206 0.000126524871429 ko04721 Synaptic vesicle cycle 8/141 80/7206 0.000155706740032 ko05110 Vibrio cholerae infection 7/141 63/7206 0.000209672509624 ko04728 Dopaminergic synapse 12/141 185/7206 0.000254286546217 ko04725 Cholinergic synapse 11/141 160/7206 0.000280315508737 ko04626 Plant-pathogen interaction 4/141 18/7206 0.000347246176686 ko05031 Amphetamine addiction 8/141 91/7206 0.000381083255079 ko05120 Epithelial cell signaling in Helicobacter pylori infection 8/141 92/7206 0.000410586672373 ko04261 Adrenergic signaling in cardiomyocytes 12/141 205/7206 0.000647214501164 ko04724 Glutamatergic synapse 10/141 152/7206 0.000753006522545 ko04745 Phototransduction - fly 5/141 38/7206 0.000797441442805 ko00190 Oxidative phosphorylation 9/141 127/7206 0.000815707017203 ko04071 Sphingolipid signaling pathway 10/141 162/7206 0.00122974668963 ko04924 Renin secretion 7/141 86/7206 0.00140188830841 ko04919 Thyroid hormone signaling pathway 9/141 143/7206 0.00188462287632 ko04750 Inflammatory mediator regulation of TRP channels 8/141 122/7206 0.00259981959644 ko04022 cGMP-PKG signaling pathway 11/141 216/7206 0.00328921752693 ko05152 Tuberculosis 10/141 187/7206 0.00354977735081 ko05214 Glioma 6/141 79/7206 0.00434732212882 ko04727 GABAergic synapse 7/141 110/7206 0.00563539397416 ko05010 Alzheimer's disease 10/141 202/7206 0.00610634672866 ko05323 Rheumatoid arthritis 6/141 89/7206 0.00775553046769 ko04142 Lysosome 8/141 151/7206 0.00934939189514 ko04710 Circadian rhythm 4/141 43/7206 0.00959895691687 ko04912 GnRH signaling pathway 7/141 122/7206 0.00978151254668 ko04270 Vascular smooth muscle contraction 8/141 154/7206 0.0104621150064 ko04015 Rap1 signaling pathway 12/141 278/7206 0.0117851028792 ko04024 cAMP signaling pathway 12/141 279/7206 0.0119345824086 ko04014 Ras signaling pathway 12/141 279/7206 0.0119345824086 ko01040 Biosynthesis of unsaturated fatty acids 3/141 25/7206 0.0123083207082 ko04922 Glucagon signaling pathway 7/141 128/7206 0.0125374100311 ko04722 Neurotrophin signaling pathway 8/141 160/7206 0.0129789981398 ko04145 Phagosome 8/141 162/7206 0.0139092984709 ko04933 AGE-RAGE signaling pathway in diabetic complications 7/141 135/7206 0.0164150164902 ko04730 Long-term depression 5/141 78/7206 0.0180144922094 ko04114 Oocyte meiosis 7/141 139/7206 0.0189783412363 ko02025 Biofilm formation - Pseudomonas aeruginosa 1/141 1/7206 0.0195670274772 ko04740 Olfactory transduction 5/141 80/7206 0.0198920965721 ko04138 Autophagy - yeast 5/141 81/7206 0.0208772934055 ko04916 Melanogenesis 7/141 142/7206 0.021076888891 ko04371 Apelin signaling pathway 8/141 177/7206 0.0225033908661 ko00562 Inositol phosphate metabolism 5/141 89/7206 0.0299154431619 ko04066 HIF-1 signaling pathway 6/141 123/7206 0.0332148019928 ko04152 AMPK signaling pathway 7/141 161/7206 0.0382038124721 ko04650 Natural killer cell mediated cytotoxicity 5/141 97/7206 0.0411040470162 ko04960 Aldosterone-regulated sodium reabsorption 3/141 41/7206 0.0455398268778 ko04360 Axon guidance 9/141 233/7206 0.0480243427003