ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 12/108 152/7206 2.45200398061e-06 ko04720 Long-term potentiation 9/108 99/7206 1.53678585078e-05 ko04728 Dopaminergic synapse 12/108 185/7206 1.86168571804e-05 ko04725 Cholinergic synapse 11/108 160/7206 2.46937204e-05 ko04713 Circadian entrainment 10/108 136/7206 3.30906581457e-05 ko04020 Calcium signaling pathway 14/108 265/7206 3.69482698815e-05 ko04723 Retrograde endocannabinoid signaling 11/108 175/7206 5.65870964706e-05 ko05031 Amphetamine addiction 8/108 91/7206 5.94912987132e-05 ko04925 Aldosterone synthesis and secretion 8/108 105/7206 0.000164139508494 ko04727 GABAergic synapse 8/108 110/7206 0.000226736131092 ko05032 Morphine addiction 8/108 110/7206 0.000226736131092 ko04745 Phototransduction - fly 5/108 38/7206 0.000233303061577 ko04024 cAMP signaling pathway 13/108 279/7206 0.000252388239647 ko04742 Taste transduction 6/108 61/7206 0.000280384732866 ko04912 GnRH signaling pathway 8/108 122/7206 0.000459459624046 ko05030 Cocaine addiction 6/108 73/7206 0.000743430118662 ko00510 N-Glycan biosynthesis 5/108 50/7206 0.000853985902858 ko04261 Adrenergic signaling in cardiomyocytes 10/108 205/7206 0.00095229251609 ko04726 Serotonergic synapse 8/108 137/7206 0.00099107793421 ko04730 Long-term depression 6/108 78/7206 0.00105597124411 ko04921 Oxytocin signaling pathway 10/108 209/7206 0.00110395512751 ko04740 Olfactory transduction 6/108 80/7206 0.00120594768468 ko05230 Central carbon metabolism in cancer 6/108 81/7206 0.00128679896847 ko04080 Neuroactive ligand-receptor interaction 15/108 423/7206 0.00150151154796 ko04922 Glucagon signaling pathway 7/108 128/7206 0.00298828174801 ko04971 Gastric acid secretion 6/108 98/7206 0.00340070819095 ko04915 Estrogen signaling pathway 7/108 131/7206 0.00340143625534 ko00513 Various types of N-glycan biosynthesis 4/108 42/7206 0.0034471787576 ko04371 Apelin signaling pathway 8/108 177/7206 0.00493272248717 ko04916 Melanogenesis 7/108 142/7206 0.00529908064452 ko04138 Autophagy - yeast 5/108 81/7206 0.00716228489847 ko04360 Axon guidance 9/108 233/7206 0.00803844265493 ko04911 Insulin secretion 6/108 117/7206 0.00804421790632 ko04930 Type II diabetes mellitus 4/108 54/7206 0.00849305595051 ko04924 Renin secretion 5/108 86/7206 0.00918038826088 ko04072 Phospholipase D signaling pathway 8/108 197/7206 0.00923996832064 ko05033 Nicotine addiction 4/108 56/7206 0.00964180618564 ko04750 Inflammatory mediator regulation of TRP channels 6/108 122/7206 0.00979251070951 ko04211 Longevity regulating pathway 6/108 123/7206 0.0101723052458 ko04611 Platelet activation 7/108 163/7206 0.010997371147 ko04140 Autophagy - animal 7/108 164/7206 0.0113493379091 ko04540 Gap junction 6/108 128/7206 0.0122300720521 ko05231 Choline metabolism in cancer 6/108 134/7206 0.0150675800277 ko04914 Progesterone-mediated oocyte maturation 5/108 104/7206 0.0196400479332 ko04012 ErbB signaling pathway 5/108 109/7206 0.0235388296191 ko05034 Alcoholism 8/108 238/7206 0.0260589821033 ko04070 Phosphatidylinositol signaling system 5/108 112/7206 0.0261026356926 ko04923 Regulation of lipolysis in adipocytes 4/108 77/7206 0.0280111767733 ko05214 Glioma 4/108 79/7206 0.0304079084525 ko04062 Chemokine signaling pathway 7/108 201/7206 0.0308968599384 ko04722 Neurotrophin signaling pathway 6/108 160/7206 0.0326611105123 ko04066 HIF-1 signaling pathway 5/108 123/7206 0.0370042548746 ko00380 Tryptophan metabolism 3/108 50/7206 0.0385920791444 ko04213 Longevity regulating pathway - multiple species 4/108 86/7206 0.0397289030278 ko04022 cGMP-PKG signaling pathway 7/108 216/7206 0.0430233863655 ko04910 Insulin signaling pathway 6/108 172/7206 0.0440318762263 ko04146 Peroxisome 4/108 89/7206 0.0441706247223 ko04112 Cell cycle - Caulobacter 1/108 3/7206 0.044298076754 ko05142 Chagas disease (American trypanosomiasis) 5/108 130/7206 0.0452103329052