ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	193/1276	423/7206	4.40097226868e-43
ko04724	Glutamatergic synapse	87/1276	152/7206	1.88913472426e-28
ko05033	Nicotine addiction	47/1276	56/7206	3.28183172824e-27
ko05032	Morphine addiction	68/1276	110/7206	3.52139605461e-25
ko04713	Circadian entrainment	77/1276	136/7206	7.25782164454e-25
ko04727	GABAergic synapse	66/1276	110/7206	2.03245102756e-23
ko04721	Synaptic vesicle cycle	51/1276	80/7206	4.93838192243e-20
ko04728	Dopaminergic synapse	86/1276	185/7206	5.51439543292e-20
ko04725	Cholinergic synapse	75/1276	160/7206	8.03579333418e-18
ko04723	Retrograde endocannabinoid signaling	77/1276	175/7206	2.60150272279e-16
ko04744	Phototransduction	29/1276	36/7206	2.7833724464e-16
ko04024	cAMP signaling pathway	104/1276	279/7206	2.39115313376e-15
ko04742	Taste transduction	38/1276	61/7206	9.22224699015e-15
ko04911	Insulin secretion	56/1276	117/7206	4.24657599855e-14
ko04726	Serotonergic synapse	62/1276	137/7206	4.71847999465e-14
ko04020	Calcium signaling pathway	95/1276	265/7206	8.37360608851e-13
ko04921	Oxytocin signaling pathway	79/1276	209/7206	2.45618584009e-12
ko04740	Olfactory transduction	41/1276	80/7206	6.94486870851e-12
ko05031	Amphetamine addiction	43/1276	91/7206	6.74992004605e-11
ko03040	Spliceosome	2/1276	145/7206	3.62894469452e-10
ko04970	Salivary secretion	43/1276	95/7206	3.79899577518e-10
ko04261	Adrenergic signaling in cardiomyocytes	73/1276	205/7206	5.99512671371e-10
ko04720	Long-term potentiation	42/1276	99/7206	1.04008533524e-08
ko05203	Viral carcinogenesis	17/1276	277/7206	1.27299963031e-08
ko04925	Aldosterone synthesis and secretion	43/1276	105/7206	1.7263252816e-08
ko05168	Herpes simplex infection	8/1276	182/7206	6.64458865105e-08
ko04120	Ubiquitin mediated proteolysis	4/1276	138/7206	1.06717816984e-07
ko03013	RNA transport	7/1276	166/7206	2.58890772523e-07
ko04971	Gastric acid secretion	39/1276	98/7206	2.85944713307e-07
ko04621	NOD-like receptor signaling pathway	7/1276	157/7206	7.51010611019e-07
ko04966	Collecting duct acid secretion	16/1276	26/7206	7.61138377901e-07
ko04976	Bile secretion	33/1276	80/7206	7.72795128827e-07
ko04972	Pancreatic secretion	41/1276	111/7206	1.0763978945e-06
ko04060	Cytokine-cytokine receptor interaction	11/1276	191/7206	1.72666126525e-06
ko05322	Systemic lupus erythematosus	7/1276	151/7206	2.32538333265e-06
ko05030	Cocaine addiction	30/1276	73/7206	2.80642725189e-06
ko04514	Cell adhesion molecules (CAMs)	44/1276	130/7206	7.29280279826e-06
ko05164	Influenza A	10/1276	167/7206	1.24424216458e-05
ko04924	Renin secretion	32/1276	86/7206	2.16175712767e-05
ko04110	Cell cycle	8/1276	145/7206	2.21504074084e-05
ko04745	Phototransduction - fly	18/1276	38/7206	2.41645846027e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1276	74/7206	3.88146675561e-05
ko05166	HTLV-I infection	27/1276	292/7206	4.29143887824e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1276	79/7206	4.5455679632e-05
ko04260	Cardiac muscle contraction	34/1276	98/7206	4.55694023394e-05
ko05162	Measles	6/1276	120/7206	5.27706622549e-05
ko04022	cGMP-PKG signaling pathway	62/1276	216/7206	5.78852343814e-05
ko04750	Inflammatory mediator regulation of TRP channels	39/1276	122/7206	0.000106169871199
ko04141	Protein processing in endoplasmic reticulum	14/1276	184/7206	0.000115954033671
ko05169	Epstein-Barr virus infection	17/1276	206/7206	0.000130272242827
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1276	79/7206	0.000147666977503
ko04964	Proximal tubule bicarbonate reclamation	14/1276	29/7206	0.000151542447237
ko05110	Vibrio cholerae infection	24/1276	63/7206	0.000161704324441
ko05161	Hepatitis B	13/1276	173/7206	0.000164054799003
ko05205	Proteoglycans in cancer	26/1276	271/7206	0.000177699710686
ko04730	Long-term depression	27/1276	78/7206	0.00027766050775
ko04540	Gap junction	39/1276	128/7206	0.000385233652483
ko04064	NF-kappa B signaling pathway	5/1276	96/7206	0.000408313376025
ko04612	Antigen processing and presentation	3/1276	77/7206	0.00044267297653
ko05140	Leishmaniasis	3/1276	75/7206	0.000653112729039
ko04010	MAPK signaling pathway	80/1276	321/7206	0.000948446032265
ko05414	Dilated cardiomyopathy	34/1276	112/7206	0.00101793368823
ko04070	Phosphatidylinositol signaling system	34/1276	112/7206	0.00101793368823
ko04978	Mineral absorption	16/1276	40/7206	0.0011471475654
ko04360	Axon guidance	61/1276	233/7206	0.00116362220507
ko04217	Necroptosis	16/1276	178/7206	0.00135822732196
ko04657	IL-17 signaling pathway	5/1276	87/7206	0.00166899234639
ko04626	Plant-pathogen interaction	9/1276	18/7206	0.00174374913217
ko05219	Bladder cancer	1/1276	48/7206	0.00183736784961
ko05215	Prostate cancer	8/1276	111/7206	0.00236574460415
ko05321	Inflammatory bowel disease (IBD)	2/1276	56/7206	0.00244877102495
ko04630	Jak-STAT signaling pathway	11/1276	132/7206	0.00268895343512
ko03420	Nucleotide excision repair	1/1276	46/7206	0.00283023768895
ko04072	Phospholipase D signaling pathway	51/1276	197/7206	0.00328383091391
ko04923	Regulation of lipolysis in adipocytes	24/1276	77/7206	0.00383012593048
ko04330	Notch signaling pathway	3/1276	62/7206	0.0042001102854
ko04622	RIG-I-like receptor signaling pathway	3/1276	62/7206	0.0042001102854
ko03022	Basal transcription factors	1/1276	44/7206	0.00437255621641
ko04658	Th1 and Th2 cell differentiation	7/1276	96/7206	0.00452820564539
ko04214	Apoptosis - fly	4/1276	72/7206	0.00460614694234
ko05016	Huntington's disease	23/1276	215/7206	0.00483748293786
ko04915	Estrogen signaling pathway	36/1276	131/7206	0.00522465142123
ko04210	Apoptosis	18/1276	180/7206	0.0053621762581
ko04961	Endocrine and other factor-regulated calcium reabsorption	19/1276	59/7206	0.00580749228818
ko05145	Toxoplasmosis	11/1276	126/7206	0.00638801593156
ko00830	Retinol metabolism	15/1276	42/7206	0.00677006306294
ko03018	RNA degradation	6/1276	84/7206	0.00894454896851
ko04115	p53 signaling pathway	5/1276	74/7206	0.00909206446765
ko04371	Apelin signaling pathway	45/1276	177/7206	0.00923035122263
ko04142	Lysosome	15/1276	151/7206	0.00949329571729
ko04270	Vascular smooth muscle contraction	40/1276	154/7206	0.0100061804247
ko05200	Pathways in cancer	66/1276	492/7206	0.0100493237285
ko04014	Ras signaling pathway	66/1276	279/7206	0.0102963427883
ko04668	TNF signaling pathway	11/1276	120/7206	0.0110495321083
ko05410	Hypertrophic cardiomyopathy (HCM)	28/1276	100/7206	0.0114056479858
ko04930	Type II diabetes mellitus	17/1276	54/7206	0.0117481786764
ko05131	Shigellosis	6/1276	82/7206	0.0124177949764
ko00520	Amino sugar and nucleotide sugar metabolism	3/1276	55/7206	0.0124560626021
ko04922	Glucagon signaling pathway	34/1276	128/7206	0.0134855436984
ko00240	Pyrimidine metabolism	10/1276	110/7206	0.0161182306653
ko05144	Malaria	2/1276	45/7206	0.0169665987739
ko00330	Arginine and proline metabolism	4/1276	61/7206	0.0178929829
ko02010	ABC transporters	13/1276	39/7206	0.0182307150933
ko00965	Betalain biosynthesis	3/1276	4/7206	0.0192279646263
ko00290	Valine, leucine and isoleucine biosynthesis	3/1276	4/7206	0.0192279646263
ko03015	mRNA surveillance pathway	8/1276	93/7206	0.0193587540971
ko04510	Focal adhesion	29/1276	240/7206	0.0199542814812
ko05220	Chronic myeloid leukemia	7/1276	85/7206	0.0211704050905
ko04974	Protein digestion and absorption	26/1276	96/7206	0.0213060806333
ko04218	Cellular senescence	20/1276	177/7206	0.0217506641798
ko05206	MicroRNAs in cancer	20/1276	177/7206	0.0217506641798
ko04933	AGE-RAGE signaling pathway in diabetic complications	14/1276	135/7206	0.0225211812963
ko04620	Toll-like receptor signaling pathway	9/1276	100/7206	0.0238355220103
ko05217	Basal cell carcinoma	5/1276	68/7206	0.0241852039311
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1276	14/7206	0.0251810211426
ko05212	Pancreatic cancer	7/1276	83/7206	0.0286857847029
ko04932	Non-alcoholic fatty liver disease (NAFLD)	21/1276	182/7206	0.0298798873261
ko04912	GnRH signaling pathway	31/1276	122/7206	0.0307031964342
ko05202	Transcriptional misregulation in cancer	22/1276	188/7206	0.0325608824046
ko00350	Tyrosine metabolism	11/1276	33/7206	0.0353055900304
ko04140	Autophagy - animal	19/1276	164/7206	0.0381733398501
ko04550	Signaling pathways regulating pluripotency of stem cells	19/1276	165/7206	0.038402469129
ko00680	Methane metabolism	11/1276	34/7206	0.038865793846
ko04973	Carbohydrate digestion and absorption	13/1276	42/7206	0.0392793189589
ko04113	Meiosis - yeast	6/1276	70/7206	0.0412132422231
ko04710	Circadian rhythm	13/1276	43/7206	0.0426561728787
ko00230	Purine metabolism	45/1276	194/7206	0.0454090468713
ko05320	Autoimmune thyroid disease	1/1276	29/7206	0.0479652158689
ko00480	Glutathione metabolism	4/1276	55/7206	0.0488615871143