ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 52/603 152/7206 7.64239897949e-20 ko04721 Synaptic vesicle cycle 35/603 80/7206 1.21615813322e-17 ko04713 Circadian entrainment 42/603 136/7206 1.92671233235e-14 ko05033 Nicotine addiction 26/603 56/7206 3.49441332294e-14 ko04728 Dopaminergic synapse 49/603 185/7206 9.65427290669e-14 ko04911 Insulin secretion 36/603 117/7206 1.69953415069e-12 ko04080 Neuroactive ligand-receptor interaction 79/603 423/7206 2.78554332008e-12 ko04723 Retrograde endocannabinoid signaling 43/603 175/7206 5.00690600976e-11 ko04024 cAMP signaling pathway 57/603 279/7206 1.16298796976e-10 ko04727 GABAergic synapse 32/603 110/7206 1.55228510567e-10 ko04720 Long-term potentiation 30/603 99/7206 1.93393866955e-10 ko05032 Morphine addiction 31/603 110/7206 7.25777174967e-10 ko05031 Amphetamine addiction 27/603 91/7206 2.67245732901e-09 ko04921 Oxytocin signaling pathway 44/603 209/7206 5.85475140059e-09 ko04725 Cholinergic synapse 36/603 160/7206 2.43330558052e-08 ko04261 Adrenergic signaling in cardiomyocytes 41/603 205/7206 1.02912345469e-07 ko04966 Collecting duct acid secretion 12/603 26/7206 3.42167207631e-07 ko04970 Salivary secretion 24/603 95/7206 5.8656979652e-07 ko04745 Phototransduction - fly 14/603 38/7206 1.03618557333e-06 ko04744 Phototransduction 13/603 36/7206 3.29316033237e-06 ko04514 Cell adhesion molecules (CAMs) 27/603 130/7206 7.09892089114e-06 ko04022 cGMP-PKG signaling pathway 38/603 216/7206 8.30708937963e-06 ko05110 Vibrio cholerae infection 17/603 63/7206 1.01219536562e-05 ko04060 Cytokine-cytokine receptor interaction 2/603 191/7206 1.45755477339e-05 ko04020 Calcium signaling pathway 43/603 265/7206 2.07665730776e-05 ko04726 Serotonergic synapse 27/603 137/7206 2.51530979805e-05 ko05014 Amyotrophic lateral sclerosis (ALS) 18/603 74/7206 2.64803606846e-05 ko04925 Aldosterone synthesis and secretion 22/603 105/7206 4.32395629803e-05 ko04971 Gastric acid secretion 21/603 98/7206 4.53109565603e-05 ko04360 Axon guidance 38/603 233/7206 5.43864170123e-05 ko05030 Cocaine addiction 17/603 73/7206 7.99203814502e-05 ko03040 Spliceosome 1/603 145/7206 9.58758252954e-05 ko04972 Pancreatic secretion 22/603 111/7206 0.000160984676215 ko05120 Epithelial cell signaling in Helicobacter pylori infection 19/603 92/7206 0.000173779353469 ko04730 Long-term depression 17/603 78/7206 0.000190944085083 ko05168 Herpes simplex infection 3/603 182/7206 0.000192733195235 ko03010 Ribosome 1/603 129/7206 0.000294242038493 ko05322 Systemic lupus erythematosus 2/603 151/7206 0.000298144484457 ko04626 Plant-pathogen interaction 7/603 18/7206 0.000389174863033 ko04114 Oocyte meiosis 24/603 139/7206 0.000533043315491 ko00604 Glycosphingolipid biosynthesis - ganglio series 6/603 14/7206 0.00056057667448 ko04120 Ubiquitin mediated proteolysis 2/603 138/7206 0.000910723412944 ko05010 Alzheimer's disease 31/603 202/7206 0.00107118905348 ko04070 Phosphatidylinositol signaling system 20/603 112/7206 0.00147081343446 ko05203 Viral carcinogenesis 10/603 277/7206 0.00185020946996 ko04924 Renin secretion 16/603 86/7206 0.002325792842 ko04072 Phospholipase D signaling pathway 29/603 197/7206 0.00243502748233 ko04961 Endocrine and other factor-regulated calcium reabsorption 12/603 59/7206 0.00304976972248 ko05162 Measles 2/603 120/7206 0.00398714000797 ko04146 Peroxisome 1/603 89/7206 0.00628850699997 ko05169 Epstein-Barr virus infection 7/603 206/7206 0.00678966663044 ko05164 Influenza A 5/603 167/7206 0.00691687851945 ko04740 Olfactory transduction 14/603 80/7206 0.00692427608653 ko04014 Ras signaling pathway 36/603 279/7206 0.00787231845148 ko04964 Proximal tubule bicarbonate reclamation 7/603 29/7206 0.00849212605039 ko04260 Cardiac muscle contraction 16/603 98/7206 0.00874341142368 ko04657 IL-17 signaling pathway 1/603 87/7206 0.00957582936639 ko04010 MAPK signaling pathway 40/603 321/7206 0.00965410584099 ko03013 RNA transport 5/603 166/7206 0.00976429453753 ko04621 NOD-like receptor signaling pathway 5/603 157/7206 0.0128160215983 ko04071 Sphingolipid signaling pathway 23/603 162/7206 0.0135172639916 ko04145 Phagosome 23/603 162/7206 0.0135172639916 ko00190 Oxidative phosphorylation 19/603 127/7206 0.0137295494815 ko04978 Mineral absorption 8/603 40/7206 0.0160340101525 ko04742 Taste transduction 11/603 61/7206 0.016083644452 ko05161 Hepatitis B 6/603 173/7206 0.0170368030863 ko04668 TNF signaling pathway 3/603 120/7206 0.0181053582424 ko04960 Aldosterone-regulated sodium reabsorption 8/603 41/7206 0.0185088283296 ko05323 Rheumatoid arthritis 14/603 89/7206 0.0189460865134 ko04612 Antigen processing and presentation 1/603 77/7206 0.0201475288642 ko04973 Carbohydrate digestion and absorption 8/603 42/7206 0.0212453406744 ko05166 HTLV-I infection 14/603 292/7206 0.0229445114647 ko04064 NF-kappa B signaling pathway 2/603 96/7206 0.0235330489024 ko05215 Prostate cancer 3/603 111/7206 0.0240154210472 ko00512 Mucin type O-glycan biosynthesis 6/603 29/7206 0.0301960260328 ko00533 Glycosaminoglycan biosynthesis - keratan sulfate 4/603 15/7206 0.0314646003094 ko04750 Inflammatory mediator regulation of TRP channels 17/603 122/7206 0.0315315102411 ko05222 Small cell lung cancer 2/603 89/7206 0.032290765516 ko04922 Glucagon signaling pathway 18/603 128/7206 0.0340133489346 ko04540 Gap junction 18/603 128/7206 0.0340133489346 ko00290 Valine, leucine and isoleucine biosynthesis 2/603 4/7206 0.03742989112 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 12/603 79/7206 0.0383261841204 ko05200 Pathways in cancer 29/603 492/7206 0.0424816646607 ko04141 Protein processing in endoplasmic reticulum 8/603 184/7206 0.0429941515509 ko04350 TGF-beta signaling pathway 3/603 103/7206 0.0462966129729