ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	194/1179	423/7206	2.39348935821e-49
ko04724	Glutamatergic synapse	85/1179	152/7206	2.17554901812e-29
ko05033	Nicotine addiction	47/1179	56/7206	8.57150431125e-29
ko04713	Circadian entrainment	75/1179	136/7206	1.6443220474e-25
ko04721	Synaptic vesicle cycle	54/1179	80/7206	1.22211628575e-24
ko05032	Morphine addiction	63/1179	110/7206	8.53032770441e-23
ko04727	GABAergic synapse	62/1179	110/7206	6.03042948873e-22
ko04728	Dopaminergic synapse	85/1179	185/7206	1.1046900688e-21
ko04725	Cholinergic synapse	76/1179	160/7206	1.42771960273e-20
ko04742	Taste transduction	39/1179	61/7206	6.95843677931e-17
ko04723	Retrograde endocannabinoid signaling	74/1179	175/7206	1.62219637824e-16
ko04911	Insulin secretion	57/1179	117/7206	2.40875722363e-16
ko04024	cAMP signaling pathway	100/1179	279/7206	9.74526197371e-16
ko04726	Serotonergic synapse	60/1179	137/7206	1.90115602112e-14
ko04921	Oxytocin signaling pathway	79/1179	209/7206	2.98241969224e-14
ko04020	Calcium signaling pathway	93/1179	265/7206	3.26472959963e-14
ko05031	Amphetamine addiction	43/1179	91/7206	4.51806457394e-12
ko04261	Adrenergic signaling in cardiomyocytes	73/1179	205/7206	9.44241251976e-12
ko04740	Olfactory transduction	39/1179	80/7206	1.34093949571e-11
ko04744	Phototransduction	24/1179	36/7206	1.86396964901e-11
ko04720	Long-term potentiation	44/1179	99/7206	3.38020126082e-11
ko04970	Salivary secretion	42/1179	95/7206	1.168631077e-10
ko03040	Spliceosome	1/1179	145/7206	1.9372053751e-10
ko05168	Herpes simplex infection	5/1179	182/7206	5.43844871525e-09
ko05203	Viral carcinogenesis	14/1179	277/7206	6.67236781187e-09
ko04360	Axon guidance	73/1179	233/7206	7.84171513452e-09
ko04925	Aldosterone synthesis and secretion	40/1179	105/7206	6.3480278033e-08
ko04971	Gastric acid secretion	38/1179	98/7206	9.28934684256e-08
ko05030	Cocaine addiction	31/1179	73/7206	1.01040516624e-07
ko04966	Collecting duct acid secretion	16/1179	26/7206	2.4761279607e-07
ko03013	RNA transport	6/1179	166/7206	3.50649088856e-07
ko04120	Ubiquitin mediated proteolysis	4/1179	138/7206	6.29771084997e-07
ko04060	Cytokine-cytokine receptor interaction	9/1179	191/7206	8.24877211517e-07
ko04260	Cardiac muscle contraction	36/1179	98/7206	1.19482793264e-06
ko05164	Influenza A	7/1179	167/7206	1.29164175344e-06
ko04540	Gap junction	43/1179	128/7206	1.40131786618e-06
ko04924	Renin secretion	32/1179	86/7206	2.41097669754e-06
ko04022	cGMP-PKG signaling pathway	62/1179	216/7206	3.62345358324e-06
ko04621	NOD-like receptor signaling pathway	7/1179	157/7206	5.51643509917e-06
ko04745	Phototransduction - fly	18/1179	38/7206	7.78459736263e-06
ko04010	MAPK signaling pathway	83/1179	321/7206	9.25288730612e-06
ko04141	Protein processing in endoplasmic reticulum	10/1179	184/7206	1.04971994092e-05
ko04964	Proximal tubule bicarbonate reclamation	15/1179	29/7206	1.17000085001e-05
ko04514	Cell adhesion molecules (CAMs)	41/1179	130/7206	1.89630454261e-05
ko04610	Complement and coagulation cascades	1/1179	79/7206	2.03373198353e-05
ko05169	Epstein-Barr virus infection	13/1179	206/7206	2.08457985469e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	27/1179	74/7206	2.23709300662e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	23/1179	59/7206	2.46359753369e-05
ko04730	Long-term depression	28/1179	78/7206	3.41830151699e-05
ko05110	Vibrio cholerae infection	24/1179	63/7206	3.81680335462e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1179	79/7206	3.85532446271e-05
ko04976	Bile secretion	28/1179	80/7206	4.50138776863e-05
ko05322	Systemic lupus erythematosus	8/1179	151/7206	4.97925849214e-05
ko04110	Cell cycle	8/1179	145/7206	9.7728261905e-05
ko04972	Pancreatic secretion	34/1179	111/7206	0.000146354685963
ko03008	Ribosome biogenesis in eukaryotes	2/1179	79/7206	0.000171834110392
ko05162	Measles	6/1179	120/7206	0.000247388456417
ko04014	Ras signaling pathway	69/1179	279/7206	0.000258344426052
ko05140	Leishmaniasis	2/1179	75/7206	0.000398192966705
ko04064	NF-kappa B signaling pathway	4/1179	96/7206	0.000407459463057
ko04214	Apoptosis - fly	2/1179	72/7206	0.000574771494004
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1179	14/7206	0.000595293265778
ko04626	Plant-pathogen interaction	9/1179	18/7206	0.000969074371819
ko00240	Pyrimidine metabolism	6/1179	110/7206	0.00098591579493
ko05414	Dilated cardiomyopathy	32/1179	112/7206	0.0011053227445
ko04915	Estrogen signaling pathway	36/1179	131/7206	0.00115052042296
ko04750	Inflammatory mediator regulation of TRP channels	34/1179	122/7206	0.0011837274752
ko04146	Peroxisome	4/1179	89/7206	0.00124161275103
ko00480	Glutathione metabolism	1/1179	55/7206	0.0013667975679
ko04612	Antigen processing and presentation	3/1179	77/7206	0.00157704099912
ko03018	RNA degradation	4/1179	84/7206	0.0016915095645
ko05161	Hepatitis B	14/1179	173/7206	0.00173112999491
ko04640	Hematopoietic cell lineage	2/1179	64/7206	0.00182363493695
ko00590	Arachidonic acid metabolism	1/1179	52/7206	0.00200277839646
ko04916	Melanogenesis	37/1179	142/7206	0.00274066038881
ko00260	Glycine, serine and threonine metabolism	1/1179	48/7206	0.00293702742578
ko04371	Apelin signaling pathway	44/1179	177/7206	0.003717275449
ko03420	Nucleotide excision repair	1/1179	46/7206	0.00441431502652
ko04657	IL-17 signaling pathway	5/1179	87/7206	0.0050424825686
ko05321	Inflammatory bowel disease (IBD)	2/1179	56/7206	0.00571790936814
ko05166	HTLV-I infection	31/1179	292/7206	0.00588628162909
ko03022	Basal transcription factors	1/1179	44/7206	0.00669353862218
ko01524	Platinum drug resistance	4/1179	76/7206	0.0071380665744
ko01200	Carbon metabolism	10/1179	128/7206	0.00747829804457
ko05418	Fluid shear stress and atherosclerosis	16/1179	173/7206	0.00900157736602
ko04622	RIG-I-like receptor signaling pathway	3/1179	62/7206	0.00922078825418
ko04912	GnRH signaling pathway	31/1179	122/7206	0.00923064853045
ko05205	Proteoglycans in cancer	29/1179	271/7206	0.00927177651594
ko00561	Glycerolipid metabolism	3/1179	63/7206	0.00931514707846
ko04070	Phosphatidylinositol signaling system	29/1179	112/7206	0.00947003245537
ko04978	Mineral absorption	13/1179	40/7206	0.00966411254163
ko05131	Shigellosis	5/1179	82/7206	0.00980500850076
ko00310	Lysine degradation	4/1179	73/7206	0.0098847932297
ko04072	Phospholipase D signaling pathway	46/1179	197/7206	0.010728247578
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1179	100/7206	0.0134792674087
ko00330	Arginine and proline metabolism	3/1179	61/7206	0.0135051608289
ko04930	Type II diabetes mellitus	16/1179	54/7206	0.0146249449758
ko04932	Non-alcoholic fatty liver disease (NAFLD)	18/1179	182/7206	0.0146915511896
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1179	40/7206	0.0157361763653
ko04668	TNF signaling pathway	10/1179	120/7206	0.0172091172518
ko05145	Toxoplasmosis	11/1179	126/7206	0.0201523411196
ko04620	Toll-like receptor signaling pathway	8/1179	100/7206	0.0202077072462
ko04922	Glucagon signaling pathway	31/1179	128/7206	0.0212434096486
ko00982	Drug metabolism - cytochrome P450	1/1179	37/7206	0.0229072921213
ko04630	Jak-STAT signaling pathway	12/1179	132/7206	0.0232783023923
ko04217	Necroptosis	18/1179	178/7206	0.0234195996134
ko05144	Malaria	2/1179	45/7206	0.0254118716511
ko00071	Fatty acid degradation	2/1179	45/7206	0.0254118716511
ko04115	p53 signaling pathway	5/1179	74/7206	0.0255102752487
ko04974	Protein digestion and absorption	24/1179	96/7206	0.0260267471893
ko00600	Sphingolipid metabolism	4/1179	63/7206	0.0261473011441
ko00280	Valine, leucine and isoleucine degradation	3/1179	54/7206	0.0264269199152
ko00270	Cysteine and methionine metabolism	2/1179	47/7206	0.0267451967641
ko04923	Regulation of lipolysis in adipocytes	20/1179	77/7206	0.0290929296871
ko04210	Apoptosis	19/1179	180/7206	0.0319274631598
ko05120	Epithelial cell signaling in Helicobacter pylori infection	23/1179	92/7206	0.0322430049241
ko04140	Autophagy - animal	17/1179	164/7206	0.032917486956
ko00500	Starch and sucrose metabolism	1/1179	35/7206	0.0350654975781
ko04270	Vascular smooth muscle contraction	35/1179	154/7206	0.0360893188609
ko00983	Drug metabolism - other enzymes	2/1179	42/7206	0.0367010779778
ko05133	Pertussis	7/1179	87/7206	0.0396645022921
ko05034	Alcoholism	51/1179	238/7206	0.0398578731654
ko05214	Glioma	20/1179	79/7206	0.0448457478199
ko04015	Rap1 signaling pathway	58/1179	278/7206	0.0467210932714
ko05340	Primary immunodeficiency	1/1179	30/7206	0.0492720554207
ko04136	Autophagy - other	1/1179	31/7206	0.0493517967146