ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	178/1121	423/7206	5.81157958436e-42
ko04724	Glutamatergic synapse	81/1121	152/7206	1.14294920425e-27
ko05033	Nicotine addiction	43/1121	56/7206	2.13991337146e-24
ko04721	Synaptic vesicle cycle	50/1121	80/7206	1.16487096727e-21
ko05032	Morphine addiction	60/1121	110/7206	1.92788213494e-21
ko04713	Circadian entrainment	68/1121	136/7206	2.54305845714e-21
ko04728	Dopaminergic synapse	80/1121	185/7206	7.3705738773e-20
ko04727	GABAergic synapse	58/1121	110/7206	8.40944251172e-20
ko04725	Cholinergic synapse	69/1121	160/7206	3.3940081074e-17
ko04911	Insulin secretion	56/1121	117/7206	1.18224952249e-16
ko04723	Retrograde endocannabinoid signaling	71/1121	175/7206	6.02503888705e-16
ko04024	cAMP signaling pathway	92/1121	279/7206	1.62351243822e-13
ko04921	Oxytocin signaling pathway	75/1121	209/7206	2.1138278365e-13
ko04742	Taste transduction	34/1121	61/7206	4.68379460809e-13
ko04020	Calcium signaling pathway	87/1121	265/7206	1.13017251268e-12
ko04726	Serotonergic synapse	54/1121	137/7206	7.95096068206e-12
ko03040	Spliceosome	1/1121	145/7206	8.34119726365e-10
ko05031	Amphetamine addiction	38/1121	91/7206	1.49790821061e-09
ko04261	Adrenergic signaling in cardiomyocytes	66/1121	205/7206	1.6937188623e-09
ko04360	Axon guidance	72/1121	233/7206	1.99189690244e-09
ko04970	Salivary secretion	38/1121	95/7206	6.38765872828e-09
ko04720	Long-term potentiation	39/1121	99/7206	6.74941608609e-09
ko04925	Aldosterone synthesis and secretion	40/1121	105/7206	1.34293923341e-08
ko05168	Herpes simplex infection	5/1121	182/7206	1.9958040491e-08
ko05203	Viral carcinogenesis	15/1121	277/7206	1.73221060399e-07
ko03013	RNA transport	5/1121	166/7206	2.04160711955e-07
ko05164	Influenza A	5/1121	167/7206	2.0610640418e-07
ko04010	MAPK signaling pathway	84/1121	321/7206	5.32776994735e-07
ko04971	Gastric acid secretion	35/1121	98/7206	7.31391288872e-07
ko04060	Cytokine-cytokine receptor interaction	8/1121	191/7206	8.04378580952e-07
ko04744	Phototransduction	18/1121	36/7206	1.37474048801e-06
ko05322	Systemic lupus erythematosus	5/1121	151/7206	2.02591637912e-06
ko04540	Gap junction	40/1121	128/7206	6.32477544439e-06
ko05030	Cocaine addiction	27/1121	73/7206	1.00106071033e-05
ko04514	Cell adhesion molecules (CAMs)	40/1121	130/7206	1.22256322126e-05
ko04120	Ubiquitin mediated proteolysis	5/1121	138/7206	1.3270152794e-05
ko04740	Olfactory transduction	28/1121	80/7206	1.48207938701e-05
ko04730	Long-term depression	27/1121	78/7206	2.60012656591e-05
ko04924	Renin secretion	29/1121	86/7206	2.91799768502e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1121	79/7206	3.29597193078e-05
ko04022	cGMP-PKG signaling pathway	57/1121	216/7206	3.3887629705e-05
ko04966	Collecting duct acid secretion	13/1121	26/7206	4.16176547439e-05
ko04972	Pancreatic secretion	34/1121	111/7206	5.37535349755e-05
ko03008	Ribosome biogenesis in eukaryotes	1/1121	79/7206	5.44792617484e-05
ko04260	Cardiac muscle contraction	31/1121	98/7206	5.77190447681e-05
ko04621	NOD-like receptor signaling pathway	8/1121	157/7206	7.6802261322e-05
ko04141	Protein processing in endoplasmic reticulum	11/1121	184/7206	7.94310044768e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	25/1121	74/7206	0.000127059953109
ko04961	Endocrine and other factor-regulated calcium reabsorption	21/1121	59/7206	0.000165892462708
ko04745	Phototransduction - fly	15/1121	38/7206	0.00030896302407
ko05110	Vibrio cholerae infection	21/1121	63/7206	0.000369136404591
ko04640	Hematopoietic cell lineage	1/1121	64/7206	0.00039684319154
ko05169	Epstein-Barr virus infection	15/1121	206/7206	0.000412807773957
ko04976	Bile secretion	25/1121	80/7206	0.000463636753518
ko05162	Measles	6/1121	120/7206	0.000513788912297
ko04014	Ras signaling pathway	65/1121	279/7206	0.00052150052056
ko05414	Dilated cardiomyopathy	31/1121	112/7206	0.000890726958077
ko04750	Inflammatory mediator regulation of TRP channels	33/1121	122/7206	0.000944638621833
ko04146	Peroxisome	4/1121	89/7206	0.00177006167553
ko00240	Pyrimidine metabolism	6/1121	110/7206	0.00200300199069
ko00480	Glutathione metabolism	1/1121	55/7206	0.00213690203609
ko04371	Apelin signaling pathway	43/1121	177/7206	0.00216649987089
ko04070	Phosphatidylinositol signaling system	30/1121	112/7206	0.00220515841079
ko04612	Antigen processing and presentation	3/1121	77/7206	0.00228250414701
ko04064	NF-kappa B signaling pathway	5/1121	96/7206	0.00265262821721
ko05205	Proteoglycans in cancer	25/1121	271/7206	0.00266801979505
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1121	14/7206	0.00271195716916
ko00561	Glycerolipid metabolism	2/1121	63/7206	0.00276873445795
ko04964	Proximal tubule bicarbonate reclamation	11/1121	29/7206	0.00283730375244
ko00590	Arachidonic acid metabolism	1/1121	52/7206	0.00314799528512
ko05140	Leishmaniasis	3/1121	75/7206	0.00335141881868
ko00330	Arginine and proline metabolism	2/1121	61/7206	0.00403973073499
ko04110	Cell cycle	11/1121	145/7206	0.00528206474448
ko05161	Hepatitis B	14/1121	173/7206	0.00543235525231
ko04217	Necroptosis	15/1121	178/7206	0.00624119216203
ko05144	Malaria	1/1121	45/7206	0.00688816015134
ko00071	Fatty acid degradation	1/1121	45/7206	0.00688816015134
ko03420	Nucleotide excision repair	1/1121	46/7206	0.00690678444085
ko04915	Estrogen signaling pathway	32/1121	131/7206	0.00713512236173
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1121	100/7206	0.00754640416878
ko04930	Type II diabetes mellitus	16/1121	54/7206	0.00758043891619
ko04630	Jak-STAT signaling pathway	10/1121	132/7206	0.00758314160118
ko05321	Inflammatory bowel disease (IBD)	2/1121	56/7206	0.0086265802288
ko04932	Non-alcoholic fatty liver disease (NAFLD)	16/1121	182/7206	0.00929390440325
ko04916	Melanogenesis	34/1121	142/7206	0.00951653126247
ko01524	Platinum drug resistance	4/1121	76/7206	0.0100262144584
ko03022	Basal transcription factors	1/1121	44/7206	0.010517329128
ko04668	TNF signaling pathway	9/1121	120/7206	0.0108635725482
ko04015	Rap1 signaling pathway	59/1121	278/7206	0.0110660424631
ko05215	Prostate cancer	8/1121	111/7206	0.011717180692
ko04072	Phospholipase D signaling pathway	44/1121	197/7206	0.012253071781
ko00280	Valine, leucine and isoleucine degradation	2/1121	54/7206	0.0127336215882
ko01200	Carbon metabolism	10/1121	128/7206	0.0132665852623
ko04622	RIG-I-like receptor signaling pathway	3/1121	62/7206	0.0135950862817
ko05131	Shigellosis	5/1121	82/7206	0.013700171078
ko03018	RNA degradation	5/1121	84/7206	0.0141958600222
ko04626	Plant-pathogen interaction	7/1121	18/7206	0.0142505686038
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1121	40/7206	0.0153141257159
ko00983	Drug metabolism - other enzymes	1/1121	42/7206	0.0161739436252
ko04620	Toll-like receptor signaling pathway	7/1121	100/7206	0.0171514811203
ko05145	Toxoplasmosis	10/1121	126/7206	0.0176287968369
ko04270	Vascular smooth muscle contraction	35/1121	154/7206	0.0177406127505
ko00380	Tryptophan metabolism	2/1121	50/7206	0.0180721562097
ko03320	PPAR signaling pathway	4/1121	69/7206	0.0193542740871
ko04658	Th1 and Th2 cell differentiation	7/1121	96/7206	0.0225807082745
ko00982	Drug metabolism - cytochrome P450	1/1121	37/7206	0.0228508658027
ko04657	IL-17 signaling pathway	6/1121	87/7206	0.0244473283878
ko05133	Pertussis	6/1121	87/7206	0.0244473283878
ko05166	HTLV-I infection	32/1121	292/7206	0.0259057630245
ko04391	Hippo signaling pathway - fly	22/1121	90/7206	0.0269417050176
ko04975	Fat digestion and absorption	1/1121	35/7206	0.0339061895778
ko00500	Starch and sucrose metabolism	1/1121	35/7206	0.0339061895778
ko00512	Mucin type O-glycan biosynthesis	9/1121	29/7206	0.0348284642147
ko00310	Lysine degradation	5/1121	73/7206	0.0350509391546
ko04115	p53 signaling pathway	5/1121	74/7206	0.0350965656996
ko00564	Glycerophospholipid metabolism	8/1121	99/7206	0.0361637458984
ko04216	Ferroptosis	2/1121	44/7206	0.0376238504567
ko04140	Autophagy - animal	16/1121	164/7206	0.03804244661
ko00620	Pyruvate metabolism	2/1121	46/7206	0.0383891183683
ko00562	Inositol phosphate metabolism	21/1121	89/7206	0.0397125116816
ko04214	Apoptosis - fly	5/1121	72/7206	0.0480209310852