ko pathway ratio_in_study ratio_in_pop p_value ko03040 Spliceosome 56/470 145/7206 5.98784174409e-30 ko04110 Cell cycle 52/470 145/7206 4.95354243559e-26 ko04111 Cell cycle - yeast 40/470 90/7206 2.215405361e-24 ko03030 DNA replication 22/470 38/7206 4.30299587916e-17 ko04113 Meiosis - yeast 25/470 70/7206 5.06348842524e-13 ko04080 Neuroactive ligand-receptor interaction 1/470 423/7206 8.57357443598e-12 ko03430 Mismatch repair 12/470 22/7206 1.83349091733e-09 ko03013 RNA transport 33/470 166/7206 5.17022821401e-09 ko03460 Fanconi anemia pathway 17/470 51/7206 9.78451674593e-09 ko03015 mRNA surveillance pathway 23/470 93/7206 1.62708147672e-08 ko03440 Homologous recombination 15/470 41/7206 1.72717313966e-08 ko05166 HTLV-I infection 43/470 292/7206 3.29402862623e-07 ko03410 Base excision repair 13/470 38/7206 3.9296093119e-07 ko04020 Calcium signaling pathway 2/470 265/7206 5.33464038215e-06 ko03008 Ribosome biogenesis in eukaryotes 17/470 79/7206 9.57950311587e-06 ko00240 Pyrimidine metabolism 20/470 110/7206 2.31926672967e-05 ko05217 Basal cell carcinoma 15/470 68/7206 2.34163298401e-05 ko03420 Nucleotide excision repair 12/470 46/7206 2.60221530054e-05 ko05010 Alzheimer's disease 1/470 202/7206 3.16390419929e-05 ko04310 Wnt signaling pathway 27/470 181/7206 4.41216807646e-05 ko05206 MicroRNAs in cancer 26/470 177/7206 7.77997284268e-05 ko04723 Retrograde endocannabinoid signaling 1/470 175/7206 0.000146486972376 ko04725 Cholinergic synapse 1/470 160/7206 0.000485086968363 ko04330 Notch signaling pathway 12/470 62/7206 0.00055538370095 ko04022 cGMP-PKG signaling pathway 3/470 216/7206 0.000625622331227 ko04932 Non-alcoholic fatty liver disease (NAFLD) 2/470 182/7206 0.000682517450113 ko04142 Lysosome 1/470 151/7206 0.000687318065455 ko04921 Oxytocin signaling pathway 3/470 209/7206 0.000878751603473 ko04713 Circadian entrainment 1/470 136/7206 0.00225506200353 ko05200 Pathways in cancer 49/470 492/7206 0.00237156098727 ko04060 Cytokine-cytokine receptor interaction 3/470 191/7206 0.00251760384264 ko05224 Breast cancer 22/470 174/7206 0.00263450249524 ko04514 Cell adhesion molecules (CAMs) 1/470 130/7206 0.00330123731089 ko04915 Estrogen signaling pathway 1/470 131/7206 0.00338057622746 ko04144 Endocytosis 10/470 342/7206 0.003397932607 ko04261 Adrenergic signaling in cardiomyocytes 4/470 205/7206 0.0037508696588 ko04270 Vascular smooth muscle contraction 2/470 154/7206 0.00427645612985 ko04120 Ubiquitin mediated proteolysis 18/470 138/7206 0.00446296602135 ko04114 Oocyte meiosis 18/470 139/7206 0.00469967621395 ko04371 Apelin signaling pathway 3/470 177/7206 0.00488416458916 ko04072 Phospholipase D signaling pathway 4/470 197/7206 0.00518453145712 ko04062 Chemokine signaling pathway 4/470 201/7206 0.00528482076531 ko00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin 6/470 26/7206 0.00559411679784 ko05202 Transcriptional misregulation in cancer 22/470 188/7206 0.00656244115471 ko04911 Insulin secretion 1/470 117/7206 0.00691143611327 ko04931 Insulin resistance 2/470 137/7206 0.00842272950449 ko04611 Platelet activation 3/470 163/7206 0.00944813310899 ko04140 Autophagy - animal 3/470 164/7206 0.00951836497698 ko04728 Dopaminergic synapse 4/470 185/7206 0.00984903778415 ko04972 Pancreatic secretion 1/470 111/7206 0.010073565315 ko05414 Dilated cardiomyopathy 1/470 112/7206 0.010271168071 ko04340 Hedgehog signaling pathway 9/470 58/7206 0.0120435476718 ko04621 NOD-like receptor signaling pathway 3/470 157/7206 0.0131828005478 ko04550 Signaling pathways regulating pluripotency of stem cells 19/470 165/7206 0.0152477922441 ko04910 Insulin signaling pathway 4/470 172/7206 0.0184571873129 ko04024 cAMP signaling pathway 9/470 279/7206 0.0185818221677 ko05160 Hepatitis C 3/470 153/7206 0.018733500527 ko04011 MAPK signaling pathway - yeast 8/470 53/7206 0.0204217209939 ko04650 Natural killer cell mediated cytotoxicity 1/470 97/7206 0.020732191008 ko00564 Glycerophospholipid metabolism 1/470 99/7206 0.0212961059103 ko05410 Hypertrophic cardiomyopathy (HCM) 1/470 100/7206 0.021716583679 ko04620 Toll-like receptor signaling pathway 1/470 100/7206 0.021716583679 ko04668 TNF signaling pathway 2/470 120/7206 0.0239097916431 ko04750 Inflammatory mediator regulation of TRP channels 2/470 122/7206 0.0242959452302 ko04914 Progesterone-mediated oocyte maturation 13/470 104/7206 0.0243369249179 ko00230 Purine metabolism 21/470 194/7206 0.0253272912901 ko00310 Lysine degradation 10/470 73/7206 0.026420906325 ko04115 p53 signaling pathway 10/470 74/7206 0.027722180442 ko04218 Cellular senescence 19/470 177/7206 0.0295665346969 ko05323 Rheumatoid arthritis 1/470 89/7206 0.0297108734349 ko05031 Amphetamine addiction 1/470 91/7206 0.0300427688613 ko04139 Mitophagy - yeast 6/470 37/7206 0.0308624972556 ko04390 Hippo signaling pathway 20/470 188/7206 0.0340951140943 ko04145 Phagosome 4/470 162/7206 0.0345411698196 ko04213 Longevity regulating pathway - multiple species 1/470 86/7206 0.0439810930694 ko04924 Renin secretion 1/470 86/7206 0.0439810930694 ko05133 Pertussis 1/470 87/7206 0.0446831933993 ko04151 PI3K-Akt signaling pathway 16/470 390/7206 0.045021001799 ko04380 Osteoclast differentiation 3/470 134/7206 0.0489409597263 ko05231 Choline metabolism in cancer 3/470 134/7206 0.0489409597263