ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04724	Glutamatergic synapse	62/667	152/7206	6.17644327043e-26
ko05033	Nicotine addiction	36/667	56/7206	3.38113504587e-24
ko04727	GABAergic synapse	50/667	110/7206	1.16610618186e-23
ko05032	Morphine addiction	49/667	110/7206	1.00694939581e-22
ko04080	Neuroactive ligand-receptor interaction	101/667	423/7206	2.17120132701e-20
ko04723	Retrograde endocannabinoid signaling	59/667	175/7206	8.37690523055e-20
ko04744	Phototransduction	26/667	36/7206	8.85576571217e-20
ko04713	Circadian entrainment	49/667	136/7206	5.51456599245e-18
ko04728	Dopaminergic synapse	56/667	185/7206	1.99851769505e-16
ko04721	Synaptic vesicle cycle	34/667	80/7206	2.355213606e-15
ko04725	Cholinergic synapse	45/667	160/7206	3.64643158345e-12
ko04726	Serotonergic synapse	39/667	137/7206	7.01187926737e-11
ko04024	cAMP signaling pathway	60/667	279/7206	2.5162783334e-10
ko04921	Oxytocin signaling pathway	49/667	209/7206	4.96136107834e-10
ko04742	Taste transduction	23/667	61/7206	1.47838673585e-09
ko04911	Insulin secretion	33/667	117/7206	2.73325054865e-09
ko04740	Olfactory transduction	25/667	80/7206	2.4890853342e-08
ko05031	Amphetamine addiction	25/667	91/7206	4.09068837191e-07
ko04261	Adrenergic signaling in cardiomyocytes	42/667	205/7206	5.52652898802e-07
ko05030	Cocaine addiction	21/667	73/7206	1.52560851983e-06
ko04020	Calcium signaling pathway	49/667	265/7206	2.13581636849e-06
ko05203	Viral carcinogenesis	6/667	277/7206	2.26544223591e-06
ko05164	Influenza A	1/667	167/7206	2.32371019632e-06
ko04010	MAPK signaling pathway	56/667	321/7206	2.53462143411e-06
ko04720	Long-term potentiation	24/667	99/7206	7.76704970998e-06
ko05322	Systemic lupus erythematosus	1/667	151/7206	1.17363327964e-05
ko04970	Salivary secretion	23/667	95/7206	1.2268653332e-05
ko03040	Spliceosome	1/667	145/7206	1.71517986423e-05
ko04060	Cytokine-cytokine receptor interaction	3/667	191/7206	2.01422878153e-05
ko05169	Epstein-Barr virus infection	4/667	206/7206	2.6171427869e-05
ko04120	Ubiquitin mediated proteolysis	1/667	138/7206	3.86028363721e-05
ko04966	Collecting duct acid secretion	10/667	26/7206	5.8065685683e-05
ko04260	Cardiac muscle contraction	22/667	98/7206	6.57564942419e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	18/667	74/7206	0.000100524967181
ko05215	Prostate cancer	1/667	111/7206	0.000404429994167
ko03013	RNA transport	4/667	166/7206	0.000626837842111
ko04730	Long-term depression	17/667	78/7206	0.000627343589135
ko04972	Pancreatic secretion	22/667	111/7206	0.000680813848694
ko04110	Cell cycle	3/667	145/7206	0.000758794571755
ko04350	TGF-beta signaling pathway	1/667	103/7206	0.000887520928622
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	17/667	79/7206	0.00117730070238
ko05205	Proteoglycans in cancer	11/667	271/7206	0.00128503146027
ko04022	cGMP-PKG signaling pathway	34/667	216/7206	0.00179067212719
ko04745	Phototransduction - fly	10/667	38/7206	0.00185893692698
ko05166	HTLV-I infection	13/667	292/7206	0.00260713286179
ko04141	Protein processing in endoplasmic reticulum	6/667	184/7206	0.00270701629461
ko04925	Aldosterone synthesis and secretion	19/667	105/7206	0.00361909147277
ko04964	Proximal tubule bicarbonate reclamation	8/667	29/7206	0.00382113197905
ko05218	Melanoma	1/667	85/7206	0.0041437645197
ko04971	Gastric acid secretion	18/667	98/7206	0.00421312258065
ko04810	Regulation of actin cytoskeleton	12/667	264/7206	0.00475633276669
ko04621	NOD-like receptor signaling pathway	5/667	157/7206	0.00492383768197
ko05161	Hepatitis B	6/667	173/7206	0.00493064649522
ko04710	Circadian rhythm	10/667	43/7206	0.00494160697686
ko05034	Alcoholism	35/667	238/7206	0.00591663239617
ko04014	Ras signaling pathway	39/667	279/7206	0.00816023119179
ko04510	Focal adhesion	11/667	240/7206	0.00878786668278
ko04612	Antigen processing and presentation	1/667	77/7206	0.00896160975887
ko04550	Signaling pathways regulating pluripotency of stem cells	6/667	165/7206	0.0091322325688
ko04630	Jak-STAT signaling pathway	4/667	132/7206	0.0091689480839
ko04961	Endocrine and other factor-regulated calcium reabsorption	12/667	59/7206	0.0100527417599
ko05224	Breast cancer	7/667	174/7206	0.0116102459307
ko04072	Phospholipase D signaling pathway	29/667	197/7206	0.0119451342812
ko00830	Retinol metabolism	9/667	42/7206	0.0130057928517
ko00310	Lysine degradation	1/667	73/7206	0.0131736751205
ko04514	Cell adhesion molecules (CAMs)	21/667	130/7206	0.0132184511743
ko04924	Renin secretion	15/667	86/7206	0.0138875805117
ko04062	Chemokine signaling pathway	29/667	201/7206	0.0180626307579
ko05168	Herpes simplex infection	8/667	182/7206	0.019076021335
ko04932	Non-alcoholic fatty liver disease (NAFLD)	8/667	182/7206	0.019076021335
ko04540	Gap junction	20/667	128/7206	0.0195273978935
ko05414	Dilated cardiomyopathy	18/667	112/7206	0.0197642983706
ko03018	RNA degradation	2/667	84/7206	0.0221820375961
ko05206	MicroRNAs in cancer	8/667	177/7206	0.0249666651763
ko04218	Cellular senescence	8/667	177/7206	0.0249666651763
ko04711	Circadian rhythm - fly	4/667	13/7206	0.0264005091945
ko04140	Autophagy - animal	7/667	164/7206	0.0277817272352
ko05016	Huntington's disease	11/667	215/7206	0.0311304316389
ko04610	Complement and coagulation cascades	2/667	79/7206	0.0313878199817
ko04064	NF-kappa B signaling pathway	3/667	96/7206	0.0324999409068
ko04910	Insulin signaling pathway	8/667	172/7206	0.0325496288688
ko04918	Thyroid hormone synthesis	14/667	86/7206	0.0364368486271
ko00330	Arginine and proline metabolism	1/667	61/7206	0.0416635051183
ko05145	Toxoplasmosis	5/667	126/7206	0.0418827685932
ko05140	Leishmaniasis	2/667	75/7206	0.044286059494
ko05110	Vibrio cholerae infection	11/667	63/7206	0.0443140348994
ko01524	Platinum drug resistance	2/667	76/7206	0.0445347992247
ko04070	Phosphatidylinositol signaling system	17/667	112/7206	0.0459175838016
ko04976	Bile secretion	13/667	80/7206	0.0483845051843
ko04210	Apoptosis	9/667	180/7206	0.0495181941756