ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	200/1202	423/7206	3.66428951927e-52
ko04724	Glutamatergic synapse	91/1202	152/7206	5.89758173991e-34
ko05033	Nicotine addiction	49/1202	56/7206	2.35208749412e-31
ko05032	Morphine addiction	69/1202	110/7206	1.03932906027e-27
ko04713	Circadian entrainment	78/1202	136/7206	1.84548405906e-27
ko04727	GABAergic synapse	68/1202	110/7206	9.02363329211e-27
ko04721	Synaptic vesicle cycle	55/1202	80/7206	2.90979843848e-25
ko04725	Cholinergic synapse	78/1202	160/7206	1.96129451629e-21
ko04728	Dopaminergic synapse	85/1202	185/7206	4.15304770057e-21
ko04723	Retrograde endocannabinoid signaling	80/1202	175/7206	9.35481566603e-20
ko04024	cAMP signaling pathway	105/1202	279/7206	8.34566495854e-18
ko04020	Calcium signaling pathway	100/1202	265/7206	4.96166642796e-17
ko04921	Oxytocin signaling pathway	84/1202	209/7206	2.03460320348e-16
ko04742	Taste transduction	38/1202	61/7206	1.21252093247e-15
ko04726	Serotonergic synapse	61/1202	137/7206	1.1266889369e-14
ko04911	Insulin secretion	55/1202	117/7206	1.37241710291e-14
ko04720	Long-term potentiation	48/1202	99/7206	1.56517911484e-13
ko04261	Adrenergic signaling in cardiomyocytes	76/1202	205/7206	1.23764755532e-12
ko05031	Amphetamine addiction	44/1202	91/7206	1.84861306811e-12
ko04744	Phototransduction	25/1202	36/7206	2.65672421466e-12
ko04970	Salivary secretion	44/1202	95/7206	1.18226712467e-11
ko03040	Spliceosome	1/1202	145/7206	1.17408591815e-10
ko04740	Olfactory transduction	38/1202	80/7206	1.19387213526e-10
ko05168	Herpes simplex infection	6/1202	182/7206	1.55312685465e-08
ko04360	Axon guidance	73/1202	233/7206	1.83817170833e-08
ko04022	cGMP-PKG signaling pathway	69/1202	216/7206	2.40444415342e-08
ko04060	Cytokine-cytokine receptor interaction	7/1202	191/7206	3.11961103253e-08
ko04925	Aldosterone synthesis and secretion	41/1202	105/7206	3.427851807e-08
ko04971	Gastric acid secretion	38/1202	98/7206	1.35070873829e-07
ko05203	Viral carcinogenesis	17/1202	277/7206	1.55879609922e-07
ko05030	Cocaine addiction	30/1202	73/7206	5.94373005527e-07
ko03013	RNA transport	7/1202	166/7206	8.62579348952e-07
ko04540	Gap junction	44/1202	128/7206	8.90579523821e-07
ko04010	MAPK signaling pathway	87/1202	321/7206	1.62902108414e-06
ko04745	Phototransduction - fly	19/1202	38/7206	2.09238322144e-06
ko04966	Collecting duct acid secretion	15/1202	26/7206	2.44882284457e-06
ko04924	Renin secretion	32/1202	86/7206	3.54715355326e-06
ko04730	Long-term depression	30/1202	78/7206	3.7217713385e-06
ko04260	Cardiac muscle contraction	35/1202	98/7206	3.89760270551e-06
ko05322	Systemic lupus erythematosus	7/1202	151/7206	7.62650909933e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1202	74/7206	1.08143637167e-05
ko04120	Ubiquitin mediated proteolysis	6/1202	138/7206	1.39225891019e-05
ko04070	Phosphatidylinositol signaling system	37/1202	112/7206	1.75555365053e-05
ko04371	Apelin signaling pathway	52/1202	177/7206	2.18841292872e-05
ko04110	Cell cycle	7/1202	145/7206	2.28028249239e-05
ko04014	Ras signaling pathway	73/1202	279/7206	3.85378045079e-05
ko05110	Vibrio cholerae infection	24/1202	63/7206	4.55980919612e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1202	79/7206	4.76590373333e-05
ko05164	Influenza A	10/1202	167/7206	5.26675392869e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	23/1202	59/7206	5.40157910545e-05
ko04072	Phospholipase D signaling pathway	55/1202	197/7206	5.97543968385e-05
ko04972	Pancreatic secretion	35/1202	111/7206	9.28939037597e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1202	79/7206	0.000111343867541
ko05414	Dilated cardiomyopathy	35/1202	112/7206	0.000160112933544
ko04612	Antigen processing and presentation	2/1202	77/7206	0.000165844415628
ko04141	Protein processing in endoplasmic reticulum	13/1202	184/7206	0.000179848935019
ko04626	Plant-pathogen interaction	10/1202	18/7206	0.000193015373996
ko04621	NOD-like receptor signaling pathway	10/1202	157/7206	0.000194693112127
ko04915	Estrogen signaling pathway	39/1202	131/7206	0.000196154675737
ko05169	Epstein-Barr virus infection	16/1202	206/7206	0.000201551980886
ko05140	Leishmaniasis	2/1202	75/7206	0.000248918662611
ko04064	NF-kappa B signaling pathway	4/1202	96/7206	0.000271134184852
ko04750	Inflammatory mediator regulation of TRP channels	36/1202	122/7206	0.000335990010163
ko04976	Bile secretion	26/1202	80/7206	0.000426514376981
ko05162	Measles	7/1202	120/7206	0.000493243529457
ko04514	Cell adhesion molecules (CAMs)	37/1202	130/7206	0.000761132009185
ko04146	Peroxisome	4/1202	89/7206	0.000820470578331
ko00520	Amino sugar and nucleotide sugar metabolism	1/1202	55/7206	0.000838288378096
ko00480	Glutathione metabolism	1/1202	55/7206	0.000838288378096
ko05205	Proteoglycans in cancer	26/1202	271/7206	0.000862867000915
ko04922	Glucagon signaling pathway	36/1202	128/7206	0.00108771858678
ko00590	Arachidonic acid metabolism	1/1202	52/7206	0.00126906066466
ko04923	Regulation of lipolysis in adipocytes	24/1202	77/7206	0.0017242730101
ko00240	Pyrimidine metabolism	7/1202	110/7206	0.00183249324317
ko04214	Apoptosis - fly	3/1202	72/7206	0.00214828805042
ko00310	Lysine degradation	3/1202	73/7206	0.00223567901296
ko05161	Hepatitis B	15/1202	173/7206	0.00269681461888
ko04912	GnRH signaling pathway	33/1202	122/7206	0.00317186622621
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1202	14/7206	0.00409042476353
ko05144	Malaria	1/1202	45/7206	0.00434015070823
ko00071	Fatty acid degradation	1/1202	45/7206	0.00434015070823
ko03420	Nucleotide excision repair	1/1202	46/7206	0.00444282643432
ko04964	Proximal tubule bicarbonate reclamation	11/1202	29/7206	0.0049625976289
ko05321	Inflammatory bowel disease (IBD)	2/1202	56/7206	0.00585548721382
ko00562	Inositol phosphate metabolism	25/1202	89/7206	0.00613426873249
ko05166	HTLV-I infection	32/1202	292/7206	0.00632014130238
ko04640	Hematopoietic cell lineage	3/1202	64/7206	0.00637478762987
ko03022	Basal transcription factors	1/1202	44/7206	0.00684115835769
ko04622	RIG-I-like receptor signaling pathway	3/1202	62/7206	0.00923295990359
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1202	100/7206	0.00951205671355
ko05231	Choline metabolism in cancer	34/1202	134/7206	0.0096360616983
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1202	40/7206	0.00979326433952
ko00140	Steroid hormone biosynthesis	1/1202	41/7206	0.0100028661293
ko04350	TGF-beta signaling pathway	8/1202	103/7206	0.0112056239382
ko04270	Vascular smooth muscle contraction	38/1202	154/7206	0.0114382736934
ko04658	Th1 and Th2 cell differentiation	7/1202	96/7206	0.0122408695677
ko04657	IL-17 signaling pathway	6/1202	87/7206	0.0129280510728
ko01524	Platinum drug resistance	5/1202	76/7206	0.0131347647946
ko04015	Rap1 signaling pathway	62/1202	278/7206	0.013580116591
ko00982	Drug metabolism - cytochrome P450	1/1202	37/7206	0.0147187937474
ko00630	Glyoxylate and dicarboxylate metabolism	1/1202	38/7206	0.0147577787652
ko03410	Base excision repair	1/1202	38/7206	0.0147577787652
ko05145	Toxoplasmosis	11/1202	126/7206	0.015231199438
ko05010	Alzheimer's disease	47/1202	202/7206	0.0162301282746
ko04916	Melanogenesis	35/1202	142/7206	0.0162720013683
ko03018	RNA degradation	6/1202	84/7206	0.0174459585195
ko00260	Glycine, serine and threonine metabolism	2/1202	48/7206	0.01778024374
ko04630	Jak-STAT signaling pathway	12/1202	132/7206	0.0177931273679
ko04115	p53 signaling pathway	5/1202	74/7206	0.0180879527206
ko05034	Alcoholism	53/1202	238/7206	0.021465058126
ko05214	Glioma	21/1202	79/7206	0.0225058188856
ko05120	Epithelial cell signaling in Helicobacter pylori infection	24/1202	92/7206	0.0230708243562
ko05131	Shigellosis	6/1202	82/7206	0.024012432744
ko04668	TNF signaling pathway	11/1202	120/7206	0.0255735105867
ko00010	Glycolysis / Gluconeogenesis	20/1202	74/7206	0.026504194562
ko04114	Oocyte meiosis	33/1202	139/7206	0.028771204167
ko05133	Pertussis	7/1202	87/7206	0.0291148390478
ko04722	Neurotrophin signaling pathway	37/1202	160/7206	0.0316939933301
ko04217	Necroptosis	19/1202	178/7206	0.0318829723794
ko05217	Basal cell carcinoma	5/1202	68/7206	0.0339347972338
ko03320	PPAR signaling pathway	5/1202	69/7206	0.0339465761647
ko05230	Central carbon metabolism in cancer	21/1202	81/7206	0.0344010397709
ko00983	Drug metabolism - other enzymes	2/1202	42/7206	0.0364038072701
ko00330	Arginine and proline metabolism	4/1202	61/7206	0.0364691406418
ko04918	Thyroid hormone synthesis	22/1202	86/7206	0.0399419825126
ko04930	Type II diabetes mellitus	15/1202	54/7206	0.0412742327528
ko04620	Toll-like receptor signaling pathway	9/1202	100/7206	0.0415928692418
ko00512	Mucin type O-glycan biosynthesis	9/1202	29/7206	0.0461520193779