ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	202/1216	423/7206	1.02201193126e-52
ko04724	Glutamatergic synapse	89/1216	152/7206	8.96603552888e-32
ko04713	Circadian entrainment	78/1216	136/7206	4.10560036669e-27
ko05033	Nicotine addiction	46/1216	56/7206	8.62333851159e-27
ko05032	Morphine addiction	68/1216	110/7206	1.84206656926e-26
ko04727	GABAergic synapse	65/1216	110/7206	9.14588512057e-24
ko04721	Synaptic vesicle cycle	52/1216	80/7206	5.79626713045e-22
ko04728	Dopaminergic synapse	86/1216	185/7206	2.02780424791e-21
ko04020	Calcium signaling pathway	107/1216	265/7206	2.84943058054e-20
ko04725	Cholinergic synapse	76/1216	160/7206	9.68386249756e-20
ko04723	Retrograde endocannabinoid signaling	77/1216	175/7206	1.50173849373e-17
ko04024	cAMP signaling pathway	104/1216	279/7206	6.31280287762e-17
ko04911	Insulin secretion	58/1216	117/7206	2.04173903643e-16
ko04921	Oxytocin signaling pathway	83/1216	209/7206	1.75001993714e-15
ko04742	Taste transduction	38/1216	61/7206	1.79976478231e-15
ko04726	Serotonergic synapse	62/1216	137/7206	4.633715258e-15
ko04970	Salivary secretion	47/1216	95/7206	1.68341592453e-13
ko04720	Long-term potentiation	45/1216	99/7206	2.3159239517e-11
ko05031	Amphetamine addiction	42/1216	91/7206	5.89751420869e-11
ko04261	Adrenergic signaling in cardiomyocytes	73/1216	205/7206	6.46872823958e-11
ko03040	Spliceosome	1/1216	145/7206	1.23203561012e-10
ko04360	Axon guidance	76/1216	233/7206	2.16052599037e-09
ko04022	cGMP-PKG signaling pathway	71/1216	216/7206	5.27965589694e-09
ko04925	Aldosterone synthesis and secretion	42/1216	105/7206	1.57820268567e-08
ko04744	Phototransduction	21/1216	36/7206	2.14405375379e-08
ko05203	Viral carcinogenesis	16/1216	277/7206	2.75861640629e-08
ko04740	Olfactory transduction	34/1216	80/7206	5.25432608119e-08
ko04971	Gastric acid secretion	39/1216	98/7206	6.11565822267e-08
ko04540	Gap junction	46/1216	128/7206	1.40758996771e-07
ko05164	Influenza A	6/1216	167/7206	1.5869776627e-07
ko05168	Herpes simplex infection	8/1216	182/7206	3.30161261424e-07
ko04060	Cytokine-cytokine receptor interaction	9/1216	191/7206	3.78769697302e-07
ko04924	Renin secretion	34/1216	86/7206	5.40354030925e-07
ko03013	RNA transport	7/1216	166/7206	8.63580456433e-07
ko04730	Long-term depression	31/1216	78/7206	1.7076795123e-06
ko04120	Ubiquitin mediated proteolysis	5/1216	138/7206	2.64541756459e-06
ko04966	Collecting duct acid secretion	15/1216	26/7206	2.8483680396e-06
ko05322	Systemic lupus erythematosus	7/1216	151/7206	7.69623024233e-06
ko04972	Pancreatic secretion	38/1216	111/7206	8.27184023811e-06
ko04010	MAPK signaling pathway	85/1216	321/7206	8.5497782796e-06
ko05030	Cocaine addiction	28/1216	73/7206	1.01272731586e-05
ko04621	NOD-like receptor signaling pathway	8/1216	157/7206	1.19650679684e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	24/1216	59/7206	1.20005872365e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1216	74/7206	1.30364526232e-05
ko04141	Protein processing in endoplasmic reticulum	11/1216	184/7206	1.39834211209e-05
ko04514	Cell adhesion molecules (CAMs)	42/1216	130/7206	1.41922730631e-05
ko04964	Proximal tubule bicarbonate reclamation	15/1216	29/7206	1.723411194e-05
ko05169	Epstein-Barr virus infection	14/1216	206/7206	2.6680003382e-05
ko04976	Bile secretion	29/1216	80/7206	2.79764077326e-05
ko04745	Phototransduction - fly	17/1216	38/7206	5.33676217725e-05
ko04260	Cardiac muscle contraction	33/1216	98/7206	5.39069765835e-05
ko04070	Phosphatidylinositol signaling system	36/1216	112/7206	6.09947519037e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1216	79/7206	0.00011009263244
ko05110	Vibrio cholerae infection	23/1216	63/7206	0.00014309448961
ko04110	Cell cycle	9/1216	145/7206	0.000186840194138
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1216	79/7206	0.000195841848015
ko04750	Inflammatory mediator regulation of TRP channels	37/1216	122/7206	0.000207207292551
ko04014	Ras signaling pathway	71/1216	279/7206	0.000222550596463
ko04371	Apelin signaling pathway	49/1216	177/7206	0.000234668649199
ko05162	Measles	7/1216	120/7206	0.000490426031832
ko04146	Peroxisome	4/1216	89/7206	0.000556344999367
ko05414	Dilated cardiomyopathy	33/1216	112/7206	0.000822200172269
ko04064	NF-kappa B signaling pathway	5/1216	96/7206	0.000875525882606
ko05140	Leishmaniasis	3/1216	75/7206	0.000998908735389
ko04612	Antigen processing and presentation	3/1216	77/7206	0.00104243069869
ko00330	Arginine and proline metabolism	2/1216	61/7206	0.00174144693948
ko04072	Phospholipase D signaling pathway	50/1216	197/7206	0.00195696905058
ko04610	Complement and coagulation cascades	4/1216	79/7206	0.00234017119567
ko05161	Hepatitis B	15/1216	173/7206	0.00269461056201
ko05205	Proteoglycans in cancer	28/1216	271/7206	0.00279792980047
ko05166	HTLV-I infection	31/1216	292/7206	0.00304486692013
ko04217	Necroptosis	16/1216	178/7206	0.00315929224403
ko04657	IL-17 signaling pathway	5/1216	87/7206	0.00352118892458
ko05321	Inflammatory bowel disease (IBD)	2/1216	56/7206	0.00377685923338
ko03022	Basal transcription factors	1/1216	44/7206	0.00431102329269
ko00071	Fatty acid degradation	1/1216	45/7206	0.00432810474661
ko00240	Pyrimidine metabolism	8/1216	110/7206	0.00452157422986
ko03420	Nucleotide excision repair	1/1216	46/7206	0.00452382656709
ko03018	RNA degradation	5/1216	84/7206	0.00488048048761
ko01524	Platinum drug resistance	4/1216	76/7206	0.00488547055664
ko04923	Regulation of lipolysis in adipocytes	23/1216	77/7206	0.00514574905681
ko05145	Toxoplasmosis	10/1216	126/7206	0.00541308588405
ko00480	Glutathione metabolism	2/1216	55/7206	0.0057008117882
ko04626	Plant-pathogen interaction	8/1216	18/7206	0.00571081856387
ko04922	Glucagon signaling pathway	34/1216	128/7206	0.00573191005841
ko04640	Hematopoietic cell lineage	3/1216	64/7206	0.0064275716849
ko04270	Vascular smooth muscle contraction	39/1216	154/7206	0.00643978692159
ko04630	Jak-STAT signaling pathway	11/1216	132/7206	0.00661743351214
ko04214	Apoptosis - fly	4/1216	72/7206	0.00667343149856
ko00590	Arachidonic acid metabolism	2/1216	52/7206	0.00819826227467
ko04930	Type II diabetes mellitus	17/1216	54/7206	0.00914753383986
ko05133	Pertussis	6/1216	87/7206	0.00916223118418
ko04330	Notch signaling pathway	3/1216	62/7206	0.00939459994149
ko04622	RIG-I-like receptor signaling pathway	3/1216	62/7206	0.00939459994149
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1216	100/7206	0.0100500413292
ko05215	Prostate cancer	9/1216	111/7206	0.0103073879995
ko00380	Tryptophan metabolism	2/1216	50/7206	0.0121594640672
ko04915	Estrogen signaling pathway	33/1216	131/7206	0.0132740769747
ko04912	GnRH signaling pathway	31/1216	122/7206	0.0145061333648
ko03410	Base excision repair	1/1216	38/7206	0.0148283312754
ko04620	Toll-like receptor signaling pathway	8/1216	100/7206	0.0149215491096
ko04932	Non-alcoholic fatty liver disease (NAFLD)	19/1216	182/7206	0.0161456899209
ko05131	Shigellosis	6/1216	82/7206	0.0171037157473
ko04015	Rap1 signaling pathway	62/1216	278/7206	0.0175764852938
ko00310	Lysine degradation	5/1216	73/7206	0.01795314922
ko00260	Glycine, serine and threonine metabolism	2/1216	48/7206	0.0180846764596
ko04115	p53 signaling pathway	5/1216	74/7206	0.0181437357698
ko04668	TNF signaling pathway	11/1216	120/7206	0.0195315260401
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1216	14/7206	0.0201142364351
ko05222	Small cell lung cancer	7/1216	89/7206	0.0217249807214
ko01200	Carbon metabolism	12/1216	128/7206	0.0228980848321
ko05418	Fluid shear stress and atherosclerosis	18/1216	173/7206	0.0231637393884
ko05144	Malaria	2/1216	45/7206	0.0256404917798
ko00280	Valine, leucine and isoleucine degradation	3/1216	54/7206	0.0265776702979
ko04658	Th1 and Th2 cell differentiation	8/1216	96/7206	0.0269289585844
ko04916	Melanogenesis	34/1216	142/7206	0.03074054153
ko00562	Inositol phosphate metabolism	23/1216	89/7206	0.0314558289822
ko00983	Drug metabolism - other enzymes	2/1216	42/7206	0.0365005610726
ko05120	Epithelial cell signaling in Helicobacter pylori infection	23/1216	92/7206	0.0483238573876
ko05340	Primary immunodeficiency	1/1216	30/7206	0.0486263225148