ko pathway ratio_in_study ratio_in_pop p_value ko00120 Primary bile acid biosynthesis 12/620 20/7206 9.82403194349e-09 ko04060 Cytokine-cytokine receptor interaction 34/620 191/7206 3.55784370107e-05 ko04146 Peroxisome 20/620 89/7206 4.95882830758e-05 ko03320 PPAR signaling pathway 17/620 69/7206 5.2794769354e-05 ko03013 RNA transport 2/620 166/7206 6.53782583992e-05 ko04070 Phosphatidylinositol signaling system 23/620 112/7206 0.000101710872584 ko04710 Circadian rhythm 12/620 43/7206 0.000187711444106 ko03010 Ribosome 1/620 129/7206 0.000192943656962 ko04022 cGMP-PKG signaling pathway 35/620 216/7206 0.000281079712237 ko04610 Complement and coagulation cascades 17/620 79/7206 0.000313178604022 ko03040 Spliceosome 2/620 145/7206 0.000439066023098 ko05034 Alcoholism 7/620 238/7206 0.000576648048539 ko04020 Calcium signaling pathway 38/620 265/7206 0.00160770144472 ko04611 Platelet activation 26/620 163/7206 0.00171917445001 ko04270 Vascular smooth muscle contraction 25/620 154/7206 0.00191110738405 ko00140 Steroid hormone biosynthesis 10/620 41/7206 0.00199113356076 ko04110 Cell cycle 3/620 145/7206 0.00233064173696 ko05150 Staphylococcus aureus infection 9/620 36/7206 0.00276098366762 ko04730 Long-term depression 15/620 78/7206 0.00318223438591 ko05224 Breast cancer 5/620 174/7206 0.00367859307725 ko00592 alpha-Linolenic acid metabolism 6/620 19/7206 0.00405326271943 ko01040 Biosynthesis of unsaturated fatty acids 7/620 25/7206 0.00409926377105 ko00071 Fatty acid degradation 10/620 45/7206 0.00414351592682 ko03015 mRNA surveillance pathway 1/620 93/7206 0.00434081651721 ko04137 Mitophagy - animal 15/620 82/7206 0.0044397867263 ko04650 Natural killer cell mediated cytotoxicity 17/620 97/7206 0.00500762472342 ko04921 Oxytocin signaling pathway 30/620 209/7206 0.00538340659876 ko00100 Steroid biosynthesis 6/620 21/7206 0.00698975948739 ko04380 Osteoclast differentiation 21/620 134/7206 0.00721005940553 ko05321 Inflammatory bowel disease (IBD) 11/620 56/7206 0.00726914035104 ko00051 Fructose and mannose metabolism 9/620 42/7206 0.0082226861553 ko05203 Viral carcinogenesis 12/620 277/7206 0.00828393433406 ko04924 Renin secretion 15/620 86/7206 0.0099193552949 ko00561 Glycerolipid metabolism 12/620 63/7206 0.0100291321655 ko00362 Benzoate degradation 3/620 6/7206 0.0104013162449 ko00010 Glycolysis / Gluconeogenesis 13/620 74/7206 0.0109413261335 ko04630 Jak-STAT signaling pathway 20/620 132/7206 0.0113414259091 ko04672 Intestinal immune network for IgA production 8/620 37/7206 0.0117873736834 ko00982 Drug metabolism - cytochrome P450 8/620 37/7206 0.0117873736834 ko05340 Primary immunodeficiency 7/620 30/7206 0.0119160644957 ko04072 Phospholipase D signaling pathway 27/620 197/7206 0.0138691153344 ko00620 Pyruvate metabolism 9/620 46/7206 0.0149394906359 ko02010 ABC transporters 8/620 39/7206 0.0161389090252 ko04550 Signaling pathways regulating pluripotency of stem cells 6/620 165/7206 0.0165926239611 ko05322 Systemic lupus erythematosus 5/620 151/7206 0.0176599799119 ko00350 Tyrosine metabolism 7/620 33/7206 0.0199822861057 ko04925 Aldosterone synthesis and secretion 16/620 105/7206 0.0214273184812 ko04640 Hematopoietic cell lineage 11/620 64/7206 0.0225147270465 ko00680 Methane metabolism 7/620 34/7206 0.0233568586556 ko04970 Salivary secretion 15/620 95/7206 0.0243403974646 ko00983 Drug metabolism - other enzymes 8/620 42/7206 0.0246795950907 ko00830 Retinol metabolism 8/620 42/7206 0.0246795950907 ko04064 NF-kappa B signaling pathway 15/620 96/7206 0.0251175440344 ko00564 Glycerophospholipid metabolism 15/620 99/7206 0.0283239762366 ko04713 Circadian entrainment 19/620 136/7206 0.0302264239448 ko04080 Neuroactive ligand-receptor interaction 49/620 423/7206 0.0314038628912 ko04350 TGF-beta signaling pathway 3/620 103/7206 0.0330124611148 ko01522 Endocrine resistance 4/620 124/7206 0.0335570024963 ko04390 Hippo signaling pathway 8/620 188/7206 0.0336022690022 ko01212 Fatty acid metabolism 10/620 60/7206 0.0350638401733 ko04922 Glucagon signaling pathway 18/620 128/7206 0.0367293571284 ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis 2/620 4/7206 0.0394412200468 ko04136 Autophagy - other 6/620 31/7206 0.0456236496977 ko04930 Type II diabetes mellitus 9/620 54/7206 0.0468014230647 ko00950 Isoquinoline alkaloid biosynthesis 3/620 10/7206 0.0481234414442