ko pathway ratio_in_study ratio_in_pop p_value ko05340 Primary immunodeficiency 15/407 30/7206 1.04852897068e-11 ko04060 Cytokine-cytokine receptor interaction 36/407 191/7206 8.46609359077e-11 ko04380 Osteoclast differentiation 27/407 134/7206 4.69392851473e-09 ko05164 Influenza A 30/407 167/7206 1.0998395854e-08 ko04650 Natural killer cell mediated cytotoxicity 22/407 97/7206 1.34086555811e-08 ko04621 NOD-like receptor signaling pathway 28/407 157/7206 4.06354012643e-08 ko05140 Leishmaniasis 18/407 75/7206 1.13958590065e-07 ko04064 NF-kappa B signaling pathway 20/407 96/7206 2.75972097202e-07 ko05321 Inflammatory bowel disease (IBD) 15/407 56/7206 2.81976451527e-07 ko05168 Herpes simplex infection 29/407 182/7206 2.94281077847e-07 ko04659 Th17 cell differentiation 21/407 106/7206 3.40518612057e-07 ko05162 Measles 22/407 120/7206 7.31062491986e-07 ko04610 Complement and coagulation cascades 17/407 79/7206 1.35643220021e-06 ko05145 Toxoplasmosis 22/407 126/7206 1.73036954838e-06 ko04217 Necroptosis 27/407 178/7206 2.05489642907e-06 ko05320 Autoimmune thyroid disease 10/407 29/7206 2.24759749745e-06 ko05330 Allograft rejection 9/407 24/7206 3.27692946303e-06 ko04672 Intestinal immune network for IgA production 11/407 37/7206 3.66799714469e-06 ko04612 Antigen processing and presentation 16/407 77/7206 4.52210353657e-06 ko00120 Primary bile acid biosynthesis 8/407 20/7206 6.6768307921e-06 ko04660 T cell receptor signaling pathway 20/407 124/7206 1.76257182643e-05 ko05150 Staphylococcus aureus infection 10/407 36/7206 1.99529653926e-05 ko04658 Th1 and Th2 cell differentiation 17/407 96/7206 2.17356283104e-05 ko05332 Graft-versus-host disease 7/407 18/7206 3.21785755672e-05 ko04630 Jak-STAT signaling pathway 20/407 132/7206 4.48622040627e-05 ko05152 Tuberculosis 25/407 187/7206 6.22399197105e-05 ko04620 Toll-like receptor signaling pathway 16/407 100/7206 0.000134214442754 ko04640 Hematopoietic cell lineage 12/407 64/7206 0.000201654571008 ko04662 B cell receptor signaling pathway 14/407 88/7206 0.000371167914354 ko05144 Malaria 9/407 45/7206 0.000769983138799 ko04145 Phagosome 20/407 162/7206 0.000824068135447 ko05034 Alcoholism 3/407 238/7206 0.000882638148336 ko03013 RNA transport 1/407 166/7206 0.00104205611834 ko05161 Hepatitis B 21/407 173/7206 0.00113851725948 ko05323 Rheumatoid arthritis 13/407 89/7206 0.00135998527949 ko04940 Type I diabetes mellitus 7/407 32/7206 0.00171001066334 ko04623 Cytosolic DNA-sensing pathway 8/407 41/7206 0.00177773851398 ko05310 Asthma 5/407 17/7206 0.0019702785967 ko04622 RIG-I-like receptor signaling pathway 10/407 62/7206 0.00226085530375 ko05142 Chagas disease (American trypanosomiasis) 16/407 130/7206 0.00304342135686 ko04514 Cell adhesion molecules (CAMs) 16/407 130/7206 0.00304342135686 ko03040 Spliceosome 1/407 145/7206 0.00325083441819 ko05133 Pertussis 12/407 87/7206 0.00336313783047 ko05167 Kaposi's sarcoma-associated herpesvirus infection 21/407 191/7206 0.00351929951513 ko04668 TNF signaling pathway 15/407 120/7206 0.00384143076734 ko00982 Drug metabolism - cytochrome P450 7/407 37/7206 0.00409926802087 ko04723 Retrograde endocannabinoid signaling 2/407 175/7206 0.00427756727817 ko00980 Metabolism of xenobiotics by cytochrome P450 7/407 40/7206 0.00641698441812 ko05160 Hepatitis C 17/407 153/7206 0.00684072590846 ko00140 Steroid hormone biosynthesis 7/407 41/7206 0.00737212328083 ko00590 Arachidonic acid metabolism 8/407 52/7206 0.00814401110517 ko00051 Fructose and mannose metabolism 7/407 42/7206 0.00842853676149 ko00350 Tyrosine metabolism 6/407 33/7206 0.00943553351369 ko03050 Proteasome 8/407 54/7206 0.0102089948244 ko03010 Ribosome 1/407 129/7206 0.0104733471977 ko05418 Fluid shear stress and atherosclerosis 18/407 173/7206 0.011193916487 ko04062 Chemokine signaling pathway 20/407 201/7206 0.0122530654821 ko00360 Phenylalanine metabolism 4/407 17/7206 0.0132613281138 ko04310 Wnt signaling pathway 3/407 181/7206 0.0134291703469 ko04728 Dopaminergic synapse 3/407 185/7206 0.0139593507133 ko04611 Platelet activation 17/407 163/7206 0.0144600730247 ko04911 Insulin secretion 1/407 117/7206 0.0145044639388 ko00950 Isoquinoline alkaloid biosynthesis 3/407 10/7206 0.0159350150691 ko05204 Chemical carcinogenesis 7/407 48/7206 0.0172236262943 ko04110 Cell cycle 2/407 145/7206 0.0172622052732 ko04670 Leukocyte transendothelial migration 16/407 151/7206 0.0182867963283 ko05224 Breast cancer 3/407 174/7206 0.0186470774508 ko04210 Apoptosis 18/407 180/7206 0.0200494801601 ko04727 GABAergic synapse 1/407 110/7206 0.0209892299575 ko04012 ErbB signaling pathway 1/407 109/7206 0.0209944346953 ko04933 AGE-RAGE signaling pathway in diabetic complications 14/407 135/7206 0.0231334819116 ko04137 Mitophagy - animal 10/407 82/7206 0.0248114273078 ko04916 Melanogenesis 2/407 142/7206 0.0250774842475 ko04666 Fc gamma R-mediated phagocytosis 13/407 122/7206 0.0263760350413 ko05416 Viral myocarditis 7/407 55/7206 0.0339527004893 ko04390 Hippo signaling pathway 4/407 188/7206 0.0353078212735 ko01524 Platinum drug resistance 9/407 76/7206 0.0383571832094 ko04664 Fc epsilon RI signaling pathway 9/407 77/7206 0.0397646314573 ko04724 Glutamatergic synapse 3/407 152/7206 0.0485684528738