ko pathway ratio_in_study ratio_in_pop p_value ko04260 Cardiac muscle contraction 34/311 98/7206 1.40394819172e-22 ko00190 Oxidative phosphorylation 37/311 127/7206 1.7686140652e-21 ko05012 Parkinson's disease 38/311 155/7206 3.80442610817e-19 ko05010 Alzheimer's disease 42/311 202/7206 3.37951431987e-18 ko05410 Hypertrophic cardiomyopathy (HCM) 30/311 100/7206 5.49964879696e-18 ko05016 Huntington's disease 40/311 215/7206 1.34794633698e-15 ko05414 Dilated cardiomyopathy 28/311 112/7206 1.35087877916e-14 ko01200 Carbon metabolism 27/311 128/7206 3.35162994657e-12 ko00020 Citrate cycle (TCA cycle) 14/311 35/7206 5.95205310675e-11 ko04261 Adrenergic signaling in cardiomyocytes 31/311 205/7206 6.59622287925e-10 ko00010 Glycolysis / Gluconeogenesis 18/311 74/7206 1.33620036711e-09 ko04974 Protein digestion and absorption 20/311 96/7206 2.99778205668e-09 ko04932 Non-alcoholic fatty liver disease (NAFLD) 28/311 182/7206 3.12816563268e-09 ko04510 Focal adhesion 31/311 240/7206 3.19382809154e-08 ko04512 ECM-receptor interaction 16/311 79/7206 1.79854305675e-07 ko05416 Viral myocarditis 13/311 55/7206 3.95980886153e-07 ko00620 Pyruvate metabolism 11/311 46/7206 2.79195629804e-06 ko04723 Retrograde endocannabinoid signaling 22/311 175/7206 5.45972751355e-06 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 14/311 79/7206 5.6927062084e-06 ko00710 Carbon fixation in photosynthetic organisms 8/311 27/7206 1.19010087845e-05 ko01230 Biosynthesis of amino acids 12/311 85/7206 0.000261136994136 ko04020 Calcium signaling pathway 25/311 265/7206 0.000267432584628 ko04022 cGMP-PKG signaling pathway 21/311 216/7206 0.000454022816122 ko04921 Oxytocin signaling pathway 20/311 209/7206 0.000744291743295 ko04964 Proximal tubule bicarbonate reclamation 6/311 29/7206 0.00126017987775 ko00030 Pentose phosphate pathway 6/311 32/7206 0.00215585921698 ko00680 Methane metabolism 6/311 34/7206 0.00297585491825 ko04072 Phospholipase D signaling pathway 1/311 197/7206 0.0035566509825 ko04210 Apoptosis 1/311 180/7206 0.00490008248111 ko04728 Dopaminergic synapse 1/311 185/7206 0.00499969603625 ko05152 Tuberculosis 1/311 187/7206 0.00511491289444 ko00250 Alanine, aspartate and glutamate metabolism 6/311 38/7206 0.00528619135786 ko00280 Valine, leucine and isoleucine degradation 7/311 54/7206 0.0080714891901 ko04014 Ras signaling pathway 4/311 279/7206 0.0102053520403 ko04015 Rap1 signaling pathway 4/311 278/7206 0.0102102909113 ko04071 Sphingolipid signaling pathway 1/311 162/7206 0.0103180556006 ko03013 RNA transport 1/311 166/7206 0.0104826767033 ko04371 Apelin signaling pathway 15/311 177/7206 0.0127242690311 ko00350 Tyrosine metabolism 5/311 33/7206 0.0127319830344 ko00640 Propanoate metabolism 5/311 34/7206 0.0144140740889 ko05203 Viral carcinogenesis 4/311 277/7206 0.0144901321786 ko05160 Hepatitis C 1/311 153/7206 0.0149334585625 ko04724 Glutamatergic synapse 1/311 152/7206 0.0149397406238 ko00500 Starch and sucrose metabolism 5/311 35/7206 0.0162391069209 ko04060 Cytokine-cytokine receptor interaction 2/311 191/7206 0.0177375741004 ko05167 Kaposi's sarcoma-associated herpesvirus infection 2/311 191/7206 0.0177375741004 ko04150 mTOR signaling pathway 2/311 184/7206 0.0252703078351 ko04922 Glucagon signaling pathway 11/311 128/7206 0.0254200684392 ko05231 Choline metabolism in cancer 1/311 134/7206 0.0310752562255 ko04120 Ubiquitin mediated proteolysis 1/311 138/7206 0.0315293895126 ko04114 Oocyte meiosis 1/311 139/7206 0.0317826718865 ko00051 Fructose and mannose metabolism 5/311 42/7206 0.0333634607216 ko04024 cAMP signaling pathway 5/311 279/7206 0.0338419037183 ko05144 Malaria 5/311 45/7206 0.0432027729113 ko05142 Chagas disease (American trypanosomiasis) 1/311 130/7206 0.0458074567776 ko04630 Jak-STAT signaling pathway 1/311 132/7206 0.0467873190671 ko00330 Arginine and proline metabolism 6/311 61/7206 0.0467949304852 ko04550 Signaling pathways regulating pluripotency of stem cells 2/311 165/7206 0.0494774857949