ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 56/455 191/7206 1.07029478172e-23 ko04380 Osteoclast differentiation 37/455 134/7206 5.04718838526e-15 ko05164 Influenza A 39/455 167/7206 3.56536219061e-13 ko04650 Natural killer cell mediated cytotoxicity 28/455 97/7206 3.57402072919e-12 ko05140 Leishmaniasis 24/455 75/7206 1.12785314978e-11 ko05152 Tuberculosis 39/455 187/7206 1.57616873061e-11 ko04621 NOD-like receptor signaling pathway 35/455 157/7206 2.52644529347e-11 ko05162 Measles 30/455 120/7206 3.36820634117e-11 ko05340 Primary immunodeficiency 15/455 30/7206 5.19914771853e-11 ko05321 Inflammatory bowel disease (IBD) 20/455 56/7206 6.32251412922e-11 ko04064 NF-kappa B signaling pathway 26/455 96/7206 1.04699451959e-10 ko05150 Staphylococcus aureus infection 16/455 36/7206 1.11336165551e-10 ko05330 Allograft rejection 13/455 24/7206 2.82198072334e-10 ko04660 T cell receptor signaling pathway 29/455 124/7206 4.07732480831e-10 ko05145 Toxoplasmosis 29/455 126/7206 6.12391727441e-10 ko04659 Th17 cell differentiation 26/455 106/7206 1.11819320899e-09 ko04620 Toll-like receptor signaling pathway 25/455 100/7206 1.53193365218e-09 ko05168 Herpes simplex infection 35/455 182/7206 1.8531870563e-09 ko04630 Jak-STAT signaling pathway 29/455 132/7206 1.96350026835e-09 ko05320 Autoimmune thyroid disease 13/455 29/7206 5.72373696325e-09 ko04610 Complement and coagulation cascades 21/455 79/7206 9.82594984502e-09 ko04217 Necroptosis 33/455 178/7206 1.42566006483e-08 ko05144 Malaria 15/455 45/7206 4.77749241994e-08 ko04658 Th1 and Th2 cell differentiation 22/455 96/7206 8.21284091269e-08 ko05167 Kaposi's sarcoma-associated herpesvirus infection 33/455 191/7206 8.48331932478e-08 ko05323 Rheumatoid arthritis 21/455 89/7206 9.49587813143e-08 ko04612 Antigen processing and presentation 19/455 77/7206 1.83254379024e-07 ko04672 Intestinal immune network for IgA production 13/455 37/7206 1.88150232691e-07 ko04640 Hematopoietic cell lineage 17/455 64/7206 2.59660844577e-07 ko05332 Graft-versus-host disease 9/455 18/7206 4.29928253895e-07 ko05133 Pertussis 19/455 87/7206 1.39562332583e-06 ko05310 Asthma 8/455 17/7206 3.48146789606e-06 ko04062 Chemokine signaling pathway 30/455 201/7206 9.43779877891e-06 ko05161 Hepatitis B 27/455 173/7206 9.64138777354e-06 ko05142 Chagas disease (American trypanosomiasis) 22/455 130/7206 1.78173296672e-05 ko04662 B cell receptor signaling pathway 17/455 88/7206 2.80719845454e-05 ko04668 TNF signaling pathway 20/455 120/7206 5.35970506021e-05 ko04145 Phagosome 24/455 162/7206 9.43876298621e-05 ko04622 RIG-I-like receptor signaling pathway 13/455 62/7206 0.000102282324353 ko04940 Type I diabetes mellitus 9/455 32/7206 0.000111799674714 ko04623 Cytosolic DNA-sensing pathway 10/455 41/7206 0.00017309798344 ko04723 Retrograde endocannabinoid signaling 1/455 175/7206 0.000218468142058 ko05132 Salmonella infection 16/455 98/7206 0.00037720506904 ko04933 AGE-RAGE signaling pathway in diabetic complications 19/455 135/7206 0.000906716494269 ko05034 Alcoholism 4/455 238/7206 0.000998751363261 ko04728 Dopaminergic synapse 2/455 185/7206 0.00102687738996 ko05224 Breast cancer 2/455 174/7206 0.00142386794317 ko04916 Melanogenesis 1/455 142/7206 0.00148882203357 ko03040 Spliceosome 1/455 145/7206 0.00150971554641 ko04611 Platelet activation 21/455 163/7206 0.00159777749805 ko04670 Leukocyte transendothelial migration 20/455 151/7206 0.00176754961955 ko04657 IL-17 signaling pathway 13/455 87/7206 0.00297271223657 ko04664 Fc epsilon RI signaling pathway 12/455 77/7206 0.00297744669051 ko05143 African trypanosomiasis 7/455 32/7206 0.00322885418875 ko04390 Hippo signaling pathway 3/455 188/7206 0.00346183425534 ko05160 Hepatitis C 19/455 153/7206 0.00388008584092 ko04666 Fc gamma R-mediated phagocytosis 16/455 122/7206 0.0043774739774 ko04310 Wnt signaling pathway 3/455 181/7206 0.00484877041713 ko05146 Amoebiasis 14/455 99/7206 0.00501451311225 ko05131 Shigellosis 12/455 82/7206 0.00504489906228 ko04137 Mitophagy - animal 12/455 82/7206 0.00504489906228 ko04514 Cell adhesion molecules (CAMs) 17/455 130/7206 0.00509835997516 ko05202 Transcriptional misregulation in cancer 22/455 188/7206 0.00539688989106 ko04724 Glutamatergic synapse 2/455 152/7206 0.00608160011195 ko03050 Proteasome 9/455 54/7206 0.00614970122514 ko00120 Primary bile acid biosynthesis 5/455 20/7206 0.00689435742423 ko04210 Apoptosis 21/455 180/7206 0.00728612624801 ko05166 HTLV-I infection 30/455 292/7206 0.00920984944923 ko04972 Pancreatic secretion 1/455 111/7206 0.0098179265129 ko05020 Prion diseases 7/455 40/7206 0.0115687674022 ko04713 Circadian entrainment 2/455 136/7206 0.0120109475847 ko04080 Neuroactive ligand-receptor interaction 15/455 423/7206 0.0131462660312 ko04925 Aldosterone synthesis and secretion 1/455 105/7206 0.0142588455363 ko00051 Fructose and mannose metabolism 7/455 42/7206 0.0150229527161 ko00590 Arachidonic acid metabolism 8/455 52/7206 0.0153486467916 ko04144 Endocytosis 33/455 342/7206 0.0159774856754 ko05418 Fluid shear stress and atherosclerosis 19/455 173/7206 0.0165315765573 ko04020 Calcium signaling pathway 8/455 265/7206 0.0202336381045 ko04971 Gastric acid secretion 1/455 98/7206 0.0206446670472 ko05416 Viral myocarditis 8/455 55/7206 0.021074659974 ko05134 Legionellosis 10/455 74/7206 0.0250168191226 ko01200 Carbon metabolism 2/455 128/7206 0.0250939407083 ko04910 Insulin signaling pathway 4/455 172/7206 0.0252907630249 ko05169 Epstein-Barr virus infection 21/455 206/7206 0.0279651172054 ko04911 Insulin secretion 2/455 117/7206 0.0337188624075 ko04550 Signaling pathways regulating pluripotency of stem cells 4/455 165/7206 0.0342498362466 ko04110 Cell cycle 3/455 145/7206 0.0358351030832 ko04066 HIF-1 signaling pathway 14/455 123/7206 0.036196897369 ko04360 Axon guidance 7/455 233/7206 0.0383255817545 ko01230 Biosynthesis of amino acids 1/455 85/7206 0.043066250143 ko04727 GABAergic synapse 2/455 110/7206 0.0471816678893 ko04726 Serotonergic synapse 3/455 137/7206 0.0484097297367 ko04114 Oocyte meiosis 3/455 139/7206 0.0494770085687