ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	152/1045	423/7206	6.37805801106e-30
ko04724	Glutamatergic synapse	80/1045	152/7206	5.29703118144e-29
ko04728	Dopaminergic synapse	82/1045	185/7206	3.23683269052e-23
ko05033	Nicotine addiction	41/1045	56/7206	3.75770563636e-23
ko05032	Morphine addiction	57/1045	110/7206	1.64502643685e-20
ko04721	Synaptic vesicle cycle	47/1045	80/7206	3.92464268594e-20
ko04727	GABAergic synapse	56/1045	110/7206	1.07940294006e-19
ko04725	Cholinergic synapse	70/1045	160/7206	1.44166581038e-19
ko04713	Circadian entrainment	63/1045	136/7206	2.8076536403e-19
ko04723	Retrograde endocannabinoid signaling	68/1045	175/7206	8.77052651919e-16
ko04024	cAMP signaling pathway	92/1045	279/7206	2.29505690527e-15
ko04911	Insulin secretion	49/1045	117/7206	3.66862384488e-13
ko04742	Taste transduction	31/1045	61/7206	1.9346580769e-11
ko04261	Adrenergic signaling in cardiomyocytes	66/1045	205/7206	6.3230896792e-11
ko04360	Axon guidance	72/1045	233/7206	7.524375987e-11
ko04726	Serotonergic synapse	49/1045	137/7206	3.25632571962e-10
ko04921	Oxytocin signaling pathway	65/1045	209/7206	7.19866410145e-10
ko04744	Phototransduction	21/1045	36/7206	1.28617804272e-09
ko03040	Spliceosome	1/1045	145/7206	5.78519314243e-09
ko05031	Amphetamine addiction	35/1045	91/7206	1.31855915252e-08
ko04720	Long-term potentiation	36/1045	99/7206	4.55451597425e-08
ko04020	Calcium signaling pathway	71/1045	265/7206	1.00544762262e-07
ko05030	Cocaine addiction	28/1045	73/7206	4.01396513546e-07
ko05203	Viral carcinogenesis	14/1045	277/7206	5.13900704371e-07
ko05168	Herpes simplex infection	6/1045	182/7206	9.66697665574e-07
ko03013	RNA transport	5/1045	166/7206	1.07309007415e-06
ko04010	MAPK signaling pathway	78/1045	321/7206	2.01365530903e-06
ko04970	Salivary secretion	32/1045	95/7206	2.13310958562e-06
ko04060	Cytokine-cytokine receptor interaction	8/1045	191/7206	5.37425566866e-06
ko04120	Ubiquitin mediated proteolysis	4/1045	138/7206	7.89125227151e-06
ko04925	Aldosterone synthesis and secretion	33/1045	105/7206	8.24256072703e-06
ko05322	Systemic lupus erythematosus	5/1045	151/7206	1.03256324312e-05
ko04514	Cell adhesion molecules (CAMs)	38/1045	130/7206	1.24251525969e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1045	79/7206	1.24305943318e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	25/1045	74/7206	3.15582990823e-05
ko04141	Protein processing in endoplasmic reticulum	9/1045	184/7206	4.43257499773e-05
ko05164	Influenza A	8/1045	167/7206	8.16796605848e-05
ko04971	Gastric acid secretion	29/1045	98/7206	0.000116624055726
ko03008	Ribosome biogenesis in eukaryotes	1/1045	79/7206	0.000136006340836
ko04740	Olfactory transduction	25/1045	80/7206	0.000148588425065
ko04621	NOD-like receptor signaling pathway	8/1045	157/7206	0.000219996222741
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1045	14/7206	0.000253261031748
ko04022	cGMP-PKG signaling pathway	51/1045	216/7206	0.000263698210972
ko00240	Pyrimidine metabolism	4/1045	110/7206	0.000318293070861
ko05414	Dilated cardiomyopathy	31/1045	112/7206	0.000337341445403
ko04961	Endocrine and other factor-regulated calcium reabsorption	19/1045	59/7206	0.000527087406424
ko04966	Collecting duct acid secretion	11/1045	26/7206	0.000538170974631
ko04972	Pancreatic secretion	30/1045	111/7206	0.00054731623056
ko04915	Estrogen signaling pathway	34/1045	131/7206	0.000597251159593
ko04070	Phosphatidylinositol signaling system	30/1045	112/7206	0.0005984560124
ko04260	Cardiac muscle contraction	27/1045	98/7206	0.00071546090621
ko05205	Proteoglycans in cancer	21/1045	271/7206	0.000780281323121
ko04976	Bile secretion	23/1045	80/7206	0.00107166731332
ko04072	Phospholipase D signaling pathway	45/1045	197/7206	0.00138741422882
ko05140	Leishmaniasis	2/1045	75/7206	0.00138859947897
ko03018	RNA degradation	3/1045	84/7206	0.00167152056382
ko04730	Long-term depression	22/1045	78/7206	0.00168980449448
ko05169	Epstein-Barr virus infection	15/1045	206/7206	0.00175834205999
ko04064	NF-kappa B signaling pathway	4/1045	96/7206	0.00189181036431
ko01200	Carbon metabolism	7/1045	128/7206	0.00210597080331
ko04924	Renin secretion	23/1045	86/7206	0.00290330171783
ko04540	Gap junction	31/1045	128/7206	0.00325303759488
ko00480	Glutathione metabolism	1/1045	55/7206	0.00325514899051
ko05321	Inflammatory bowel disease (IBD)	1/1045	56/7206	0.00336814062504
ko04146	Peroxisome	4/1045	89/7206	0.00375326005232
ko00590	Arachidonic acid metabolism	1/1045	52/7206	0.00484587067904
ko04964	Proximal tubule bicarbonate reclamation	10/1045	29/7206	0.00572799835126
ko05410	Hypertrophic cardiomyopathy (HCM)	25/1045	100/7206	0.00587875055151
ko00561	Glycerolipid metabolism	2/1045	63/7206	0.00622399633251
ko04640	Hematopoietic cell lineage	2/1045	64/7206	0.00639482944301
ko04745	Phototransduction - fly	12/1045	38/7206	0.00831818598573
ko00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	9/1045	26/7206	0.00839618568966
ko04014	Ras signaling pathway	56/1045	279/7206	0.00914528496325
ko00330	Arginine and proline metabolism	2/1045	61/7206	0.00923367033794
ko04391	Hippo signaling pathway - fly	22/1045	90/7206	0.0102377923892
ko05110	Vibrio cholerae infection	17/1045	63/7206	0.010277963829
ko04214	Apoptosis - fly	3/1045	72/7206	0.0103466884444
ko03420	Nucleotide excision repair	1/1045	46/7206	0.0107202614062
ko04916	Melanogenesis	32/1045	142/7206	0.0108173039921
ko05162	Measles	8/1045	120/7206	0.0123015936212
ko04371	Apelin signaling pathway	38/1045	177/7206	0.0123694233749
ko04932	Non-alcoholic fatty liver disease (NAFLD)	15/1045	182/7206	0.0137762193531
ko04612	Antigen processing and presentation	4/1045	77/7206	0.0144536409073
ko03320	PPAR signaling pathway	3/1045	69/7206	0.0146035865154
ko05145	Toxoplasmosis	9/1045	126/7206	0.0149464289295
ko03022	Basal transcription factors	1/1045	44/7206	0.016146598401
ko04110	Cell cycle	11/1045	145/7206	0.0164666829162
ko00071	Fatty acid degradation	1/1045	45/7206	0.0167876297348
ko00280	Valine, leucine and isoleucine degradation	2/1045	54/7206	0.0187889056906
ko04062	Chemokine signaling pathway	41/1045	201/7206	0.0193254270728
ko05133	Pertussis	5/1045	87/7206	0.0201238596987
ko04962	Vasopressin-regulated water reabsorption	15/1045	58/7206	0.022452805294
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1045	40/7206	0.0236125506578
ko05161	Hepatitis B	15/1045	173/7206	0.0281678516181
ko04622	RIG-I-like receptor signaling pathway	3/1045	62/7206	0.028198701426
ko00600	Sphingolipid metabolism	3/1045	63/7206	0.0288143093211
ko04918	Thyroid hormone synthesis	20/1045	86/7206	0.0294632231711
ko04930	Type II diabetes mellitus	14/1045	54/7206	0.0298252651791
ko00564	Glycerophospholipid metabolism	7/1045	99/7206	0.0309934009807
ko04217	Necroptosis	16/1045	178/7206	0.0312753713412
ko04923	Regulation of lipolysis in adipocytes	18/1045	77/7206	0.0334738195117
ko00982	Drug metabolism - cytochrome P450	1/1045	37/7206	0.0349556901607
ko04750	Inflammatory mediator regulation of TRP channels	26/1045	122/7206	0.0374553237197
ko00380	Tryptophan metabolism	2/1045	50/7206	0.0404344093497
ko04973	Carbohydrate digestion and absorption	11/1045	42/7206	0.0443605597331
ko04630	Jak-STAT signaling pathway	11/1045	132/7206	0.0450199709276
ko00562	Inositol phosphate metabolism	20/1045	89/7206	0.0469006329165