ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 48/358 152/7206 1.23815378578e-26 ko04080 Neuroactive ligand-receptor interaction 78/358 423/7206 9.73083832356e-26 ko05033 Nicotine addiction 25/358 56/7206 1.51985472084e-18 ko04744 Phototransduction 18/358 36/7206 8.94091201226e-15 ko04727 GABAergic synapse 28/358 110/7206 2.90521475841e-13 ko04713 Circadian entrainment 30/358 136/7206 2.27880426699e-12 ko04723 Retrograde endocannabinoid signaling 34/358 175/7206 3.44740615889e-12 ko04911 Insulin secretion 26/358 117/7206 5.93469778369e-11 ko04728 Dopaminergic synapse 33/358 185/7206 8.21720714787e-11 ko05032 Morphine addiction 24/358 110/7206 4.97910652795e-10 ko04024 cAMP signaling pathway 40/358 279/7206 7.86771445664e-10 ko05030 Cocaine addiction 19/358 73/7206 1.42366204274e-09 ko04720 Long-term potentiation 22/358 99/7206 1.85695431072e-09 ko04721 Synaptic vesicle cycle 19/358 80/7206 7.52098531556e-09 ko04921 Oxytocin signaling pathway 32/358 209/7206 8.60897985608e-09 ko05031 Amphetamine addiction 20/358 91/7206 1.26397230706e-08 ko04261 Adrenergic signaling in cardiomyocytes 29/358 205/7206 2.58480685594e-07 ko04725 Cholinergic synapse 25/358 160/7206 2.62709492684e-07 ko04726 Serotonergic synapse 22/358 137/7206 8.66102337355e-07 ko05014 Amyotrophic lateral sclerosis (ALS) 14/358 74/7206 1.29716328958e-05 ko04970 Salivary secretion 16/358 95/7206 1.4877044553e-05 ko04020 Calcium signaling pathway 30/358 265/7206 1.86223995093e-05 ko04260 Cardiac muscle contraction 16/358 98/7206 2.22881460333e-05 ko04730 Long-term depression 14/358 78/7206 2.42927960359e-05 ko04742 Taste transduction 12/358 61/7206 3.59921753527e-05 ko04925 Aldosterone synthesis and secretion 16/358 105/7206 5.35417389058e-05 ko04010 MAPK signaling pathway 33/358 321/7206 5.81270345557e-05 ko05203 Viral carcinogenesis 2/358 277/7206 0.000174724059328 ko04022 cGMP-PKG signaling pathway 24/358 216/7206 0.000179601864922 ko04971 Gastric acid secretion 14/358 98/7206 0.000313389409799 ko04072 Phospholipase D signaling pathway 22/358 197/7206 0.000325444625921 ko04972 Pancreatic secretion 15/358 111/7206 0.000358437828423 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 12/358 79/7206 0.000471832910385 ko04514 Cell adhesion molecules (CAMs) 15/358 130/7206 0.00189008054129 ko04745 Phototransduction - fly 7/358 38/7206 0.00233799046385 ko04964 Proximal tubule bicarbonate reclamation 6/358 29/7206 0.00258780804299 ko05010 Alzheimer's disease 20/358 202/7206 0.00274711429724 ko05169 Epstein-Barr virus infection 2/358 206/7206 0.0030376366629 ko05414 Dilated cardiomyopathy 13/358 112/7206 0.00353175867468 ko05205 Proteoglycans in cancer 4/358 271/7206 0.00391023590413 ko04810 Regulation of actin cytoskeleton 4/358 264/7206 0.00546356918271 ko05166 HTLV-I infection 5/358 292/7206 0.00551411446188 ko05322 Systemic lupus erythematosus 1/358 151/7206 0.00705983433611 ko04961 Endocrine and other factor-regulated calcium reabsorption 8/358 59/7206 0.00826457800242 ko04210 Apoptosis 2/358 180/7206 0.0087545671632 ko04932 Non-alcoholic fatty liver disease (NAFLD) 2/358 182/7206 0.00877032347448 ko05034 Alcoholism 21/358 238/7206 0.00926385357687 ko04924 Renin secretion 10/358 86/7206 0.00985470220179 ko05224 Breast cancer 2/358 174/7206 0.0124267235984 ko04120 Ubiquitin mediated proteolysis 1/358 138/7206 0.0152868328748 ko05410 Hypertrophic cardiomyopathy (HCM) 11/358 100/7206 0.0163443076343 ko04550 Signaling pathways regulating pluripotency of stem cells 2/358 165/7206 0.0175074797997 ko04750 Inflammatory mediator regulation of TRP channels 12/358 122/7206 0.0196099164694 ko04621 NOD-like receptor signaling pathway 2/358 157/7206 0.0246552753613 ko04060 Cytokine-cytokine receptor interaction 3/358 191/7206 0.0262932408756 ko04510 Focal adhesion 5/358 240/7206 0.0334258136086 ko05160 Hepatitis C 2/358 153/7206 0.0355384354119 ko04218 Cellular senescence 3/358 177/7206 0.035542308281 ko05110 Vibrio cholerae infection 7/358 63/7206 0.0356815877688 ko04540 Gap junction 12/358 128/7206 0.0357062938104 ko04141 Protein processing in endoplasmic reticulum 3/358 184/7206 0.0365426085611 ko04966 Collecting duct acid secretion 4/358 26/7206 0.0376820639435 ko04918 Thyroid hormone synthesis 9/358 86/7206 0.038432732514 ko00240 Pyrimidine metabolism 1/358 110/7206 0.0443661925105 ko05215 Prostate cancer 1/358 111/7206 0.0445994597333 ko04978 Mineral absorption 5/358 40/7206 0.0464626434649 ko04910 Insulin signaling pathway 3/358 172/7206 0.0488706111649 ko05161 Hepatitis B 3/358 173/7206 0.0490904900219 ko02025 Biofilm formation - Pseudomonas aeruginosa 1/358 1/7206 0.0496808215375