ko pathway ratio_in_study ratio_in_pop p_value ko04070 Phosphatidylinositol signaling system 28/664 112/7206 6.39515892113e-07 ko04650 Natural killer cell mediated cytotoxicity 25/664 97/7206 1.39053038822e-06 ko04020 Calcium signaling pathway 48/664 265/7206 3.76860203091e-06 ko03040 Spliceosome 1/664 145/7206 1.72571279359e-05 ko04925 Aldosterone synthesis and secretion 24/664 105/7206 2.09052424615e-05 ko04922 Glucagon signaling pathway 27/664 128/7206 3.427799511e-05 ko04022 cGMP-PKG signaling pathway 39/664 216/7206 3.57626675021e-05 ko04921 Oxytocin signaling pathway 38/664 209/7206 4.39227787768e-05 ko04710 Circadian rhythm 13/664 43/7206 8.27718382759e-05 ko03010 Ribosome 1/664 129/7206 8.4273651914e-05 ko04713 Circadian entrainment 27/664 136/7206 0.000118553175886 ko04137 Mitophagy - animal 19/664 82/7206 0.000123269504873 ko05031 Amphetamine addiction 20/664 91/7206 0.000178945632122 ko04110 Cell cycle 2/664 145/7206 0.000205014176553 ko04720 Long-term potentiation 21/664 99/7206 0.000275958390844 ko04060 Cytokine-cytokine receptor interaction 33/664 191/7206 0.000329586226567 ko04745 Phototransduction - fly 11/664 38/7206 0.000442829869699 ko04725 Cholinergic synapse 28/664 160/7206 0.000773009363193 ko03013 RNA transport 4/664 166/7206 0.000922841016464 ko04970 Salivary secretion 19/664 95/7206 0.000995074342499 ko04136 Autophagy - other 9/664 31/7206 0.00142725999692 ko00120 Primary bile acid biosynthesis 7/664 20/7206 0.00145302965543 ko04924 Renin secretion 17/664 86/7206 0.00211399108717 ko04371 Apelin signaling pathway 29/664 177/7206 0.00216060720666 ko04610 Complement and coagulation cascades 16/664 79/7206 0.00240905118202 ko04270 Vascular smooth muscle contraction 26/664 154/7206 0.00265175080536 ko00051 Fructose and mannose metabolism 10/664 42/7206 0.00399389086726 ko04726 Serotonergic synapse 23/664 137/7206 0.00414045803087 ko04014 Ras signaling pathway 40/664 279/7206 0.00418740222088 ko04626 Plant-pathogen interaction 6/664 18/7206 0.00422401751304 ko05152 Tuberculosis 29/664 187/7206 0.00456262817556 ko05340 Primary immunodeficiency 8/664 30/7206 0.004666213149 ko03320 PPAR signaling pathway 14/664 69/7206 0.00481347310758 ko05224 Breast cancer 6/664 174/7206 0.00494460665454 ko04611 Platelet activation 26/664 163/7206 0.005538125597 ko00592 alpha-Linolenic acid metabolism 6/664 19/7206 0.00570050354887 ko04380 Osteoclast differentiation 22/664 134/7206 0.0063235450899 ko04066 HIF-1 signaling pathway 21/664 123/7206 0.00654414660088 ko05322 Systemic lupus erythematosus 5/664 151/7206 0.00954966755023 ko05230 Central carbon metabolism in cancer 15/664 81/7206 0.00998859480143 ko00680 Methane metabolism 8/664 34/7206 0.0104256014576 ko04971 Gastric acid secretion 17/664 98/7206 0.0120392933335 ko00564 Glycerophospholipid metabolism 17/664 99/7206 0.0125203589779 ko04911 Insulin secretion 19/664 117/7206 0.0142473129323 ko04640 Hematopoietic cell lineage 12/664 64/7206 0.0147676531869 ko04724 Glutamatergic synapse 23/664 152/7206 0.0154266551165 ko04730 Long-term depression 14/664 78/7206 0.0155716655809 ko05321 Inflammatory bowel disease (IBD) 11/664 56/7206 0.0162902406817 ko04072 Phospholipase D signaling pathway 28/664 197/7206 0.0175859294275 ko04138 Autophagy - yeast 14/664 81/7206 0.0186857178921 ko05167 Kaposi's sarcoma-associated herpesvirus infection 27/664 191/7206 0.0220467980423 ko00010 Glycolysis / Gluconeogenesis 13/664 74/7206 0.0230642750041 ko04350 TGF-beta signaling pathway 3/664 103/7206 0.0238880504685 ko05323 Rheumatoid arthritis 15/664 89/7206 0.0241549851093 ko00562 Inositol phosphate metabolism 15/664 89/7206 0.0241549851093 ko04750 Inflammatory mediator regulation of TRP channels 19/664 122/7206 0.0251306890426 ko04711 Circadian rhythm - fly 4/664 13/7206 0.0260092384748 ko04660 T cell receptor signaling pathway 19/664 124/7206 0.0266233082776 ko04141 Protein processing in endoplasmic reticulum 9/664 184/7206 0.0383232983449 ko04662 B cell receptor signaling pathway 14/664 88/7206 0.0391416081957 ko04146 Peroxisome 14/664 89/7206 0.041085150517 ko04659 Th17 cell differentiation 16/664 106/7206 0.0417929431263 ko05150 Staphylococcus aureus infection 7/664 36/7206 0.0431118449821 ko00561 Glycerolipid metabolism 11/664 63/7206 0.0438991879103 ko03015 mRNA surveillance pathway 3/664 93/7206 0.0451903656169 ko04080 Neuroactive ligand-receptor interaction 51/664 423/7206 0.0456850973095 ko05214 Glioma 13/664 79/7206 0.0466146954094 ko04658 Th1 and Th2 cell differentiation 15/664 96/7206 0.0474398766762 ko00140 Steroid hormone biosynthesis 8/664 41/7206 0.0498282558352