ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 23/127 423/7206 1.00916505632e-06 ko04725 Cholinergic synapse 12/127 160/7206 2.25109300378e-05 ko04972 Pancreatic secretion 10/127 111/7206 2.31847928667e-05 ko05014 Amyotrophic lateral sclerosis (ALS) 8/127 74/7206 4.24330340178e-05 ko04921 Oxytocin signaling pathway 13/127 209/7206 7.2989392478e-05 ko04540 Gap junction 10/127 128/7206 7.92585243135e-05 ko04925 Aldosterone synthesis and secretion 9/127 105/7206 8.92100775129e-05 ko04024 cAMP signaling pathway 15/127 279/7206 0.00010600435994 ko04970 Salivary secretion 8/127 95/7206 0.000251276779605 ko04974 Protein digestion and absorption 8/127 96/7206 0.000270122326085 ko04971 Gastric acid secretion 8/127 98/7206 0.000311291421542 ko04720 Long-term potentiation 8/127 99/7206 0.000333720418623 ko05231 Choline metabolism in cancer 9/127 134/7206 0.000564072699069 ko04978 Mineral absorption 5/127 40/7206 0.000630627994173 ko04742 Taste transduction 6/127 61/7206 0.00066884120204 ko04924 Renin secretion 7/127 86/7206 0.000758055011273 ko04261 Adrenergic signaling in cardiomyocytes 11/127 205/7206 0.00093667102801 ko04911 Insulin secretion 8/127 117/7206 0.0010208053401 ko05031 Amphetamine addiction 7/127 91/7206 0.00106193583383 ko04270 Vascular smooth muscle contraction 9/127 154/7206 0.00152310362309 ko04964 Proximal tubule bicarbonate reclamation 4/127 29/7206 0.00155334843255 ko04976 Bile secretion 6/127 80/7206 0.00275818496806 ko04726 Serotonergic synapse 8/127 137/7206 0.00279211557955 ko04961 Endocrine and other factor-regulated calcium reabsorption 5/127 59/7206 0.00367631121198 ko04724 Glutamatergic synapse 8/127 152/7206 0.00525924897436 ko04750 Inflammatory mediator regulation of TRP channels 7/127 122/7206 0.00561154255147 ko04960 Aldosterone-regulated sodium reabsorption 4/127 41/7206 0.00562933735087 ko04020 Calcium signaling pathway 11/127 265/7206 0.00689154967748 ko04650 Natural killer cell mediated cytotoxicity 6/127 97/7206 0.00712027682176 ko04260 Cardiac muscle contraction 6/127 98/7206 0.00747769689602 ko04015 Rap1 signaling pathway 11/127 278/7206 0.00972309563047 ko04370 VEGF signaling pathway 5/127 77/7206 0.0112934206292 ko04371 Apelin signaling pathway 8/127 177/7206 0.0126968116313 ko04022 cGMP-PKG signaling pathway 9/127 216/7206 0.0137985820721 ko04728 Dopaminergic synapse 8/127 185/7206 0.0162163412388 ko04670 Leukocyte transendothelial migration 7/127 151/7206 0.0170278767997 ko04918 Thyroid hormone synthesis 5/127 86/7206 0.0175748507699 ko02025 Biofilm formation - Pseudomonas aeruginosa 1/127 1/7206 0.0176242020538 ko04530 Tight junction 9/127 228/7206 0.0190076556601 ko04912 GnRH signaling pathway 6/127 122/7206 0.0204482892546 ko04722 Neurotrophin signaling pathway 7/127 160/7206 0.0226317677565 ko04072 Phospholipase D signaling pathway 8/127 197/7206 0.0227504813351 ko00770 Pantothenate and CoA biosynthesis 2/127 14/7206 0.0244180703253 ko04915 Estrogen signaling pathway 6/127 131/7206 0.0278551452999 ko04010 MAPK signaling pathway 11/127 321/7206 0.0286559886235 ko04713 Circadian entrainment 6/127 136/7206 0.0326519787983 ko00983 Drug metabolism - other enzymes 3/127 42/7206 0.0372714053321 ko04916 Melanogenesis 6/127 142/7206 0.0390821225992 ko04626 Plant-pathogen interaction 2/127 18/7206 0.0392219515367 ko04727 GABAergic synapse 5/127 110/7206 0.04441264572 ko04070 Phosphatidylinositol signaling system 5/127 112/7206 0.0473689868865 ko05414 Dilated cardiomyopathy 5/127 112/7206 0.0473689868865 ko04016 MAPK signaling pathway - plant 2/127 20/7206 0.047612223806 ko04215 Apoptosis - multiple species 3/127 47/7206 0.0494411230574