ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 22/219 191/7206 6.06870548566e-08 ko05150 Staphylococcus aureus infection 10/219 36/7206 6.96739206781e-08 ko05164 Influenza A 20/219 167/7206 1.31028930125e-07 ko05152 Tuberculosis 20/219 187/7206 8.37012004697e-07 ko05340 Primary immunodeficiency 8/219 30/7206 2.1048596485e-06 ko05162 Measles 15/219 120/7206 3.01756531403e-06 ko04610 Complement and coagulation cascades 12/219 79/7206 3.89993445108e-06 ko04621 NOD-like receptor signaling pathway 17/219 157/7206 4.87641358514e-06 ko04650 Natural killer cell mediated cytotoxicity 13/219 97/7206 6.44198633369e-06 ko05133 Pertussis 12/219 87/7206 1.09002591916e-05 ko04672 Intestinal immune network for IgA production 8/219 37/7206 1.1553980844e-05 ko05140 Leishmaniasis 11/219 75/7206 1.4065422068e-05 ko05321 Inflammatory bowel disease (IBD) 9/219 56/7206 4.10139197477e-05 ko04620 Toll-like receptor signaling pathway 12/219 100/7206 4.5574483286e-05 ko04380 Osteoclast differentiation 14/219 134/7206 5.11787096978e-05 ko04666 Fc gamma R-mediated phagocytosis 13/219 122/7206 7.75798614007e-05 ko04612 Antigen processing and presentation 10/219 77/7206 0.000101024028327 ko05145 Toxoplasmosis 13/219 126/7206 0.000108331027508 ko05168 Herpes simplex infection 16/219 182/7206 0.000122671851547 ko05323 Rheumatoid arthritis 10/219 89/7206 0.000340784747163 ko04660 T cell receptor signaling pathway 12/219 124/7206 0.000363772903843 ko05144 Malaria 7/219 45/7206 0.000369068859744 ko04630 Jak-STAT signaling pathway 12/219 132/7206 0.000643996831293 ko05161 Hepatitis B 14/219 173/7206 0.000755348054741 ko04933 AGE-RAGE signaling pathway in diabetic complications 12/219 135/7206 0.000787758409476 ko04623 Cytosolic DNA-sensing pathway 6/219 41/7206 0.00135805293921 ko04659 Th17 cell differentiation 10/219 106/7206 0.00136258297085 ko04670 Leukocyte transendothelial migration 12/219 151/7206 0.00208412727989 ko04064 NF-kappa B signaling pathway 9/219 96/7206 0.00245485025438 ko04622 RIG-I-like receptor signaling pathway 7/219 62/7206 0.00258486289741 ko05131 Shigellosis 8/219 82/7206 0.00330285448663 ko04062 Chemokine signaling pathway 14/219 201/7206 0.00499860510922 ko04662 B cell receptor signaling pathway 8/219 88/7206 0.00510131404619 ko04080 Neuroactive ligand-receptor interaction 4/219 423/7206 0.00526807950181 ko05330 Allograft rejection 4/219 24/7206 0.00546651674557 ko05142 Chagas disease (American trypanosomiasis) 10/219 130/7206 0.00606396796565 ko04514 Cell adhesion molecules (CAMs) 10/219 130/7206 0.00606396796565 ko04142 Lysosome 11/219 151/7206 0.00612978928957 ko05020 Prion diseases 5/219 40/7206 0.00685059228498 ko05167 Kaposi's sarcoma-associated herpesvirus infection 13/219 191/7206 0.00786110287889 ko05166 HTLV-I infection 17/219 292/7206 0.00853013042162 ko04658 Th1 and Th2 cell differentiation 8/219 96/7206 0.00856389325072 ko05132 Salmonella infection 8/219 98/7206 0.00965395339059 ko05320 Autoimmune thyroid disease 4/219 29/7206 0.0108558756266 ko04210 Apoptosis 12/219 180/7206 0.0121624105151 ko05212 Pancreatic cancer 7/219 83/7206 0.0127845719468 ko05310 Asthma 3/219 17/7206 0.0137399732866 ko05332 Graft-versus-host disease 3/219 18/7206 0.0161248242787 ko00120 Primary bile acid biosynthesis 3/219 20/7206 0.0215482372324 ko04122 Sulfur relay system 2/219 8/7206 0.0228139523413 ko05016 Huntington's disease 1/219 215/7206 0.0231688766609 ko04217 Necroptosis 11/219 178/7206 0.0233475432599 ko05416 Viral myocarditis 5/219 55/7206 0.0251421844841 ko05160 Hepatitis C 10/219 153/7206 0.0263574426805 ko04664 Fc epsilon RI signaling pathway 6/219 77/7206 0.0291226570655 ko04668 TNF signaling pathway 8/219 120/7206 0.0293640432283 ko05100 Bacterial invasion of epithelial cells 7/219 99/7206 0.0306179066062